5. If 1/1000 individuals with your genetic background are carriers for a certain autosomal, recessive disease...

5. If 1/1000 individuals with your genetic background are carriers for a certain autosomal, recessive disease allele, what is the chance that both you and your spouse will be carriers?

6. (Related to 5) What is the chance that you will both be carriers and have an affected child?

7. (Related to 5 and 6) If you are a carrier for this disease allele and your spouse’s status is unknown, what is you chance of having a child with the disease?

Expert Solution

Answer:

5. If 1/1000 individuals with your genetic background are carriers for a certain autosomal, recessive disease allele, what is the chance that both you and your spouse will be carriers?

Chance that husband is carrier = 1/1000
Chance that wife is carrier = 1/1000
Since both of these are independent events, therefore, chance that both husband and wife will be carriers = 1/1000 * 1/1000 = 10^-6

6. (Related to 5) What is the chance that you will both be carriers and have an affected child?

Chance that both are carriers = 10^-6
Chance that a affected child is born to carrier parents = 0.25 (1 in 4)
Chance that both will be carriers and have an affected child = 0.25*10.^-6 = 2.5*10^-7

7. (Related to 5 and 6) If you are a carrier for this disease allele and your spouse’s status is unknown, what is you chance of having a child with the disease?

This will be a combination of two cases:

a) Both husband and wife are carrier

Chance of having a child with the disease (1 in 4) = 0.25*10.^-6 = 2.5*10^-7

b) Husband is carrier and wife is affected (2 in 4) = 0.50*10.^-6 = 5.0*10^-7

c) Husband is carrier and wife is not affected = 0

Probability = 2.5*10^-7 + 5.0*10^-7 = 7.5 *10^-7

gladiator answered 2 years ago

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