1) If you make a conditional knockout of FGF8 in the somitic and lateral plate mesoderm...

1) If you make a conditional knockout of FGF8 in the somitic and lateral plate mesoderm of the mouse at the onset of limb bud formation (AFTER somites have already formed), meaning that FGF8 is only depleted in these tissues, describe the limb phenotypes you expect to observe. Explain your answer.

2) What if you did the same experiment but this time conditionally removed FGF10 from the somatic and lateral plate mesoderm of the mouse? Explain your answer

3) If you make a conditional knockout of Shh in the somitic and lateral plate mesoderm of the mouse at the onset of bud formation, describe the limb phenotypes you expect to observe. Explain your answer.

Expert Solution

All the answers with explanation are provided in the pictures above.

gladiator answered 2 years ago

If I conditionally knockout FGF8 in the somatic and lateral plate mesoderm of a mouse during...

If I conditionally knockout FGF8 in the somatic and lateral plate mesoderm of a mouse during the onset of limb bud formation what would the resulting phenotype look like? What about if I knocked out Shh instead?

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