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In: Biology

What malfunctioning mechanisms could be contributing to the development of anencephaly? Anencephaly is likely caused by...

  1. What malfunctioning mechanisms could be contributing to the development of anencephaly?
  1. Anencephaly is likely caused by a problem with which of the following? a. Primary neurulation b. Secondary neurulation c. Junctional neurulation

  1. Develop a model of anencephaly based upon a problem with alterations in cell polarity.

  1. Develop a model of anencephaly based upon a problem with morphogen signaling.

  1. Develop a model of anencephaly based upon a problem with cell to cell interactions.

Solutions

Expert Solution

Absence of brain and vskull vault due to neural tissue degeneration following failed cranial neural tube closure during SECONDARY NEURULATION reults in ANENCEPHALY.

MUTATIONS in planar cell polarity genes cause variety of neural tube defects in mice and humans.SCRIB is a PCP associated gene MICE that arer homozygous for Scrib p.i285K and circletail(crc) mutationspresent with most severe form of NTD NAMED CRANIORACHISCHISIS. MUTATION in SCRIB WERE ASSOCIATED WITH CRANIORACHISCHISIS IN HUMANS TOO.rare deleterios mutations of SCRIB may contribute multifactorial risk for human spina bifida.

A morphogen gradient of Wnt/beta catenin signalling regulates and caused anencephaly and secondary tail formation.

IN THIRD WEEK OF PREGNANCY CALLED GASTRULATION special;ized cells on dorsal side of embryo begun changing shape and form neural tube but when neural tube doesnt close completelt NTD develops.

M

gladiator answered 2 months ago
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