Discuss the general function of the microRNA precursor, miR-7.

Expert Solution

Ans . A micro RNA(mi RNA) is a small non-coding RNA molecule ( containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression. miRNAs function via base-pairing with complementary sequences within mRNA molecules.

microRNA precursor miR-7 :-

miR-7 is directly regulated by the transcription factor HoxD10.

miRNAs have regulatory roles through complementarity to mRNA . miR-7 is essential for the maintenance of regulatory stability under conditions of environmental flux. It plays an important role in controlling mRNA expression.

miR-7 acts as an oncomiR in the epithelial cells, where through negative regulation of KLF4-dependent signalling pathways, miR-7 promotes cellular transformation and tumor growth. Activation of developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.

gladiator answered 2 years ago

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