A protein that functions as a corepressor for gene expression can modify chromatin structure as well...

A protein that functions as a corepressor for gene expression can modify chromatin structure as well as DNA structure. Describe the modifications that this protein performs, and explain how this affects chromatin structure and transcriptional activity. (3 pts)

Expert Solution

Answer:

A repressor protein is a molecule which inhibits the expression of gene either one or many, by binding to the corresponding DNA/RNA.
The function of repressor is to block the RNA polymerase attachment at the promoter site, thus inhibits transcription.
Whereas, corepressor is a small molecule which could be protein, doesnt bind to DNA directly.
Instead, it associates with repressor molecule or transcription factors and thus helps in down-regulating gene expression.
In the presence of coactivators, transcription factors will upregulate gene expression.
Both coactivators and corepressors compete for the same binding sites on repressor molecules, therefore results in the a possibility of DNA transcription regulation.
Another mechanism of reprssion can be done through signalling of histone deacetylases. T
enzymes removes acetyl groups from lysine, thus creating a postive charge on histones.
When histone protein were more positiveley charged a strong electrostatic interaction between them and DNA will result in tight packing.
Due to their strong attraction, transcriptional factors will have not access to DNA and so transcriptional activity will also be regulated.

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