In: Biology
1) Draw and explain why the conformation freedom of peptides is limited.
2) Discuss the roles of hemoglobin and myoglobin in transporting oxygen and carbon dioxide
1) The conformation is limited to rotations on the bonds which
leads to alpha carbon atoms and due to the rigid nature of peptide
bond its restricted. The c-N bond length of peptide is 10% shorter
than fond in the usual amine bonds. Because the peptide bond has a
double bond character of about 40% due to its resonance. So the
peptide bonds are planar. Their rigidity will reduce its freedom of
polypeptide during its folding. The steric hinderance shown in the
diagram between the functional groups attached to alpha atoms will
be large in cis configuration. t2) Oxygen cobines with Hb to
form oxyhaemoglobin and in the lungs where the partial pressure of
oxygen is high, the reaction will be proceeding on the right to
form oxyhaemoglobin and in tissues where the partial pressure of
oxygen is low, the reaction will get reversed and Oxyhaemoglobin
will release O2 forming deoxyhaemoglobin.
Role of Myoglobin in O2 and
CO2 transport- Myoglobin is an iron containing protein which
recieves O2 from RBC's and transports it to mitochondria where O2
gets used for cellular respiration and produces ATP. And therefore
provide O2 to working muscles. They have one heme prosthetic group.
It allows organisms to hold their breath for a long period of time.
It has an increased affinity for O2 than Hb. Myoglobin does not
bind to CO2.