When the receptor binds the trimeric G-proteins, it acts as a
GEF for the alpha (α) subunit, forcing the alpha subunit to
exchange its GDP for a GTP. GTP-binding by the α subunit causes it
to dissociate from the Beta-Gamma subunits, leading to activation
of both. If the receptor can’t bind the trimeric G-protein, the α
subunit will remain in the GDP. In another scenario, it can be in
an inactive state, and will remain bound to the Beta-Gamma
subunits....