Determine the Vmax and the Km of the enzyme in the absence and presence of each inhibitor. Calculate the KI for each inhibitor. Are the inhibitors all the same? Which is the best inhibitor and why? What is the catalytic efficiency and turnover number of the enzyme knowing that during the experiments its concentration was 2 nM? What happens to the catalytic efficiency and turnover number of the enzyme in the presence of each of the inhibitor?

The following velocity data were obtained for an enzymatic reaction in the absence and presence of three different inhibitors (A, B, and C):

Initial velocity (v) Initial velocity (v) Initial velocity (v) Initial Velocity (v)

[S] Control (no inhibitor) (+A at 6μM) (+B at 30μM) (+C at 4mM)

(mM) (nM/min) (nM/min) (nM/min) (nM/min)

0.200 16.67 6.25 5.56 10.00

0.250 20.00 7.69 6.67 11.11

0.333 24.98 10.00 8.33 12.50

0.500 33.33 14.29 11.11 14.29

1.00 50.00 25.00 16.67 16.67

2.00 66.67 40.00 22.22 18.18

2.50 71.40 45.45 23.81 18.52

3.33 76.92 52.63 25.64 18.87

4.00 80.00 57.14 26.67 19.00

5.00 83.33 62.50 27.77 19.23

1. Suppose 50.00 mL of 2.0 × 10–4 M Fe(NO3)3 is added to 50.00 mL of 2.0 ×10-6 M KIO3. Which of the following statements is true? For Fe(IO3)3, Ksp = 1.0 × 10–14.
A) A precipitate forms because Qc > Ksp.
B) A precipitate forms because Qc < Ksp.

C) No precipitate forms because Qc < Ksp.

D) No precipitate forms because Qc = Ksp.

E) No precipitate forms because Qc > Ksp.

2. For which of the following reactions is ∆S° > 0 at 25°C?

A) 2H2(g) + O2(g) → 2H2O(g)
B) 2ClBr(g) → Cl2(g) + Br2(g)
C) I2(g) → I2(s)

D) 2NO(g) + O2(g) → 2NO2(g)

E) NH4HS(s) → NH3(g) + H2S(g

3. What is E of the following cell reaction at 25°C? Cu(s) | Cu2+(0.017 M) || Ag(s), (Ag+ = 0.18M)

E°cell = 0.460 V.

A) 0.468V

B) 0.282 V

C) 0.460 V

D) 0.490 V

E) 0.479V

Assume that the following relationship holds:

Maintenance Costs = (v * Machine Hours) + f

REQUIRED

Estimate the values of v and f and the cost equation, using,

1. the High-Low Method, and

Make sure to report

1. The values of v and f;

2. A scatter plot of the data points, and

3. The adjusted R-square; explain what the adjusted R-square means.

4. The cost equation in the form of Y = vx + f, substituting the values for v and f from the regression output.

YOUR SUBMISSION MUST BE IN EXCEL.  

An object of irregular shape has a characteristic length of L = 1 m and is maintained at a uniform surface temperature of T_s = 325 K. It is suspended in an airstream that is at atmospheric pressure (p = 1 atm) and has a velocity of V = 100 m/s and a temperature of T_? = 275 K. The average heat flux from the surface to the air is 12,000 W/m². Referring to the foregoing situation as case 1, consider the following cases and determine whether conditions are analogous to those of case 1. Each case involves an object of the same shape, which is suspended in an airstream in the same manner. Where analogous behavior does exist, determine the corresponding value of the average heat or mass transfer convection coefficient, as appropriate.

(a) The values of T_s, T_?, and p remain the same, but L = 2 m and V = 50 m/s.

(b) The values of T_s and T_? remain the same, but L = 2 m, V = 50 m/s, and p = 0.2 atm.

(c) The surface is coated with a liquid film that evaporates into the air. The entire system is at 300 K, and the diffusion coefficient for the air–vapor mixture is D_AB = 1.12 × 10^?4 m²/s. Also, L = 2 m, V = 50 m/s, and p = 1 atm.

(d) The surface is coated with another liquid film for which D_AB = 1.12 × 10^?4 m²/s, and the system is at 300 K. In this case L = 2 m, V = 250 m/s, and p = 0.2 atm.

Challenge Lab 8-1: Configure Network Settings in Hyper-V

Your Windows Server 2012 R2 server is installed in a VM named VMTest1 that you created in the hands-on projects. You are ready to perform post-installation tasks. One of the things you will need to do is configure the virtual network. Do a little research on configuring the virtual network in Hyper-V. Open Hyper-V Manager and study the configuration tasks you can perform in the Actions pane.

You should configure the virtual network so that VMs you are running in Hyper-V can communicate with each other and with the host computer. You will need to perform two steps to configure the virtual network. You will also need to configure the Windows Server 2012 R2 VM with an appropriate IP address to communicate with the host computer. You should test communication between the physical computer and the host computer using the Ping utility. When you are finished, answer the following questions:

Discussion Questions

a. What setting in Hyper-V did you access to configure the virtual network?

b. What type of virtual network did you configure?

c. After you configured the virtual network, what did you have to do to make sure your VM used the virtual network?

d. What IP address did you configure on your VM? What command did you use to ping the host computer?

Federal courts may hear cases that originate and really only pertain to state law when there is diversity of citizenship between the plaintiff and defendant. The Gasperini case is one such case. In the case, the federal court was compelled to apply state law, not federal law. This is due to which famous case?

In Smith v. Massachusetts, Justice Ginsberg bases her dissent upon what issue

The best way to describe the relationship between the fifth and sixth amendments is

Complete this statement: the Seventh Amendment is most similar to which amendment in application:

Use the following information to answer problems 1 through 5: Han Solo guesses randomly at

six multiple choice questions on an exam. Each question has four potential answers.

Page

2

of

2

7. This scenario can be modeled as a

(a) normal experiment with 4 trials and success probability of 1/6 per trial.

(b) normal experiment with 6 trials and success probability of 1/4 per trial.

(c) binomial experiment with 6 trials and success probability of 1/5 per trial.

(d) binomial experiment with 4 trials and success probability of 1/6 per trial.

(e) binomial experiment with 6 trials and success probability of 1/4 per trial.

8. Complete the following table that represents the probability distribution of

X

= the number of

questions Han guesses correctly.

x

0

1

2

3

4

5

6

P(X = x)

(a) 1/7, 2/7, 3/7, 4/7, 5/7, 6/7, 1

(b) .1780, .5339, .8306, .9624, .9954, .9996, 1

(c) 1/7, 1/7, 1/7, 1/7, 1/7, 1/7, 1/7

(d) .1780, .3560, .2966, .1318, .0330, .0044, .0002

(e) 1/6, 1/6, 1/6, 1/6, 1/6, 1/6

9. What is the probability he will answer at least 4 of the questions correctly?

(a) 0.0376 (b) 10/12 (c) .67% (d) 2/12 (e) 0.0046

10. What is the mean number of questions he will answer correctly?

(a) 0 (b) 1 (c) 1.5 (d) 2 (e) 4

11. What is the standard deviation of the number of questions he will answer correctly?

(a) 0.46 (b) 1 (c) 1.06 (d) 1.5 (e) 1.6

Suppose you are the Chief Marketing Officer for a retailer that has data on the home addresses of its

1,000,000 most active customers. You hope to determine whether sending out “20% off your entire

purchase” coupons by mail will increase revenues.

You conjecture that customers who have access to this coupon will spend more in the store over the

next year. However, skeptics in your company argue that the coupons will just allow customers to

spend less on items they would have purchased anyway. This is a debate that an experiment can

resolve.

In thinking about how large of an experiment you need to have enough statistical power, you realize

that many of the customers you send the coupons to in the mail will not open the mail and so will not

realize they received the coupon.

1. The CEO argues that to estimate the effects of the coupons on revenue, you should compare

the difference in revenues from a) people you sent the coupons and who used them and b)

people you sent the coupons but who did not use them. Write a response to your CEO:

describe the flaw with this plan in language the CEO will understand, and advocate for your

proposed experiment.

2. To avoid the cost of sending out coupons you do not need to, you ask the data science team

to plan an experiment just large enough (with just enough statistical power) to reliably detect

a treatment effect if the true effect on those who open the mail and realize they have the

coupon is a $2 increase in revenue over the next year. The data science team tells you that

an experiment with 100,000 people in the treatment group (leaving the remaining 900,000 in

the control group) will be well-powered to detect an overall difference between the entire

treatment and control groups of $2 in revenue over the next year. To send out the minimum

number of coupons required while still having enough statistical power to detect a $2 effect of

opening the mail, can you send out fewer, the same number of, or more coupons than

100,000?

A _________________ is an important characteristic related to the response variable which, when unaccounted for, may lead researchers to false conclusions about cause and effect.

Question 2 options:

In a double-blind experiment conducted to study the effectiveness of a new drug to relieve the common cold, a participant was given a sugar pill. After taking the pill, she finds she can breathe more easily, and her condition substantially improved. Which of the following describes this phenomenon?

Question 4 options:

Question 5 (1 point)

Statistics can be an ‘art’ as different statisticians may use different methods of analysis in answering questions pertaining to a study.

Question 5 options:

Question 6 (1 point)

Researchers want to test a new type of surgical procedure. Individuals are randomly placed in one of two groups. Ten individuals receive the new surgery, while the other 10 individuals receive the old surgery as a control. The participants do not know which surgical procedure they receive. Researchers are aware of which individuals are placed in each group. Which of the following characteristics of a controlled experiment has not been satisfied?

Question 6 options:

Question 7 (1 point)

Which of the following would not necessarily be considered one of the four principles of good practice in a controlled experiment?

Question 7 options:

n 2016, Gerald loaned Main Street Bakery $55,000. In 2017, he learned that he would probably receive only $6,400 of the loan. In 2018, Gerald received $3,000 in final settlement of the loan. Calculate Gerald’s possible deductions with respect to the loan for 2016, 2017, and 2018.