Question

In: Biology

Chapter 9: The discussion topic for this week is very interesting, as it is likely that...

Chapter 9: The discussion topic for this week is very interesting, as it is likely that everyone at least knows someone who has some type of genetic disorder or has heard about a disorder that they wanted to understand more fully. You should look into a specific disorder and provide more information about it from any angle you like. Please be sure to include some information that pertains to the chapter (like the inheritance pattern--that is, whether it is autosomal dominant or recessive or sex-linked or whatever). ***I absolutely need in text citations and the ending reference citations...*****

You should look into a specific disorder and provide more information about it from any angle you like.

Please be sure to include some information that pertains to the chapter (like the inheritance pattern---this is the question

Solutions

Expert Solution

Modes of Inheritance

  • Inheritance patterns help to predict the recurrence risk for relatives.
  • In general, inheritance patterns for single gene disorders are classified based on whether they are autosomal or X-linked and whether they have a dominant or recessive pattern of inheritance. These disorders are called Mendelian disorders, after the geneticist Gregor Mendel.

Autosomal Dominant Inheritance

  • In autosomal dominant inheritance, only one copy of a disease allele is necessary for an individual to be susceptible to expressing the phenotype.
  • With each pregnancy, there is a one in two (50%) chance the offspring will inherit the disease allele.
  • Unless a new mutation has occurred, all affected individuals will have at least one parent who carries the disease allele.
  • Autosomal dominant inheritance is often called vertical inheritance because of the transmission from parent to offspring.
  • Across a population, the proportion of affected males should be equal to the proportion of affected females.
  • Male-to-male transmission can be observed.
  • Examples of diseases with autosomal dominant inheritance include myotonic muscular dystrophy and Huntington disease.

Autosomal Recessive Inheritance

  • In autosomal recessive inheritance, two copies of a disease allele are required for an individual to be susceptible to expressing the phenotype.
  • Typically, the parents of an affected individual are not affected but are gene carriers.
  • As with autosomal dominant inheritance, the proportion of affected males should be equal to the proportion of affected females in a given population.
  • Examples of diseases with autosomal recessive inheritance include sickle cell anemia and cystic fibrosis.

X-Linked Dominant Inheritance

  • As in autosomal dominant inheritance, only one copy of a disease allele on the X chromosome is required for an individual to be susceptible to an X-linked dominant disease.
  • Both males and females can be affected, although males may be more severely affected because they only carry one copy of genes found on the X chromosome. Some X-linked dominant disorders are lethal in males.
  • When a female is affected, each pregnancy will have a one in two (50%) chance for the offspring to inherit the disease allele. When a male is affected, all his daughters will be affected, but none of his sons will be affected.

X-Linked Recessive Inheritance

  • As in autosomal recessive inheritance, two copies of a disease allele on the X chromosome are required for an individual with two X chromosomes (a female) to be affected with an X-linked recessive disease.
  • Since males are hemizygous for X-linked genes (they have only one X chromosome), any male with one copy of an X-linked recessive disease allele is affected.
  • Females are usually carriers because they only have one copy of the disease allele. Affected males are related through carrier females.
  • For a carrier female, with each pregnancy there is a one in two (50%) chance her sons will inherit the disease allele and a one in two (50%) chance her daughters will be carriers.
  • Women are affected when they have two copies of the disease allele. All of their sons will be affected, and all of their daughters will be unaffected carriers.
  • Examples of diseases with X-linked recessive inheritance include Duchenne muscular dystrophy, hemophilia A and hypohidrotic or anhidrotic ectodermal dysplasi

Related Solutions

Chapter 9: The discussion topic for this week is very interesting, as it is likely that...
Chapter 9: The discussion topic for this week is very interesting, as it is likely that everyone at least knows someone who has some type of genetic disorder or has heard about a disorder that they wanted to understand more fully. You should look into a specific disorder and provide more information about it from any angle you like. Please be sure to include some information that pertains to the chapter (like the inheritance pattern--that is, whether it is autosomal...
My opinion about topic, group and presentation My opinion about topic : This subject very interesting...
My opinion about topic, group and presentation My opinion about topic : This subject very interesting and useful for me. I have been wanting to study this field for a long time but due to I was busy at university and so on, I could not. When I saw this subject on the table, I was surprised and chose to read and make report for it. Such studies, which paly an important role in my life, are very important for...
Economic growth is a very interesting and important topic. The question is, what is its unit...
Economic growth is a very interesting and important topic. The question is, what is its unit of measurement? What is the difference between economic growth and human development? Please compare and contrast these two concepts. Any thoughts?
This week's discussion will be focused on a topic that is very relevant to today's health...
This week's discussion will be focused on a topic that is very relevant to today's health care environment. We will be discussing the additional health care costs that needed to be budgeted for as a result of Operation Iraqi Freedom (ended 8/10) and Operation New Dawn (ended Dec 2011).
The end of the chapter talks about DNA repair, and the discussion for this topic will...
The end of the chapter talks about DNA repair, and the discussion for this topic will follow up on this idea further. You should do further research on some aspect of DNA repair. For example: how it works the different types why it's important how it can go wrong what results when it goes wrong its importance to cancer.. Do not use other solutions. I need originality responses as well as IN TEXT CITATIONS AND A WORKS CITED REFERENCE. Please...
Choose a discussion topic related to a current marketing event at the beginning of the week...
Choose a discussion topic related to a current marketing event at the beginning of the week of September 27 - October 5. Throughout the week, gather data points related to the marketing event that will determine how successful it was. Share what you learn, including measurable data and what you can infer from it.
a) In Chapter 9 (Week 9 Tutorial) we discussed the integration of the Human Resource Management...
a) In Chapter 9 (Week 9 Tutorial) we discussed the integration of the Human Resource Management and Payroll databases. In particular, we discussed different benefits of this integration in the Week 9 Tutorials. Some companies believe in the integration of HRM and Payroll systems. However, many firms do not agree with this integration. These companies maintain separate HRM information systems and Payroll. Required: Discuss both arguments. For this discussion, think in terms of (1) difference in employee background, and (2)...
Retention of Health Information The topic of discussion this week is retention of health information. Pick...
Retention of Health Information The topic of discussion this week is retention of health information. Pick a state, not necessarily the one you live in now, and use the Internet to research the retention requirements for the state you picked. Write a brief analysis of the retention requirements making sure to include health records, radiology films, death records, and other health record types and formats (i.e. electronic). How do you feel about the requirements? Too restrictive? Not restrictive enough?
This week's discussion board will focus on cancer, a topic very near and dear to my...
This week's discussion board will focus on cancer, a topic very near and dear to my heart, as I lost my first husband in his early 30's over 10 years ago to stage IV brain cancer, so I not only have a lot of experience professionally but also personally in this space. We all know or have known someone touched by the deadly condition. It's a very devastating disease that affects millions of lives per year. Still, we don't have...
Why are accounting periods an interesting topic?
Why are accounting periods an interesting topic?
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT