What is the point of omega oxidation? I understand the mechanism, but I am reading that...

What is the point of omega oxidation? I understand the mechanism, but I am reading that it is an alternative when Beta oxidation is not working properly. This doesnt make sense to me because onega oxidation just feeds things into the beta oxidation pathway, so if the beta isnt working how would the omega work?

Expert Solution

Although it's true that omega oxidation process is normally a minor catabolic pathway for medium-chain fatty acids (10-12 carbon atoms), and becomes more important when β oxidation is defective. But other than that it has some other significances like:

Many studies have demonstrated that the ω-oxidation serves to provide succinyl-CoA for the citric acid cycle and for gluconeogenesis under conditions of starvation and diabetes.

Also ω- and (ω-1)-oxidation of fatty acids play crucial roles in the production of insect pheromones of honeybees and in the formation of biopolyesters of higher plants.

It is observed that ω- and (ω-1)-oxidation of fatty acids are related to energy metabolism in some laboratory animals such as musk shrews and Mongolian gerbils.

Also there is biological significance of ω-oxidation of prostaglandins and leukotrienes.

Hope this helps

Ps- An upvote would be highly appreciated

gladiator answered 2 years ago

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