Question

HbR is reported to have P50=14torr and a Hillcoefficient=1.2. Calculate ΔYO2 for a climber with HbR assuming that, at 14,000 ft (∼4300m), PO2=50mmHg in lungs and PO2=10mmHg in muscle capillaries.

Answer 1

Step1:

**Please refer attached hand written images which is clearly calculated

HbR refers to the hemoglobin in relaxed state that is; it is bound with a minimum of one oxygen molecule.

Fractional saturation of oxygen is given by the below formula where, YO2 is the fractional saturation of oxygen, n is the Hill coefficient, P50 is the partial pressure of oxygen at 50% and PO2 is the given partial pressure of oxygen.

Formulae for this is attched with hand written image.

Step2:

Calculate the YO2 when Hill co-efficient is 1.2, P50 is 14 torr and PO2 is 50 mm of Hg in lungs at 14,000 ft in the given equation.

by using equation the answer will be ΔYO2 =0.04

**Please refer attached hand written images which is clearly calculated.

Step3:

Calculate the YO2 when Hill co-efficient is 1.2, P50 is 14 torr and PO2 is 10 mm of Hg in lungs at 14,000 ft in the given equation.

by using equation the answer will be ΔYO2 =0.04

**Please refer attached hand written images which is clearly calculated.

Continued in the next images as below