Question

In: Anatomy and Physiology

Is the following the correct order of steps leading to muscle contraction? (Yes or No) If...

Is the following the correct order of steps leading to muscle contraction? (Yes or No)

If you think the order is incorrect, then what would be the correct order?

a. secretion of acetylcholine by the motor neuron

b. attachment of acetylcholine to receptors on the motor end plate of the sarcolemma

c. opening of sodium channels in the sarcolemma

d. depolarization of the sarcolemma

e. action potential reaching the sarcoplasmic reticulum

f.   release of calcium ions by the sarcoplasmic reticulum

g. binding of calcium ions to troponin on the thin filament

h. binding of myosin to actin (formation of cross bridges)

i.   power stroke

Solutions

Expert Solution

Answer

Yes, the steps mentioned above are in the correct order that leads to muscle contraction.

  • A somatic motor neuron innervates skeletal muscle fiber.
  • It releases a neurotransmitter called acetylcholine from its synaptic vesicles through exocytosis.
  • Acetylcholine binds to its receptors on the sarcolemma. This binding causes opening of voltage gated sodium channels that allows soidum ions to enter the muscle fiber.
  • Influx of sodium ions depolarizes the sarcolemma that eventuallt leads to generation of action potential.
  • T-tubules carry action potention to the interior of muscle fiber. As the action potentialr eaches sarcoplamic reticulum, it releases calcium ions into the sarcoplasm.
  • Calcium binds to a protein called troponin. This events brings a conformational change in troponin shapes that shifts tropomyosin away from the myosin binding sites on actin filament.
  • As the active binding sites are exposed, myosin binds to the actin forming a cross-bridge.
  • This leads to a power stroke where myosin pulls actin towards the center to sarcomere.

Sydney Mullin answered 8 months ago
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