2. There is a large area of Bangladesh where the groundwater is contaminated by arsenic. Residents of this area suffer from elevated rates of cancer, and of pre-cancerous skin lesions, because they often have no alternative but to drink the arsenic-contaminated water. Many efforts are underway to solve this problem. In one study, investigators looked for evidence that the effect of arsenic on pre-cancerous skin lesions might be increased or decreased by other factors – effect modifiers. One such possible factor is pesticide use which is common in this agricultural region. The table shows the results of a 6-year closed prospective cohort study in which residents were followed and periodically examined for the occurrence of pre-cancerous skin lesions. All these people are exposed to arsenic in drinking water, and so this table does not show that exposure. These data divide the cohort into 3 groups based on how long they were exposed to pesticides. a. b. c. d. a. What measure of disease frequency can be calculated in these data? b. Calculate this measure for each of the 3 exposure groups. c. For the group with no pesticide exposure, calculate a 95% confidence interval for the measure of disease frequency. What does this interval mean? d. Calculate a ratio measure of association, comparing the risk of skin lesions in those with less than 7 years of exposure to those with no exposure, and another measure of association comparing those with 7 and over years of exposure to those with no exposure. Interpret these 2 measures of association. e. Is there evidence that pesticide exposure affects the risk of skin lesions in this population? Explain.

Applying the Scientific Method to an Experimental Study---

Your friend claims that sunlight affects the temperature of water

^^ I need to develop an experiment to test this claim

What is the Null and alternative hypothesis ???

1. Identify the Independent variable for your experiment.

2. Identify the Dependent variable for your experiment.

3. List at least 3 variables that you would hold constant in your experiment.

4. Now design the experiment: Identify and use at least five of the following lab equipment pieces to design your experiment. Provide a brief description of the experiment. Include a description of the Control Treatment and the Experimental Treatment

DNA experiment

What was Fredrick Griffith’s experiment and how was it relevant?

Diagram the experiment in detail.

Let X ∈ L(U, V ) and Y ∈ L(V, W). You may assume that V is finite-dimensional.

1)Prove that dim(range Y) ≤ min(dim V, dim W). Explain the corresponding result for matrices in terms of rank

2) If dim(range Y) = dim V, what can you conclude of Y? Give some explanation

3) If dim(range Y) = dim W, what can you conclude of Y? Give some explanation

Consider this code: "int v = 20; --v; System.out.println(v++);". What value is printed, what value is v left with?

20 is printed, v ends up with 19
19 is printed, v ends up with 20
20 is printed, v ends up with 20
19 is printed, v ends up with 19
cannot determine what is printed, v ends up with 20

1. Let V and W be vector spaces over R.

a) Show that if T: V → W and S : V → W are both linear transformations, then the map S + T : V → W given by (S + T)(v) = S(v) + T(v) is also a linear transformation.

b) Show that if R: V → W is a linear transformation and λ ∈ R, then the map λR: V → W is given by (λR)(v) = λ(R(v)) is also a linear transformation.

c) Let E(V) be the set of all linear operators T: V → V. Check that E(V) is a vector space with the addition and scalar multiplication defined above.

d) Suppose dim V = n. What is dim(E(V))? Justify your answer.

2. Protein purification
a) Determine the subunit composition of a protein from the following information:

Molecular Mass by Gel Filtration: 200 kD

Molecular Mass by SDS-PAGE: 100kD
Mass by SDS-PAGE with 2-mercaptoethanol

   40kD and 60 kD

b) In what order would E, H, and V be eluted from a DEAE column at pH 8?

c) You have a mixture of 3 proteins, one is 100 amino acids long, another 350 amino acids long, and the third is 600 amino acids long. Sketch the chromatogram ( a plot of elution time/volume as a function of A280) for a gel filtration chromatography experiment to separate these three proteins. Assume each protein is equally abundant and has a statistically normal number of tryptophans.

d) what would you do to validate the chromatographic observations in c) above?

*Please answer b thru d*

. A student carried out the electrolysis of a copper electrode in an electrolysis cell like the one employed in this experiment. The student weighed the electrode before the electrolysis and found its mass to be 35.251 g. During the electrolysis, a total volume of 96.30 mL of H2 was produced. Following the electrolysis the electrode had a mass of 35.008 g. The temperature in the laboratory was 25.2C and the barometric pressure was 975 mbar. 1 mol of H2 requires the passage of ________ faradays of charge. Loss in mass by anode _________________ g Equivalent mass of metal ___________________ g Molar mass of copper ___________________ g Charge, n, on cation ______________ Barometric pressure (1 atm = 1013.25 mbar) __________ mbar = __________ atm Temperature, T ___________ C = ____________ K Vapor pressure of H2O at T __________ mm Hg = __________ atm Partial Pressure of dry H2 ______________ atm Total volume of H2 produced, V __________ mL = __________ L

The following trial balance relates to KWEMPE at 31 March 2016:
                                                                                                                                                                                           $,000 DR                              $,000 CR
Equity shares of 50 Cents each ( note (V) )                                                                                                                                        50,000 CR
                                                                                                                                                                                                            Share    Premium 20,000 CR                                                                                                                                                                                                                                  
Retained earning 1 April 2015                                                                                                                                       11,200 CR
Land & Building - at cost ( Land $10 Million ) (note (ii) )                                 60,000 DR
Plant & Equipment - at cost ( note (ii) )                                                         94,500 DR
Accumulated depreciation at 1 April 2015: - Building                                                                                                                            20,000 CR
                                         - Plant & Equipment                                                                                                                                  24,500 CR
Inventory at 31 March 2016                                                                               43,700 DR
Trade receivables                                                                                             42,200 DR
Bank                                                                                                             6,800 DR
Defered tax ( note (iv) )                                                                                    6,200 DR
Trade Payables                                                                                               35,100 DR
Revenue ( note (i) )                                                                                         550,000 DR
Cost of Sales                                                                                                 411,500 DR
Distribution Costs                                                                                              21,500 DR
Administrative expenses                                                                                    30,900 DR
Dividends paid                                                                                                   20,000 DR
Bank Interest                                                                                                         700 DR
Current tax ( note (iv) )                                                                                                                                                             1,200 CR
Total          $750,000 DR $750,000 CR                                                                                                                                                                                                         

The following notes are relevant:
(i) Revenue includes the sales of $10 million of maturing inventory made to Xpede on 1 October 2015. The of the goods at the date of sale was 7million and KWEMPE has an option to repurchase these goods at any time within three years of the sale at a price of $10 million plus accrued interest from the date of sale at 10% per annum. At 31 March 2016 the option had not been exercised, but it is highly likely that it will be before the date it lapses.
(ii) Non- Current assets: On 1 october 2015, KWEMPE terminated the production of one of its product lines. From this date, the plant used to manufacture the product has been actively marketed at an advertised price of $4.2 million which is considered realistic. It is included in the trial balance at a cost of $9 million with accumulated depreciation ( at 1 April 2015 ) of $5 million.

On 1 April 2015, the Director of KWEMPE decided that the financial statements would show an improved position if the land and buildings were revalued to market value. At that date, an independent valuer valued the land at $12 million and the buildings at $35 million and these valuations were accepted by directors. The remaining life of the buildings at that date was 14 years. KWEMPE does not make a transfer to retained earnings for excess depreciationtion. Ignore defered tax on the revaluation surplus.
Plant and equipment is depreciated at 20% per annum using the reducing balance method and time apportioned as appropriate. All depreciation is charged to cost of sales, but none has yet been charged on any non - current asset for the year ended 31 March 2016.
(iii) At 31 March 2016, a provision is required for directors' bonuses equal to 1% of revenue for the year.

(iv) KWEMPE estimates that an income tax provision of $27.2million is required for the year ended 31 March 2016 and at that date the liability to deferred tax is $9.4million. The movement on deferred tax should be taken to profit or loss. The balance on current tax in the trial balance represents the under/over provision of tax liability for the year ended 31 March 2015.

(v) On 1 july 2015, KWEMPE made and recorded a fully subscribed rights issue of 1 for 4 at $1.20 each. Immediately before this issue, the stock market value of KWEMPE's shares was $2 each.

Required:
( a ) (i) Prepare the statement of profit or loss and other comprehensive income for KWEMPE for the year ended 31 March 2016.
       (ii) Prepare the statement of changes in equity for KWEMPE for the year ended 31 March 2016.
       (iii) Prepare the statement of financial position of KWEMPE for the year ended 31 March 2016.

    Note: Notes to the financial statements are not required.
( b ) Calculate the basic earnings per share for KWEMPE for the year ended 31 March 2016.

( c ) During April 2016, the KWEMPE land and building were hit by a storm and severely damaged. One of the directors has approached you, asking about how this damage should be accounted for:
' I ' ve been reading something online which tells me the building may be impaired. I don't know what that means, so I'II need you to explain it to me;
Required:
Explain when an impairment review is required and how any impairment is calculated, showing how any impairement adjustment is made in the finacial statements. Your answer should make specific reference to the KWEMPA land and buildings.

Note: DR stands for Debit side and CR stands for Credit side as well.

1. You want to conduct an experiment to understand how the power generated by a wind turbine is affected by the speed of the wind. Write your hypothesis (1point) and explain how you can conduct the experiment (assume that you’re in laboratory conditions like we preformed the Wind Turbine experiment) eg the experiment needed and the procedure of the experiment (1 point). Which parameters/conditions in the experiment should be kept under control and which parameters should be observed to test the hypothesis? (1 point)