Question

Discuss the modern drug discovery process and how it has facilitated the throughput of drug discovery.

this question is biochemistry question

Answer 1

Discuss the modern drug discovery process and how it has facilitated the throughput of drug discovery.

The modern process of drug discovery is as follows:

• Collection of compounds, through the processes of primary assays which would be of high throughput assays
• This would be followed by secondary assays in which there would be secondary assays where counter screening methods along with bioavailability, toxicity assays as well as metabolic screening.
• Clinical candidate would be identified through secondary assays
• In the indirect method, there would be synthesis of lead compounds and SAR, in which there would be structural characterisation of the protein ligand complexes would be identified
• This would be followed by designing of the compound
• The end process would be chemical synthesis.

High throughout screening is the method in which there would be experimentation through the discovery of drugs. As a result of high throughout screening, there would be conduction of the genetic as well as pharmacological tests. In this process, a person would be able to identify the active compounds as well as antibodies, along with genes that would be modulating the biochemical pathways. This allows for the starting point of the drug designing.