Please paraphrase the following passages:

1. “The process of adapting to new technologies is reflected in the changing metaphors we use to explain ourselves to ourselves. When the mechanical clock arrived, people began thinking of their brains as operating ‘like clockwork’. Today, in the age of software, we have come to think of them as operating ‘like computers’. But the changes, neuroscience tells us, go much deeper than the metaphor. Thanks to our brain’s plasticity, the adaptation occurs also at a biological level” (Carr 128).
2. “The aim of this book is to argue that Huxley was right, that the most significant threat posed by contemporary biotechnology is the possibility that it will alter human nature and thereby move us into a “posthuman” stage of history. This is important, I will argue, because human nature exists, is a meaningful concept, and has provided a stable continuity to our experience as a species” (Fukuyama 259).

Below are three possible investments that follow a 5-year time horizon:

1. Invest in a basic human resource information system:

• Cost: $300K
• Cash Flows: $150K each year for 5 years

2. Invest in a high-end human resource information system:

• Cost: $1 Million
• Cash Flows: $500K each year for 5 years

3. Invest in a talent acquisition function

• Cost: $500K
• Cash Flows: $250 K each year for 5 years.

Assume that you will pay for one of these projects by withdrawing funds from an account earning 8%. 1. Build a spreadsheet (e.g., using Google Sheets) that models the cash flows appropriately.

2. Calculate the NPV and IRR for each project.

3. Pick the project that you would fund and explain why you picked it.

Choose one of the following management theories below. They are all found in Chapter 2 of the Dunn (2016) textbook.

Industrial Revolution

One of the Classical School theories

Bureaucratic Management Theory

Human Relations Movement

Human Resources School

One of the Contemporary Management Theories

Write an essay and discuss the following: Briefly identify and discuss the theory. Include when the theory was popular in management, how it evolved, and the basic beliefs that the management theory followed or follows.

Research and find one scholarly article on the management theory you’ve chosen to discuss.

What additional information does your article tell you about the management theory you are discussing?

Using both the textbook and the article you found, discuss one element about the theory you are reviewing that might be helpful if you were managing a primary care office today.

Write 2-3 paragraphs, no more than a page in length, that answer the following:

1. Using your anatomical information, hypothesize about the evolutionary relationships of these four organisms (humans, rats, elephants, and dolphins). Describe traits that can group some of them together and traits that make each of them unique when compared to the others.
2. Which of the three non-human organisms do you think would be best suited for research on a drug that might help humans fight cancer? Explain your answer. (Note that you can take anatomical, physiological, and ethical considerations into account.)
3. Which of the three non-human organisms do you think would be best suited for research on mitochondrial disorders and their effect on ATP production? Explain your answer. (Same as above, you can take a variety of factors into account.)

1. Urban sprawl can have some negative impacts on the environment with respect to use of resources, land use, andpollution. Choose ONE of these three aspects and EXPLAIN why having large areas of suburbs rather than densely populated urban areas can have a negative environmental impact.

2. Advancements in agriculture have decreased the percentage of the human population that is malnourished, even as the human population has dramatically increased. However, this success has not been without a price.  CHOOSE TWOof the three advancements listed below, and fully EXPLAIN one way that this practice can negatively impact the ENVIRONMENT (not just humans). (Note: if you answer all three, please indicate which two you want to be graded. Otherwise I will grade the first two that are answered.)

Use of inorganic fertilizers

Use of pesticides

Use of transgenic crops

1. Historically, women were less likely to invest in a college degree than men. Why was this the case? What has changed to reverse this trend?

2. Explain the economics underlying the human capital investment decision (specifically, the decision to go to college versus sticking with just the high school diploma).

3. Empirical evidence shows clearly that, on average, individuals with more years of education earn more money, other things equal. Two different theories support this evidence: human capital theory and signaling theory. Explain both theories.

4. Describe the trends over time in (a) educational attainment by gender; and (b) percentage of graduates in selected professional degree programs that are female. Then provide reasons for the particular significance of the 1970s in these trends. 5. Describe the trend since 1974 in the college wage premium and the gender difference in this trend.

a)

The pulse rates of ten adult women were found to be as follows:

                    83    58  70  56  76  64  80  76  64  83

Assume that the pulse rate of women is normally distributed. At a 5% level of significance can you conclude that that the true pulse rate of women is less than 72?

B) The costs associated with conducting interviews for a job opening have skyrocketed over the years. According to a Harris interactive survey, 211 of 502 senior human resources executives at U.S companies believe that their hiring managers are interviewing too many people to find qualified candidates for the job. Suppose the true proportion of human resource executives who believe that their hiring managers are interviewing too many people is given by p. At a 5% level of significance can you conclude that the true proportion p differs from 40%?

We have four tubes containing individual primers that are designed to amplify two particular regions of the human genome.

While organizing tubes, we accidently erased all the information regarding these tubes. Use the following web tools to figure

out which primer is paired with which another to amplify which region of human genome.

(UCSC In-Silico PCR: http://genome.ucsc.edu/cgi-bin/hgPcr?hgsid=568061131_Us1GaoCaBcZKgNTGBAA8MZeDDOz3)

Primer 1: 5’-GTTTGGAGACAACGCTGGCC-3’

Primer 2: 5’-CTGCCCAGGGCCTCACCACCA-3’

Primer 3: 5’-ACATTTGCTTCTGACACAAC-3’

Primer 4: 5’-AATTGGAAGCAAATGACATC-3’

Once you find out the genomic regions, explain what size of each PCR product you will obtain if you actually do PCR?

Also, describe what kind regions of these two PCR products are coming from (such as intron or exon).

A 36-year-old female has a routine physical. She is single, doesn’t smoke and has a few drinks of alcohol a week. She began menarche at age 11 and her first sexual intercourse was at age 14. She has had numerous sexual partners and does not regularly use barrier contraception. Physical examination is normal. The Pap smear comes back as atypical squamous cells of undetermined significance (ASCUS).

a. What risk factors does she have for cervical cancer?

b. Describe the pathogenesis of Human Papilloma Virus.

c. Why should HPV testing be done and what are the tests to be ordered?

d. What HPV subtypes are associated with cervical cancer?

e. Explain the role of E6 and E7 HPV proteins in cervical cancer.

f. Differentiate between Human Papilloma Virus and Herpes Simplex virus

With regards to human cheek cells, how many copies of D1S80 do you theoretically add to a PCR tube and what precautions could be made to ensure only your own DNA was added to the PCR reaction?

How is creatinine produced in the body?

Why would urine creatinine levels be a good indicator of kidney function?

When assessing kidney function what other measurements are used?

Give TWO other examples where the concentration of a metabolite in urine is used diagnostically. In each case explain the context and the disease/disorder being diagnosed.

You need to prepare a standard curve at the same time as the unknown measurements. Why is this best practice?

What compounds may interfere with the measurement of creatinine in urine?

The normal range of creatinine concentration in human urine is 5-25 mM. What conditions would return an abnormal value?