Can anyone considerably dumb down what this abstract is telling me? I feel like reading this is like reading Latin to me. Can someone help me break down what is being said. Thank you so much.

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)

Numerous studies indicate that Sirtuin 1 (SIRT1), a mammalian nicotinamide adenine dinucleotide (NAD+ )-dependent histone deacetylase (HDAC), plays a crucial role in p53-mediated stress responses by deacetylating p53. Nevertheless, the acetylation levels of p53 are dramatically increased upon DNA damage, and it is not well understood how the SIRT1–p53 interaction is regulated during the stress responses. Here, we identified Set7/9 as a unique regulator of SIRT1. SIRT1 interacts with Set7/9 both in vitro and in vivo. In response to DNA damage in human cells, the interaction between Set7/9 and SIRT1 is significantly enhanced and coincident with an increase in p53 acetylation levels. Importantly, the interaction of SIRT1 and p53 is strongly suppressed in the presence of Set7/9. Consequently, SIRT1-mediated deacetylation of p53 is abrogated by Set7/9, and p53-mediated transactivation is increased during the DNA damage response. Of note, whereas SIRT1 can be methylated at multiple sites within its N terminus by Set7/9, a methylation-defective mutant of SIRT1 still retains its ability to inhibit p53 activity. Taken together, our results reveal that Set7/9 is a critical regulator of the SIRT1-p53 interaction and suggest that Set7/9 can modulate p53 function indirectly in addition to acting through a methylation-dependent mechanism.

p21waf1/cip1 | posttranslational modifications | tumor suppression

I think because there are so many names and players, and being unfamiliar with the terms, it's hard for me to understand.

Any help would be greatly appreciated. Thank you. I will gladly give a good rating.

This is for a research paper

for each of the below topics answer the 5 questions  

1. For each topic do you anticipate using an experimental or a non-experimental approach in your research? Explain the basis for your choice.
2. for each topic state a research hypothesis, purpose, or question for the research you are planning.
3. for each topic Name the major variables you will be studying. Define each variable
4. for each topic are you  conducting “qualitative” or “quantitative” research? Explain the basis for your choice
5. for each topic do you anticipate that the study you are planning will involve human participants? Will you be obtaining informed consent?

Please type and no plagiarism please

Topic ż1 Impact of the increasing trend of online shopping on traditional shopping: the Increased trend of online shopping has led to fewer people shopping from the traditional brick and mortar shops. This has created a shift in the way a business operates and the increased use of technology in the business.Such facts on rapidly changing shopping habits raise the following questions to answer in  this research paper:  What is the reason people purchase products online? What kind of products are bought frequently in internet? Is there any difference  in online purchasing among generations? The answer to these questions will help current retail companies adjust their businesses based on consumers’ behavior to online shopping. The study will be mainly based on relevant official statistics and other research findings.

Topic #2 Online education vs offline education: Like online shopping, there is a change in the way education is delivered these days. We have an array of online professional courses conducted by the institutes that offer a diploma and certification that has enhanced education to the next level.Technology is dramatically changing the education system globally from traditional classrooms to online learning; however, many students say they lean toward the traditional classroom setting. Decisions in education abound, and many guardians are interested in investigating all the choices.

While volunteering at an assisted living facility, you are asked to participate in the care of an 82 year-old female resident with limited mobility. When you are first introduced to Gladius Claymore, you notice she often rubs and taps at the side of her left hip, but still greets you with a welcoming smile. Gladius often spoke of experiencing shooting pain, numbness, and weakness on her lower back, the posterior side of her left buttocks, and her posterior lower limb. She first started experiencing these symptoms ever since she suffered a bad fall a few months back. “The doctor said I had a ‘slipped disc’ in my waist” she tells you “But I don’t get why it would make my thigh hurt!” You help Gladius make it to her physical therapy appointment and spend some time chatting with her clinician. When the clinician finds out you are taking a human anatomy class she begins to quiz you about some of the anatomy related to Gladius presentations and complications that might be associated with it. Gladius has a good time quizzing you too (and telling to when you’re wrong) and wishes you luck on your upcoming exam.          

Goal: Using the description above, describe the most likely diagnosis for Gladius’s presentation (should include anatomical terms), and compared it with an in-depth discussion of the normal, healthy anatomy (hint: should include tissue types found in the bone and joints in the vertebral column). Next, describe the common causes of this presentation, especially in someone of Gladius’ demographic group. Gladius’s presentation may cause impingement on components of the central and/or peripheral nervous system, describe those components using correct anatomical terminology. Describe the layers and spaces surrounding the spinal cord. Lastly, how might someone like you get involved with Gladius and brighten her day.           

• Design employee compensation programs taking into account organizational circumstances
• Propose amendments benefit programs to meet changing employee and employer needs
• Assess employer costs of benefit programs

Part of a human resource managers job is to analyze the benefits programs to ensure that an organization is compliant and that the costs are within budget. There are a number of required programs such as social security, worker's compensation insurance, unemployment insurance, health care, and FMLA leave. In addition to these mandated programs, many employers offer additional benefits such as dental, vision, disability, life insurance, tuition reimbursement, holidays, vacation, other paid time off (jury duty, bereavement, etc), 401(k) or other retirement, student debt support and more.

Managed by Q Case Benefits Analysis: In the case study we learn that Managed by Q offers free health insurance, 40 hours of paid vacation and a 401(k) plan. In addition, they would have to offer the legally required benefits such as worker's compensation and unemployment. The financial spreadsheet indicates there is a 20% markup for benefits and taxes. In year 5, therefore, we could surmise that of the $2,729,927 in wages and taxes, 20% or approximately $545,000, went to benefits and taxes.

1. Create an analysis of the provided benefits and taxes (both mandatory and discretionary) and create an academic, data-guided, proposal of any changes you might suggest to Managed by Q.
2. For this analysis, assume a 4% 401(k) match, FUTA rate of .06 (of first $7000), SUTA rate of .019 (of first $9000).
3. Be sure to incorporate items such as cost sharing or creative benefits such as student loan repayment options in your recommendations if appropriate.

Please answer question #3

Note: In this exercise you need to weigh out how many benefits you would like to offer verse the cost of those benefits. In your paper be sure to (1) explore the current benefit offering and (2) talk about what benefits you might offer and/or what changes you would recommend to Managed by Q.

Several studies suggest that breast-fed babies become more intelligent children than formula-fed babies. One such study (Mortensen, Michaelsen, Sanders, & Reinisch, 2002) involved a sample of over 3,000 women and men born in Copenhagen, Denmark, between October 1959 and December 1961. The samples were divided into five categories based on duration of breast-feeding, as assessed by physician interview with mothers at a one-year examination. The child’s intelligence was assessed using the Wechsler Adult Intelligence Scale (WAIS) at a mean age of 27.2 years. The results showed that duration of breast-feeding was associated with significantly higher scores on the verbal, performance, and full scale WAIS IAs. This difference was observed even after the researchers adjusted for differences in the social class and maternal education of the two groups. (This adjustment allowed the researchers to rule out any preexisting differences in the groups that might have independently contributed to IQ differences in their children.) The authors acknowledged that other differences between the groups, such as the children’s genetic potential or their parents’ caregiving skills or motivation to nurture, could explain the results. However, they believe that human milk contains various hormones and other factors that enhance brain growth and maturation.

1. State the research hypothesis in your own words and Identify variables a. Independent b. dependent variables

2. define all important concepts and terms as they are used in this study.

3. What evidence do the researchers offer as a test of their hypothesis? Is this evidence empirical (observable)? Is it valid?

4. What explanation do the researchers offer for their findings? Does this explanation make sense based on the evidence?

5. Given the results of this study, why can’t the researchers draw a causal connection between type of food and later intelligence?

6. What might be an alternative explanation for the results of this study?

7. What could the researchers do in order to make a causal connection between the dependent and independent variables?

8. Are there any practical implications for this research?

Julie W. is a junior dental hygiene student who had the misfortune to puncture her glove with a contaminated instrument. Although her patient tested negative for both hepatitis C and human immunodeficiency virus, the wound became badly infected. Her physician prescribed 500 mg of amoxicillin three times a day for 7 days, but at the end of 3 days, the infection is worse and is spreading. Julie feels too ill to attend classes, thus she returns to the college’s health center to see the physician again. Her temperature is 103.4° F, her pulse rate is 110 bpm, and her cervical lymph nodes are swollen. The physician is very concerned about the infection and admits Julie to the hospital. Her current medications include oral contraceptive pills and multivitamins.

13. What is the probable cause of the worsening infection? a. The antibiotic is not broad spectrum b. It is a viral infection c. The bacteria are resistant to the antibiotic d. All of the above

14. Julie should do which of the following. a. Begin taking pencyclovir b. Try another antibiotic to be prescribed by her physician c. Wait another 24 hours to see if she will respond d. Do nothing

15. When Julie goes home with an antibiotic, what advise should she be given? a. Continue taking the antibiotics until the prescription is finished b. Use alternative forms of contraception while taking antibiotics c. Take medications on an empty stomach d. All of the above e. a & b only

16. Julie should not worry about mixing antibiotics with oral contraceptives. True False

17. If Julie contracted a cold, which of the following would be true? a. The antibiotics will take care of the cold b. The cold will need to run its course c. The cold will require a different antibiotic than the infection d. None of the above

18. While on antibiotics, Julie contracts a superinfection. This means she has suppressed the normal flora, so a second infection can occur. True False

Virtue ethics addresses difficult issues such as the nature of life, the nature of death, what sort of life is worth living, what constitutes murder, how we should treat people who are especially vulnerable, and the responsibilities that we have to other human beings.

True
False

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Question 16 3 pts
Professional ethics are standards or codes of conduct established by the membership of a specific profession.

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False

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Question 17 3 pts
Compassion is a form of beneficence. People, often believing they know what is best for another, often make decisions they believe are in that person’s best interest.

True
False

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Question 18 3 pts
Negative tolerance implies one will reluctantly put up with another’s beliefs. In other words, they simply tolerate the view of others.

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False

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Question 19 3 pts
Crimes are established by legislative bodies.

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False

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Question 20 3 pts
Medicare is a federally sponsored health insurance program for persons over 65 years of age and certain disabled persons.
True
False

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Question 21 3 pts
Failure to conform to or a departure from a required duty of care owed to a patient is considered a breach of duty.

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False

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Question 22 3 pts
The plaintiff must establish a negligent act was newsworthy.

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False

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Question 23 3 pts
Public figures have more difficulty in pursuing defamation litigation than the average individual.

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False

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Question 24 3 pts
Slander is the intentional touching of another’s person in a socially impermissible manner, without that person’s consent.

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False

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Question 25 3 pts
A tort committed deliberately and based on the premise the defendant intended the harmful consequences of his or her behavior isa cohersion.

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False

Congestive Heart Failure

Activity One:

1)            Define preload, afterload, contractility, Frank Starling mechanism.

2)            Identify three factors that can change preload. Identify three factors that can change afterload.

3)            Describe what happens as filling volume increases, and how that affects pressure.

Activity Two:

1)            Describe reduced vs. preserved ejection fraction heart failure. Which gender is more likely to experience symptoms of CHF with exercise? Which gender is more likely to experience isolated systolic blood pressure increase? Support your answers with citation to either the course material or from online search for evidence-based practice.

2)            Compare left and right sided heart failure. What are the effects of each type of heart failure? Which type is a patient likely to experience first? Why? Which type can result in pitting edema? Which type can result in pulmonary edema?

Activity Three:

Consider this patient below. Identify the patients’ characteristics that put the patient at risk for congestive heart failure.

Sarah Freidan: 48 year old office worker, 5 feet 4 inches tall, weighs 190 lbs. Waist circumference 36 inches. Nonsmoker. No ETOH. Fasting blood glucose 155 mgt/dL. Triglycerides 200mg/dL. HDL-C 46 mg/dL. Blood pressure 148/80. Currently takes no medications.

Activity Four:

Identify pharmacologic agents for diuresis to reduce preload. Identify positive inotropes.   Identify phosphodiesterase inhibitors. Describe the mechanism of action of ACE inhibitors. Describe the mechanism of action of Human B-type natriuretic peptide. Describe the mechanism of action of Angiotensin II-receptor blockers.   Which of these agents is the most commonly used for left sided heart failure? Right sided heart failure?   You may use narrative writing or a table to answer these questions.  

Answer all questions with a true or false

2. Communication between provider and consumers affects every facet on the health continuum from health promotion and disease prevention to assessment, diagnosis, and treatment.

3. Treatment adherence leads to better health out- comes and no adherence places the patient at risk for poor recovery and dis- ease progression.

4. Treatment adherence refers to not only medication adherence but also compliance with appointment schedules, diet and exercise regimens, or lifestyle modifications.

5. The relationship of trust between patient and provider is built on the effectiveness of their communications.

6. Cancer and Diabetes are the example of chronic diseases.

7. Symptoms are not observable by provider.

8. NIH is stands for National Institute of Health

9. CDC is stand for Center for Disease Control

10. The information processing that goes on within the brain has three distinct steps.

11. Parasympathetic system involve the fight-flight mechanism

12. Sympathetic system involve the relaxation

13. Teach back is the approach of choice with patient who understand their treatment regimen

14. Member of most subculture in USA are more comfortable to talk about their health problems with providers.

15. IOM drafted a few reports to improve the healthcare quality in USA.

16. One of the most common modes of human communication involves the use of questions.

17. Questions are customarily the primary tool for healthcare providers because providers are diagnostically driven and are continually seeking to assess patients

18. Ruling-out questions include questions that seek clarity and are generally more direct

19. Interpretative questions are used to collect data.

20. Interpretive questions are used to give information.

21. Are you following the diet and exercise plan I gave you? This question is example of direct question.

22. There are three types of questions formats.

23. Multiple-choice questions do offers options to the patient; patient has the choice of what to follow.

24. “Do you want some water?” is the example of open-ended question.

25. Would you prefer to have your bath before or after breakfast?” is the example of open-ended question.

26. Two types of trust are general and specific. Bonus Question

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