For each of the following items indicate "A" if it is a typical change occurring during...

For each of the following items indicate "A" if it is a typical change occurring during apoptosis or "N" if it is a typical change occurring during necrosis.

A N  Release of small cell fragments
A N  Involved in developmental regulation
A N  Release of soluble protein into extracellular
A N  Cell swelling
A N  Triggers inflammation

Expert Solution

A - Release of small cell fragments (1)

A - Involved in developmental process (2)

N - Release of soluble protein into extracellular (3)

N - Cell swelling (4)

N - Triggers inflammation (5)

Contrasting features of Apoptosis Necrosis
Feature	Apoptosis	Necrosis
Definition	Programme and coordinated cell death	Cell death along with degradation of tissue by hydrolytic enzyme
Causativeagent	Physiologically and pathological process (Developemental process) (2)	Hypoxia, toxins
Morphology	No inflammation seen	Inflammatory reaction always present (5)
	Death of single cell	Death of many adjacent cells
	Cell shrinkage	Cell swelling (4)
	Cytoplasmic blebs on membrane	Membrane disruption
	Apoptotic bodies form from cell fragmentation (1)	Damaged organelles
	Chromatin condensation	Nuclear disruption
	Phagocytosis of apoptotic bodies by macrophages	Phagocytosis of cell debris by macrophages
Molecular changes	Lysosomes and other organelles intact	Lysosomal breakdown with liberation of hydrolytic enzyme (3)
	Triggered by intrinsic pathway, extrinsic pathway and caspases	cell death by ATP depletion, free radical injury

The points of the question have been mentioned in the chart to compare between two process.

gladiator answered 2 years ago

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