Friedel-Crafts alkylation of anisole (PhOCH3) with tert-butyl chloride [(CH3)3CCl] and AlCl3 gives mostly the para-substituted product....

Friedel-Crafts alkylation of anisole (PhOCH3) with tert-butyl chloride [(CH3)3CCl] and AlCl3 gives mostly the para-substituted product. Explain this outcome by showing the complete step wise mechanisms for para and meta positions using the curved arrow notation. The mechanisms must include the formation of the electrophile, attack of the electrophile at the meta and para positions, as well as all stabilizing resonances of the arenium ions that are formed and their relative stability, and the final substitution products.

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queen_honey_blossom answered 2 years ago

In friedel-crafts alkylation of benzene with an alkyl halide and AlCl3: 1. In terms of intermediate...

In friedel-crafts alkylation of benzene with an alkyl halide and AlCl3: 1. In terms of intermediate and product stabilities explain why the ortho and para isomers would be favored under kinetic conditions and why the meta isomer would be favored under thermodyanmic conditions? 2. What function does the nitromethane serve in the kinetic reaction? 3. What reactants would you employ for the preparation of the following compounds by reactions of the Friedel-crafts type? - a. diphenylmethane - b. 4-bromophenyl phenyl...

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Friedel-Crafts alkylation of anisole (PhOCH3) with tert-butyl chloride [(CH3)3CCl] and AlCl3 gives mostly the para-substituted product....

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In friedel-crafts alkylation of benzene with an alkyl halide and AlCl3: 1. In terms of intermediate...