Question

In: Biology

The following couples plan to marry and want to know the chance of having a child...

The following couples plan to marry and want to know the chance of having a child with the following diseases. You are a genetic counselor who needs to answer their questions. Write out the genotypes of the crosses and perform a Punnett square to determine the probability of the child inheriting the disease.

            a. an affected father and carrier mother for color blindness (X-linked recessive)

            b. an unaffected father and a carrier mother for hemophilia (X-linked recessive)

            c. an unaffected father and an unaffected mother for color blindness

            d. an affected father and an unaffected mother for color blindness

Solutions

Expert Solution

a) Genotype of affected father for color blindness  - XcY.

Genotype of carrier mother for color blindness - X+Xc.

Cross between them XcY X   X+Xc.

Gametes formed    Xc and Y X+ and Xc

Next generation   

Male/Female X+ Xc
Xc X+Xc(unaffected carrier female) XcXc(colorblind female)
Y X+Y(unaffected male) XcY(colorblind male)

The probability of the child inheriting the disease - 1/2 .

b)  an unaffected father and a carrier mother for hemophilia.

Genotype of unaffected father for hemophilia - XY.

Genotype of carrier mother for hemophilia - XhX.

Cross between them XY X XhX

Gametes formed X and Y Xh and X.

Next generation

Male/Female X Y
Xh XhX(unaffected carrier female) XhY(affected male)
X XX(noraml female) XY(unaffected or normal male)

The probability of the child inheriting this disease - 1/4.

c) an unaffected father and an unaffected mother for color blindness.

Genotype of unaffected father for color blindness  - XY.

Genotype of unaffected mother for color blindness - XX.

All are unaffected, then the probability of the child inheriting this disease - zero 0%.

d) an affected father and an unaffected mother for color blindness.

Genotype of affected father for color blindness  - XcY.

Genotype of unaffected mother for color blindness - XX.

Cross between them XcY X XX

Gametes formed   Xc and Y X and X.

Next generation

Male/Female    Xc Y
X    XcX(unaffected carrier female) XY(unaffected male)
X    XcX(unaffected carrier female) XY(unaffected male)

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