A 53-year-old newly married male had just returned from Mozambique where he spent his honeymoon. Two weeks later, he developed nausea and vomiting, abdominal pain, high fever and chills. He was admitted to hospital where thrombocytopenia and spleen enlargement were observed. When a diagnostic test was done, it revealed positive results indicating an infection with Plasmodium falciparum, and he was immediately treated with IV chloroquine.

a. Which disease can be caused by P. falciparum?

b. Discuss the plasmodium lifecycle in human host.

c. At which stage of the plasmodium life cycle does an infected person present with clinical manifestations of malaria?

d. Describe the mechanism of action of chloroquine.

e. Describe one chemoprophylactic drug that the patient could have taken prior to visiting Mozambique and the duration thereof.

Background: You are the Director of Communications for a large Canadian-based multinational Fortune 500 corporation. It is your responsibility to write the company blog that is posted on the internet for all stakeholders and the general public to review. The Blog Worksheet outlines four scenarios (situations) for which you must post a response.

When writing your blog posts, you must consider the following:

1. The subject matter and whether it is a good news or bad news story;
2. The appropriate tone for your message to ensure consistency;
3. The human side and the audience of your message. Note the scenario above states that it is a public blog. Consider who will read a public blog and who will be the primary audience.
4. The length and the importance of being succinct (Though the average blog length averages between 500-1,000 words, for the purposes of this assignment, keep each of your postings to a maximum of 250 words).

J.M. is a 26-year-old man, who is known to be an IV drug user. His veins are badly sclerosed because of years of abuse. He needs an HIV (human immunodeficiency virus) test, HBV (hepatitis B virus) test, and HCV (hepatitis C virus) antibody test. Dennis, the phlebotomist, is able to locate a vein in the hand on a second attempt using a butterfly needle. As Dennis is withdrawing the needle, the patient suddenly jerks his hand. Drops of blood spatter on Dennis’ lab coat and he is accidentally stuck in the finger by the needle.

1. What should be Dennis’ immediate response?
2. What subsequent steps need to be taken?
3. What type of diseases do HIV and HCV cause? What are the initial symptoms? How are these diseases diagnosed?
4. Should Dennis be concerned about the blood on his lab coat?

5. Bill has come to you for genetic counseling. He is concerned that he and his sister (Alice) are at risk for Huntington disease. Bill and Alice are too young to show symptoms. Their grandmother, (Mary) had Huntington disease. Her three children, Shirley, Tom, and Ed so far show no symptoms. Shirley is the oldest (45 years old) and is Bill and Alice’s mother. A study by Adams (American Journal of Human Genetics 43;695 – 704, 1988) indicates that 68% of individuals heterozygous for the Huntington allele show symptoms by age 45.

a. Draw a pedigree of this family.

b. What is the probability that Bill is heterozygous for Huntington disease?

c. What test(s) would you recommend for Bill and Alice to determine if they are heterozygous?

d. Explain why you recommend this test, what results it can give, and how these results can answer Bill’s question. PLEASE BE SPECIFIC

1. Three pairs of genes with two alleles each (A1 and A2, B1 and B2, and C1 and C2) influence lifespan in a human population. The alleles of these genes have an additive relationship and add the number of years indicated to the lifespan of the individual.

a. If lifespan were entirely genetically determined, what is the minimum possible lifespan and the associated genotype?

b. If lifespan were entirely genetically determined, what is the maximum possible lifespan and the associated genotype.

c. The following is a range of ages from individuals in this population. If the genetic variance is 25.7, measure the broad-sense heritability of lifespan

d. Explain what this heritability means, and why the measure may be so low.

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The Air Marshal Co. has recently completed a $10,000,000 two-year marketing study.  Based on the results of this study, Air Marshal has estimated that 800 units of its new security electro-optical human scanning hardware, known as "Marshal Dillon," could be sold annually over the next 12 years, at a price of $110,000 the first year with an estimated 2% annual rise from inflation in years 2-6.  The sales price is expected to drop to $90,000 in year 7 due to increasing competition with 2% annual increase for year 8-12.  Variable costs per unit are $45,000 with an estimated 4% annual rise from inflation in years 2-12 and incremental cash fixed costs total $15 million per year all 12 years.   

Until the mid-eighteenth century when spinning became mechanized, cotton was an expensive and relatively unimportant textile (Virginia Postrel, “What Separates Rich Nations from Poor Nations?” New York Times, January 1, 2004). Where it used to take an Indian hand-spinner 50,000 hours to hand-spin 100 pounds of cotton, an operator of a 1760s-era hand-operated cotton mule-spinning machine could produce 100 pounds of stronger thread in 300 hours. When the self-acting mule spinner automated the process after 1825, the time dropped to 135 hours, and cotton became an inexpensive, common cloth.

Provide two examples in a recent human experience that parallel's what you have read about cotton clothing.

Explain how the two examples of recent experience are similar to what you have read.

Your organization is an organic food supplier with employees in the following jurisdictions:

Manitoba

Prince Edward Island

Yukon

The organization is planning to implement a company-wide policy with respect to vacation leave and vacation pay that provides the same benefits to all employees, regardless of their province of employment. As the Payroll Supervisor, provide Susan Fraser, the Human Resources Manager, with the following information:

Identify four specific items relating to vacation leave and vacation pay that will have to be addressed in the policy to ensure compliance with the employment/labour standards in each jurisdiction.

Research the details for each of the items you have identified using the course material and the employment/labour standards website for each jurisdiction.

Using the results of your research, provide your recommendations to Ms. Fraser on how to address each of these items in the policy to provide the employees with the best benefit, while keeping the cost to the organization at a minimum. Explain your reasoning.

1- During infancy, development of muscular coordination and strength generally occurs from the head to the “tail,” or from the top to the bottom. This is called:

2-

Most human neurons have two structures that are for sending and receiving messages. These are called:

1. Millions faced famine and required emergency aid

2. The world emitted historic amounts of carbon

3. Natural disasters dominated the news

4. Two-thirds of global wealth is human capital

5. There’s a crisis in learning

6. Nutrition affects learning, and millions of children remain stunted

7. Child marriage carried high personal and economic costs

8. The world’s population is young. And jobless.

9. Natural capital and biodiversity are undervalued

10. Globally, about half of elections are considered free and fair

11. Starting a business is getting easier

12. The power of renewables

1. Which of the 12 trends contribute to the reduction in the world poverty? Why?
2. Which of the 12 trends contribute to the increase in the world poverty? Why?
3. Which trends you've found most important, concerning, or surprising? Why?