Think of a toy model of a dimeric receptor binding with a divalent ligand. The KDs for binding between a two-armed compound LL1 (this is the ligand) and individual receptors R1 and R2 are:
R1 … 7.9 nM R2 … 50.1 nM
Now think of a protein R1-R2, which is a protein comprised of both R1 and R2. At a temperature 300K, if there is no loss of energy/entropy to induce conformational changes of the protein and ligand during the binding, what is the expected KD between LL1 and R1-R2 and corresponding deltaG?
In: Biology
Even before the structure of DNA was solved, studies indicated that the genetic material must have the following properties:
• be able to store information;
• be faithfully replicated and be passed on from generation to generation; and
• allow for changes, and thus evolution, to occur.
1: Explain how the structure of the double helix showed that DNA had these properties. Write one or two sentences per point.
2:Linus Pauling's model was wrong because it didn't ?
3: he tried to build the structure with what information?
In: Biology
How to connect lung cancer with the following:
C1. analyse the economic and environmental advantages and
disadvantages of an artificial selection
technology, and evaluate the impact of environmental changes on
natural selection and endangered species;
C2. investigate evolutionary processes, and analyse scientific
evidence that supports the theory of evolution;
C3. demonstrate an understanding of the theory of evolution, the
evidence that supports it, and some of the
mechanisms by which it occurs.
We have to write an essay with these categories, please give some idea and explain what each mean to me.
In: Biology
A) Explain why the total return from holding a bond to maturity will be between the yield to maturity and the reinvestment rate.
B) For a long-term high-yield coupon bond, do you think that the total return from holding a bond to maturity will be closer to the yield to maturity or the reinvestment rate?
C) What are the limitations of using duration as a measure of a bond’s price sensitivity to interest rate changes?
D) Does convexity of a bond have investment implications? Carefully reason out your answer.
In: Finance
In: Statistics and Probability
1. Describe the major areas of organizational change that have
impacted Holden. How are managers at Holden managing the types of
changes?
2. A focus and goal of Holden is to be at the forefront of
fashionable outerwear. Explain the role of innovation and how this
has impacted Holden as an organization.
3. Pretend you are working as a manager for Holden and identify a main area of change Holden is managing on a regular basis. Using the seven steps in the change process, outline a proposed plan that describes what change is needed and why it must be implemented.
In: Operations Management
Which of the following events would strengthen the argument for the use of monetary policy and weaken the argument for the use of fiscal policy?
I. Investment spending becomes more sensitive to changes in interest rates.
II. A balanced budget amendment is passed and made effective.
III. International trade and financial flows become a more important part of the U.S. economy.
A I only
B II only
C I and II only
D II and III only
E I, II, III
In: Economics
Doug is a 56-year-old tri-athlete. A recent physical
revealed that his blood levels of homocysteine were elevated. His
doctor suggested improving his diet to lower his homocysteine
levels. Doug schedules an appointment with you to learn more about
the dietary changes required to lower his blood levels of
homocysteine.
Adequate consumption of which vitamins may help Doug decrease his
homocysteine levels? Name three foods or beverages that are rich
sources of these vitamins.
In: Biology
Suppose you need a 5-year mortgage loan to purchase a house that worth $450,000. The bank offers two interest rate options for you to choose:
(i). Fixed rate at 3.5%. Interest rate will remain fixed for that loan's entire term, no matter how the market interest rate changes.
(ii). Variable rate which varies with market interest rate and is typical 1.5% above the market interest rate.
Which one would you choose? Briefly explain why.
In: Finance
1) Answer the following the questions regarding an acetic acid buffer solution.
a) A solution was prepared by dissolving 0.024 moles of acetic acid (HOAc; pKa =4.8 ) in water to give 1 liter of solution. What is the pH?
b)Then 0.009 moles of sodium hydroxide (NaOH) was added in to the solution. What is the pH of the solution? (In this problem, you may ignore changes in volume due to the addition of NaOH)
c)Additionally, 0.015 moles of NaOH is then added to the solution (2). What is the pH of the solution?
In: Chemistry