Question

List and briefly describe the "varieties " of ion channel gating regulation

Answer 1

1. Voltage gated ion channels: Voltage-dependent ion channels are membrane proteins that conduct ions at high voltage regulated rates across the membrane. They play a key role in the generation and spread of nerve impulses and cell homeostasis. The voltage sensor is a protein-bearing region of the charged amino acids that moves on changes in the electrical membrane field.The motion of the sensor initiates a conformational change in the gate of the conductive pathway, thus controlling the flow of ions. Recent developments in molecular biology, spectroscopy, and structural techniques outline the main features and potential structural changes that account for the function of voltage-dependent channels.

2. Ligand gated ion channel: Ligand-gated ion channels are proteins of the membrane that are the essential signaling molecules in the neurons. Such molecules are found in plasmalemma and intracellular organelles and can be gated by intracellular and extracellular ligands.

3. Other getting :

This heading includes the activation and inactivation of ion channels by second messengers. Examples are:
1. Photon light-closed channels are activated and deactivated in response to light and are synthesized in the laboratory. Many light-sensitive channels are found in nature, such as canalrhodopsin. Photoreceptor proteins are also light sensitive and G proteins are also gated.

2 . Cyclic nucleotide-closed channels are activated by hyperpolarization These are permeable to monovalent and divalent cations, such as K+, Na+ and Ca2+.
3. Temperature-closed channels are part of the transient ion channel superfamily potential receptor and are activated by hot or cold temperatures.