RTY Company’s year-end balance sheet for 2018 and forecasted quarterly cash flows for 2019 are given below. Company always pays for its purchases one quarter after the purchase. 50% of all sales are collected in the current quarter and 50% in the next quarter. Other expenses are paid in the current quarter. a. Prepare the quarterly cash budget for the company for 2019. b. Assuming all forecasts will be accurate, how much external long-term financing will the company need if the company does not want to use any short-term financing at all?

Balance Sheet Year-end 2018 (million$) Assets Liablities Cash 5 Accounts Payable 40 Accounts Receivable 25 Inventory 70 Long-term Debt 160 Net Fixed Assets 400 Equity 300 Total Assets 500 Total Liabilities and Equity 500 2019 Forecasts (million $) Quarter 1 Quarter 2 Quarter 3 Quarter 4 Sales 50 20 120 30 Purchases 40 30 50 50 Other expenses 10 10 10 10

Today, one needs to pay 130 US dollars for 100 euros. The continuously compounded US interest rate is 1% and the continuously compounded euro interest rate is 2%.

(1) What is the 9-month forward price for 100 Euros?

(2) Suppose you will receive 2 mln US dollars and 1 mln. euros in six months. The current forward price of a forward contract that matures in six months is F0,6mth = 1.2935 USD per 1 euro. Suppose you short eight forward contracts today (the contract size is 125,000 Euro). How many USD and euros will you have in six months?

One state lottery has 1,000 prizes of $1; 130 prizes of $10; 20 prizes of $55; 5 prizes of $300; 2 prizes of $1,010; and 1 prize of $2,500. Assume that 31,000 lottery tickets are issued and sold $1

What is the lottery's expected profit per ticket?

What is the lottery's standard deviation of profit per ticket?

A sample of 40 observations is selected from a normal population. The sample mean is 31, and the population standard deviation is 3. Conduct the following test of hypothesis using the 0.05 significance level.

H₀: μ ≤ 30

H₁: μ > 30

1. Is this a one- or two-tailed test?

• "One-tailed"—the alternate hypothesis is greater than direction.

• "Two-tailed"—the alternate hypothesis is different from direction.

2. What is the decision rule? (Round your answer to 3 decimal places.)

3. What is the value of the test statistic? (Round your answer to 2 decimal places.)

4. What is your decision regarding H₀?

• Do not reject

• Reject

1. e-1. What is the p-value? (Round your answer to 4 decimal places.)

1. e-2. Interpret the p-value? (Round your answer to 2 decimal places.)

(1) Read in the data and create an R data frame named tennis.dfr 
that has the following names for its columns:  first.name, last.name,
major.match.wins, major.match.losses, overall.match.wins, 
overall.match.losses, major.titles, overall.titles.  (Note that the 
data file has several explanatory lines before the real data begin 
that should be skipped when reading in the data lines.)
NOTE:  For the file name, you must use the following web address (URL): 
"http://people.stat.sc.edu/hitchcock/tennisplayers2018.txt".  
Please do not have your code read in the file from your own personal directory.

(2) Create and add two more columns called major.winning.pct and 
overall.winning.pct (showing winning percentage in the "major" and 
"overall" categories, respectively) to this data frame.
  
Note that "winning percentage" is defined 
as (match wins)/(match wins + match losses).

(3) Sort the data frame by major titles, from most to least.  
Have your program print the sorted data frame.

(4) Perform a nested sort, sorting the data frame first by major
titles (from most to least), and then by major winning percentage 
(from most to least) within major-title levels.
Have your program print this sorted data frame.

(5) Have R extract the subset of the data frame consisting of players
with at least 6 major titles.  Call this new data frame: greatest.dfr
Have your program print this new data frame.

(6)  In the most efficient way possible, have R calculate the sample means 
for each of the numeric variables in the tennis.dfr data set.
(Hint: Extract the appropriate subset of the data frame first.)

(7) Use the write.table() function to write the data set tennis.dfr to an
external file simply called "tennisdata.txt".  Make sure the external file includes the column names.
Also, make sure the players' names are NOT surrounded by quotes in the 
external file.

Question 1

What post-translational modification will cause the biggest increase in the size of a protein, immediately when added?

Select one:

a. Phosphorylation

b. Ubiquitination

c. Acetylation

d. Methylation

Question 2

What does HMT do?

Select one:

a. It acts as an epigenator

b. It modifies nitrogenous bases

c. It produces euchromatin

d. It modifies histones

Question 3

Where can an epigenetic maintainer act?

Select one:

a. On the sequence of nucleotides

b. On the sequence of nucleotides and on the nucleotides directly

c. On certain nucleotides and amino acids

d. On certain amino acids

e. On certain nucleotides

Question 4

Which of the following types of protein could be coded by a tumour-suppressor gene?

Select one:

a. A protein that stimulate progression through the cell cycle.

b. A protein that forms part of a growth factor signaling pathway.

c. A protein that codes for a DNA repair enzyme.

d. A protein that helps prevent apoptosis.

e. A protein that repairs lost telomeres

Question 5

Which is NOT a typical mechanism by which a proto-oncogene is converted to an oncogene?

Select one:

a. A point mutation in the proto-oncogene

b. A chromosomal translocation resulting in the up-regulation of the proto-oncogene

c. Duplication of a chromosome region containing a proto-oncogene

d. Complete deletion of the proto-oncogene

e. Amplification of the proto-oncogene

Question 6

Why do you think familial retinoblastoma and Li-Fraumeni are considered to be inherited as autosomal dominant traits when the responsible genes are recessive?

Select one:

a. They are expressed in a dominant fashion in males, but recessive in females.       

b. People with this mutation are always homozygous for this allele.

c. If you are born with one allele mutated in every cell, the chance that the other allele will be mutated in one of the retinal cells is extremely high.

d. This recessive gene needs only one copy to express this phenotype.

e. Retinoblastoma was mischaracterized originally when it was called an autosomal dominant trait.

Question 7

Question text

In a normal cell, pRB binds to __________, which inhibits cell division. In the presence of __________ pRB becomes __________, which leads to cell division.

Select one:

a. cyclin+Cdk; oncogenes; dephosphorylated

b. transcription factors; cyclin+Cdk; phosphorylated

c. tumor suppressor; p53; phosphorylated

d. p21; p53; dephosphorylated

e. tumor suppressor; p21; hyperactive

Question 8

The following information relates to the next three questions:

A few decades ago, Knudsen and colleagues proposed a theory that, for a normal cell to become a cancer cell, a minimum of two genetic changes had to occur in that cell. Knudsen was studying retinoblastoma, a childhood cancer of the eye.

Two children are born from the same parents. Child one inherits a predisposition to retinoblastoma (one of the mutations) and child two does not. However, both children develop the retinoblastoma. Which of the following would you expect?

Select one:

a. a history of exposure to mutagens in child one but not in child two

b. increased levels of apoptosis in both children

c. an earlier age of onset in child one

d. decreased levels of DNA repair in child one

e. a more severe cancer in child one

Question 9

In colorectal cancer, several genes must be mutated in order to make a cell a cancer cell, supporting Knudsen’s hypothesis. Which of the following kinds of genes would you expect to be mutated?

Select one:

a. genes that are especially susceptible to mutation

b. the same genes that Knudsen identified as associated with retinoblastoma

c. genes coding for enzymes that act in the colon

d. the genes of the bacteria that are abundant in the colon

e. genes encoding transcription factors that regulate cyclin production

Question 10

Knudsen and colleagues also noted that persons with hereditary retinoblastoma that had been treated successfully lived on but then had a higher frequency of developing osteosarcomas (bone cancers) later in life. This provided further evidence of their theory because:

Select one:

a. osteosarcoma cells express the same genes as retinal cells.

b. one of the mutations involved in retinoblastoma is also one of the changes involved in osteosarcoma.

c. p53 gene mutations are common to both tumours.

d. retinoblastoma is a prerequisite for the formation of osteosarcoma later in life.

e. both kinds of cancer involve uncontrolled proliferation of cells.

Mr. Chung has smoked two packs of cifarettes per day for 50 years. ABGs reveal a liw PO2 and a high PCO2 consitent with chronic lung disease. He is diagnosed with an acute exacerbation of chronic bronchitis. He is placed on oral antibiotics and long acting bronchodilators by metered dose inhaler. What teaching could you offer to help Mr. Chung mobilize and expectorate secretions?