Question

How do arenes bind to metal center

Answer 1

Arene and metal interactions are a type of non-covalent interaction that involves π system which can interact with a metal (cationic or neutral), an anion, another molecule and even another π system Just like in an electrostatic interaction just like negative charge interacts with a positive charge. Non-covalent interactions involving π systems are important to biological events such as protein-ligand recognitionArene and metal interactions are a type of non-covalent interaction that involves π system which can interact with a metal (cationic or neutral), an anion, another molecule and even another π system Just like in an electrostatic interaction just like negative charge interacts with a positive charge. Non-covalent interactions involving π systems are important to biological events such as protein-ligand recognition

Arene sandwich complexes can be prepared by two common methods in which a metal is squished between two arenes. Treatment of metal halide with a Lewis acid and mild reductant replaces the halogen atoms with arene ligands. The scope of this method is fairly broad metal-wise and the example is given below.

Syntheses of metal arene carbonyl complexes take advantage of the fact that arenes are strongly binding, “chelating” ligands. IR studies have shown that a single benzene ligand is a stronger electron donor than three CO ligands—C–O stretching frequencies are lower in metal arene carbonyls than homoleptic metal carbonyls. Since the process is entropically driven, a little heat can get the job done

arene pi bond interaction with metal is playing pivoltal role in the foloowing coupling reaction which are industrially used.The examples are given below

1) Suzuki Coupling

2) Sonogoshir coupling

3)Stille Coupling

4) Heck Coupling and so on..