Question

Material Safety Data Sheets or Safety Data Sheets (MSDS/SDS) – The Worker’s Right to Know Law grants employees the right to know the hazards of all chemicals in their work place. These hazards can be found in the MSDS or SDS forms that employers are required to maintain for all hazardous chemicals used at the facility. MSDS and SDS are very similar, but the latter is an updated version designed to increase consistency.

MSDS/SDS: (10pts) (need word file) and post the sources where to find that information

Sources of MSDS/SDS: (1pt)

1, What is the definition of LD₅₀? Identify the source of this definition. (1pt)

2. Assuming that these compounds are similarly toxic to humans, how much of each compound would be required to reach the LD₅₀ for a 150 pound human? Show your calculations. (4pts)

3. Which of the two compounds is more toxic? How can you tell? (2pts)

4. What are the acute effects of exposure for each compound? (1pt)

5. What does the MSDS/SDS recommend be done if each compound is ingested? (1pt)

Rubric:

Sources of documents and definitions cited (URL’s)

Responses in your own words and in complete sentences

Short answer responses supported with evidence, of appropriate length, and grammatically adequate

Organized calculations with units and correct sig figs

Answer 1

1)

LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.

Toxicologists can use many kinds of animals but most often testing is done with rats and mice. It is usually expressed as the amount of chemical administered (e.g., milligrams) per 100 grams (for smaller animals) or per kilogram (for bigger test subjects) of the body weight of the test animal. The LD50 can be found for any route of entry or administration but dermal (applied to the skin) and oral (given by mouth) administration methods are the most common.

2)LD50 oF Zinc Oxide = mg chem/kg body

LD50 oF Zinc Oxide= 7950mg/kg150pounds = 150lbs(1kg/2.2lbs)=68.2kgmg

chem = (LD50 oF Zinc Oxide) X (kg body)

mg chem=(7950mg/kg)X(68.2kg)=542000mg

LD50 oF Glucose= mg chem/kg body

mgchem = (LD50 oF Glucose) X (kg body)

mg chem = 30g/kg= 30g/kg(1000mg/1g)=30000mg

LD50 of Glucose= (30000mg/kg )X(68.2kg)=2046000mg

3)Glucose is more toxic than Zinc Oxide because Zinc Oxide itself and its products of degradation are not toxic.

4)Zinc Oxide causes mild skin irritaton, eyes irritaton and conjunctvits.-Glucose may cause the poisonous and may alter genetic material andcause eyes, skin and upper respiratory tracat irritation.

5)No more than430 mg/m3 for Zinc Oxide.Expected to be a low ingesTon hazard for Glucose.