What steps are needed to make UMP into dTMP? Write out each step, using standard abbreviations...

What steps are needed to make UMP into dTMP? Write out each step, using standard abbreviations for the nucleotides, and including co-substrates that make sense or are specifically needed (for each step).

Expert Solution

Process of conversion of UMP to dTMP takes place in the following steps:

1. Formation of UDP from UMP through the enzyme nucleoside monophosphate kinase by the conversion of ATP to ADP.

UMP+ATP --> UDP + ADP.

2. The conversion of UDP to dUDP by the enzyme ribonucleotide reductase class1. This reduces the carbon at C2 position of the ribose sugar hence converting it to deoxyribose sugar.

UDP+NADPH--->dUDP+NADP+

3. Conversion of the dUDP to dUTP which is catalysed by nucleoside diphosphate kinase coupled to the subsequent conversion of ATP to ADP.

dUDP+ATP--->dUTP + ADP

4. The conversion of dUTP to dUMP by the enzyme dUTP pyrophosphatase.

dUTP +H2O ---> dUMP + PPi

5. The conversion of dUMP to dTMP catalysed by the thymidylaste synthase with N5,N10- methylenetetrahydrofolate as the methyl donor.

dUMP + NA,N10 - methylenetetrahydrofolate ---> dTMP + dihydrofolate.

In this way UMP is converted to dTMP.

If you have any query kindly comment before giving thumbs up. Thank you.

gladiator answered 1 year ago

make a list of all the steps needed to calculate a confidence interval using a z-distribution.

What are the initial steps in the accounting cycle and what happens in each step ?...

What are the initial steps in the accounting cycle and what happens in each step ? Explain in detail.

Code needed in C++ (nOT IN STEP BY STEP EITHER) Write a recursive function that...

Code needed in C++ (nOT IN STEP BY STEP EITHER) Write a recursive function that computes the sum of the digits in an integer. Use the following function header: int sumDigits(int n) For example, sumDigits(234) returns 2 + 3 + 4 = 9. Write a test program that prompts the user to enter an integer and displays its sum.

Please write a multiple step income statement using the following accounts as needed. The tax rate...

Please write a multiple step income statement using the following accounts as needed. The tax rate is 30%. Common stock 1,000,000 Retained Earnings 3,200,000 Dividends 500,000 Interest Income 250,000 Interest Expense 100,000 Dividend Income 50,000 Gain on Disposal of Plant Assets 100,500 Unrealizezd Gain on Trading Securities 65,000 Unrealized Gain on Available for sale securities 10,000 Cost of Goods Sold 286,000 Selling Expenses 140,000 Sales Salaries Expenses 34,000 Depreciation Expense 100,000 Amortization Expense 25,000 Loss on Assset Impairment ...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish null and alternate hypotheses- State the null and alternative hypothesis (as a sentence and formula). Step 2: Calculate the degrees of freedom Step 3: Calculate t critical using critical t – table Step 4: Calculate the Sum of Square deviation (SSD) Step 5: Calculate t obtained Step 6: Specify the critical value and the obtained value on a t-distribution curve Step 7: Decision and...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish null and alternate hypotheses State the null and alternative hypothesis (as a sentence and formula). Step 2: Calculate the degrees of freedom Step 3: Calculate t critical using critical t – table Step 4: Calculate the Sum of Square deviation (SSD) Step 5: Calculate t obtained Step 6: Specify the critical value and the obtained value on a t-distribution curve Step 7: Decision and...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish null and alternate hypotheses- State the null and alternative hypothesis (as a sentence and formula). Step 2: Calculate the degrees of freedom Step 3: Calculate t critical using critical t – table Step 4: Calculate the Sum of Square deviation (SSD) Step 5: Calculate t obtained Step 6: Specify the critical value and the obtained value on a t-distribution curve Step 7: Decision and...

what are the six steps of a statistical inverstgation? describe each step in context of the...

what are the six steps of a statistical inverstgation? describe each step in context of the organ donor example.( in your own words)

draw out step by step!! and have mini-explanations under each step explaining what is happnening SHOW...

draw out step by step!! and have mini-explanations under each step explaining what is happnening SHOW THE peptide bond hydrolysis mechanism of how: a)cysteine proteases work b) aspartyl proteases work c) metallo proteases work d)how does eptide hydrolysis by trypsin, elastase work with proteases?

Write the balanced equation for the hydration of CuSO4. Indicate the physical states using the abbreviations...

Write the balanced equation for the hydration of CuSO4. Indicate the physical states using the abbreviations (s), (l), or (g) for solid, liquid, or gas, respectively. Use (aq) to indicate the aqueous phase. Indicate appropriate charges on negative and positive ions if they are formed.

Question

What steps are needed to make UMP into dTMP? Write out each step, using standard abbreviations...

Solutions

Expert Solution

Related Solutions

make a list of all the steps needed to calculate a confidence interval using a z-distribution.

What are the initial steps in the accounting cycle and what happens in each step ?...

Code needed in C++ (nOT IN STEP BY STEP EITHER) Write a recursive function that...

Please write a multiple step income statement using the following accounts as needed. The tax rate...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish...

In answering the question(s), make sure to write down the following 7 steps. Step 1: Establish...

what are the six steps of a statistical inverstgation? describe each step in context of the...

draw out step by step!! and have mini-explanations under each step explaining what is happnening SHOW...

Write the balanced equation for the hydration of CuSO4. Indicate the physical states using the abbreviations...