What steps are needed to make UMP into dTMP? Write out each step, using standard abbreviations...

What steps are needed to make UMP into dTMP? Write out each step, using standard abbreviations for the nucleotides, and including co-substrates that make sense or are specifically needed (for each step).

Expert Solution

Process of conversion of UMP to dTMP takes place in the following steps:

1. Formation of UDP from UMP through the enzyme nucleoside monophosphate kinase by the conversion of ATP to ADP.

UMP+ATP --> UDP + ADP.

2. The conversion of UDP to dUDP by the enzyme ribonucleotide reductase class1. This reduces the carbon at C2 position of the ribose sugar hence converting it to deoxyribose sugar.

UDP+NADPH--->dUDP+NADP+

3. Conversion of the dUDP to dUTP which is catalysed by nucleoside diphosphate kinase coupled to the subsequent conversion of ATP to ADP.

dUDP+ATP--->dUTP + ADP

4. The conversion of dUTP to dUMP by the enzyme dUTP pyrophosphatase.

dUTP +H2O ---> dUMP + PPi

5. The conversion of dUMP to dTMP catalysed by the thymidylaste synthase with N5,N10- methylenetetrahydrofolate as the methyl donor.

dUMP + NA,N10 - methylenetetrahydrofolate ---> dTMP + dihydrofolate.

In this way UMP is converted to dTMP.

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gladiator answered 1 year ago

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What steps are needed to make UMP into dTMP? Write out each step, using standard abbreviations...

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