In a negatively supercoiled circular plasmid (covalently closed), the transition of a small region of B-DNA to Z-DNA can be induced. If this region involves a 12 base pair alternating d(CG) sequence in the closed plasmid, determine changes to W, T, and L after the induced B-to-Z transition. (Remember: ~10 base pairs per right-handed turn for B-DNA and -12 base pairs per left-handed turn for Z-DNA, i.e. Z-DNA twists in the opposite direction).

In this module, you have learned about various economic markets including goods that a government does not allow to be sold in a market. Do you believe there should be limitations of these items?  For example, should there be a market for human kidneys? If people can sell their sperm or their eggs, why should kidneys be any different?

• Define demand, supply, and equilibrium in markets for goods and services.
• Identify factors that cause shifts in demand and supply for good and services.
• Describe how changes in supply and demand change equilibrium price and quantity.

Which of the following is INCORRECT regarding interest rates?

1. Describe what is known about the transmission of both Ebola and Coronavirus. You must include in this answer a discussion of the organism itself (i.e. is it a virus, bacteria- what makes it unique).

2. Describe the immune response (both humoral and cell-mediated) to Ebola and Coronavirus that typically occurs (please include a graphic depiction).

3. Discuss the difficulty in creating a vaccine for both Ebola and Coronavirus.

4. Discuss the cultural and lifestyle changes that can reduce transmission of both Ebola and Coronavirus and why these can be difficult to enact.

Three of the seven goals in the National Plan to Improve Health Literacy are:

• Goal 1: Develop and disseminate health and safety information that is accurate, accessible, and actionable
• Goal 2: Promote changes in the healthcare delivery system that improve information, communication, informed decision-making, and access to health services
• Goal 3: Incorporate accurate and standards-based health and developmentally appropriate health and science information and curricula into child care and education through the university level

Describe two different ways to fulfill those goals(each). Please be specific.

Consider two bonds with $1,000 face values that carry coupon rates of 5%, make annual coupon payments, and exhibit similar risk characteristics. The first bond has two years to maturity whereas the second has three years to maturity. The yield to maturity of these investments is 5%. If the yield to maturity rises by half a percentage point, what are the respective percentage price changes of the two bonds? Find the exact answer and approximate answers using the duration rule and the duration-convexity rule. Discuss the quality of the approximation.

Phil is a 42-year-old who has a ventricular arrhythmia and was prescribed a Class 1 antiarrhythmic to treat his condition. He has been taking the medication for a couple of years now and recently started to have pain in his joints and has developed a rash that has become bothersome. He is refilling his prescription at your pharmacy and mentions to you that he has noticed these changes.

What medication is Phil most likely taking, and what is happening to Phil?

What course of action should be taken?

A 32-year-old female patient was diagnosed with sickle cell anemia had complicated recurrent hospital admissions with vaso-occlusive crises and chest syndrome. Lab findings showed normochromic, normocytic mild to moderate anemia. Genetic investigations showed lysine was substituted for glutamine acid at position 6 on some chains and valine instead of glutamine at position 6 on other chains.  What anemia does she have and what are the two genetic (base to base changes) point mutations that cause her disease?

For each of the following, put "A" if it is always true, "S" if it is sometimes true, or "N" if it is never true.

(a) The net force on an object is zero if its speed remains constant.

(b) Normal force cannot do work on any system.

(c) If mechanical energy is not conserved, friction is the reason.

(d) A person riding a ferris wheel will feel heaviest at the bottom.

(e) If a moving object changes direction, a net force must act on it.

(f) The terminal velocity of a 25 kg object is higher than that of a 10 kg object.

2. Use the following information to prepare, in good form, an income statement, a statement of changes in equity, and a statement of financial position for Geelin Industries Ltd. for the month ended August 31, 2018:

...... Accounts payable..........................................................       $ 9,375

...... Accounts receivable......................................................           5,500

...... Bank loan payable.........................................................         13,750

...... Cash..............................................................................         58,750

...... Common shares............................................................         94,375

...... Dividends declared........................................................          6,250

...... Income tax expense......................................................         17,375

...... Insurance expense........................................................           2,125

...... Building..........................................................................       125,000

...... Retained earnings (beginning)......................................         40,625

...... Revenues......................................................................         78,750

...... Salaries expense...........................................................        20,625

...... Supplies.........................................................................           1,250