Mary-Lou is a 75-year-old widow, who lost her husband to cancer over a year ago. Her family and friends have noticed that she has been very teary, has low self-esteem and has lost interest in the things she used to love such as going to bingo with her friends and gardening. Her family initially put this down to the loss of her husband and thought it would pass with time. However, they are now getting really concerned as they have noticed that her mood is not improving still. When asked by her daughter if she is sleeping well, she says she has been drinking wine every night to help her go to sleep. It makes her feel happy and relaxed. What started as one glass a night has now increased to two or three glasses a night, and she has also started drinking during the day. Her daughter has noticed that her mum’s face always appears flushed and that she has had quite a few colds lately. Mary-Lou is also losing her balance and experiencing mood swings. Her daughter is worried that she is relying too heavily on alcohol and fears that she is starting to get short-term memory loss from the alcohol consumption. She has been forgetting things such as where she put her keys, whether she turned on the washing machine, why she opened the fridge and forgetting the topic of conversation when talking with her daughter on the phone. Mary-Lou has also been getting disorientated and getting lost when she goes out on her daily walks. A neighbor rang her daughter one day to tell her that she found Mary-Lou wandering around aimlessly, and when questioned what she was doing Mary-Lou snapped and said she was trying to get home. Her daughter decided it was time to take Mary-Lou to the local GP to work out what was going on with her. After listening to the signs and symptoms Mary-Lou was experiencing, the GP diagnosed her with depression and prescribed 50 mg of Fluoxetine/Prozac daily. Based on the results of clinical and radiological assessments, the GP determined that she had early onset Alzheimer’s disease. He prescribed a cholinesterase inhibitor and gave them information on support groups and tips on what to do from here on in. He also prescribed 10 mg of Diazepam daily to help with the withdrawals from alcohol abuse.

Explain the mechanism of action of two drug types Mary-Lou is prescribed with and describe how these drug actions help mitigate some of her symptoms. In your answer, make references to the pathophysiology of the relevant diseases. Explain how these drug help to mitigate her symptoms.

Mary-Lou is a 75-year-old widow, who lost her husband to cancer over a year ago. Her family and friends have noticed that she has been very teary, has low self-esteem and has lost interest in the things she used to love such as going to bingo with her friends and gardening. Her family initially put this down to the loss of her husband and thought it would pass with time. However, they are now getting really concerned as they have noticed that her mood is not improving still. When asked by her daughter if she is sleeping well, she says she has been drinking wine every night to help her go to sleep. It makes her feel happy and relaxed. What started as one glass a night has now increased to two or three glasses a night, and she has also started drinking during the day. Her daughter has noticed that her mum’s face always appears flushed and that she has had quite a few colds lately. Mary-Lou is also losing her balance and experiencing mood swings. Her daughter is worried that she is relying too heavily on alcohol and fears that she is starting to get short-term memory loss from the alcohol consumption. She has been forgetting things such as where she put her keys, whether she turned on the washing machine, why she opened the fridge and forgetting the topic of conversation when talking with her daughter on the phone. Mary-Lou has also been getting disorientated and getting lost when she goes out on her daily walks. A neighbor rang her daughter one day to tell her that she found Mary-Lou wandering around aimlessly, and when questioned what she was doing Mary-Lou snapped and said she was trying to get home. Her daughter decided it was time to take Mary-Lou to the local GP to work out what was going on with her. After listening to the signs and symptoms Mary-Lou was experiencing, the GP diagnosed her with depression and prescribed 50 mg of Fluoxetine/Prozac daily. Based on the results of clinical and radiological assessments, the GP determined that she had early onset Alzheimer’s disease. He prescribed a cholinesterase inhibitor and gave them information on support groups and tips on what to do from here on in. He also prescribed 10 mg of Diazepam daily to help with the withdrawals from alcohol abuse.

Question 1 Based on the clinical picture presented above, you should have identified three diseases/conditions we have covered in BIOL122.

• Name two of the diseases/conditions you identified, and

• List two characteristic signs or symptoms (per disease) that you noted in Mary-Lou’s history

• Finally, explain the pathophysiology of both diseases/conditions you named (i.e., explain the changes that cause the disease and relate the typical signs and symptoms of the disease).

Question: I. On January 1, Year 2017, Kennard Co. issued $2,000,000, 5%, 10-year bonds, with interest payab...

I. On January 1, Year 2017, Kennard Co. issued $2,000,000, 5%, 10-year bonds, with interest payable on June 30 and December 31 when the market rate of interest for similar bonds was 6%. Use the following format and round figures to nearest dollar.

1. Actual proceeds received from the issuance of the bonds

2. Prepare an amortization schedule for Year 1 and Year 2 using the effective interest rate method.

Date    Cash Paid    Interest Expense Amortization    Bond Carry Value

3. Show how this bond would be reported on the balance sheet at December 31, Year 2.

Assume the following information:

1-year deposit rate offered on U.S. dollars    =          2.5%

1-year deposit rate offered on Singapore dollars       =          4.0%

1-year forward rate of Singapore dollars       =          $0.795

Spot rate of Singapore dollar =          $0.80

Given this information, does covered interest arbitrage worthwhile for a US investor? Assume the investor invests $1,000,000

Please do not round during intermediate steps and round your final answer to four decimal places.

please show work

Assume the following information:

1-year deposit rate offered on U.S. dollars    =          2.5%

1-year deposit rate offered on Singapore dollars       =          4.0%

1-year forward rate of Singapore dollars       =          $0.78

Spot rate of Singapore dollar =          $0.80

Given this information, does covered interest arbitrage worthwhile for a US investor? Assume the investor invests $1,000,000

(______)

Please do not round during intermediate steps and round your final answer to two decimal places.

College athletic departments are rarely self-sufficient, yet coaches’ salaries increase year-after-year. Explain why

    this is the case.

I. On January 1, Year 2017, Kennard Co. issued $2,000,000, 5%, 10-year bonds, with interest payable on June 30 and December 31 when the market rate of interest for similar bonds was 6%. Use the following format and round figures to nearest dollar.

1. Actual proceeds received from the issuance of the bonds

2. Prepare an amortization schedule for Year 1 and Year 2 using the effective interest rate method.

Date    Cash Paid    Interest Expense Amortization    Bond Carry Value

3. Show how this bond would be reported on the balance sheet at December 31, Year 2.

An 18-year-old man was admitted with multiple injuries after he and a passenger, another 18-year-old man, were in a motor vehicle accident. After receiving 50 mL of the first unit of blood, the patient developed shaking chills and became hypotensive. The unit of blood was immediately discontinued and the blood bank was asked to recheck the crossmatch STAT.

Laboratory Testing:

Clerical Check                          No evidence of blood bank clerical errors.

Hemoglobinemia                      Slight hemolysis observed

Pre-transfusion DAT                 Negative

Post-transfusion DAT               Weakly positive (mixed field)

Recheck of blood grouping

Recheck of Crossmatching       Patient pre-transfusion specimen and donor segment = compatible (IS)

                                               Patient post-transfusion specimen and donor segment = incompatible (IS)

Interpretation

What info do you gather from the test results and info given?

If 10-year T-bonds have a yield of 4.6%, 10-year corporate bonds yield 6.9%, the maturity risk premium on all 10-year bonds is 1.3%, and corporate bonds have a 0.15% liquidity premium versus a zero liquidity premium for T-bonds, what is the default risk premium on the corporate bond? (Express your answer as a percent and round your answer to two decimal places.)

5-year Treasury bonds yield 6.7%. The inflation premium (IP) is 2.13%, and the maturity risk premium (MRP) on 5-year T-bonds is 0.52%. There is no liquidity premium on these bonds. What is the real risk-free rate, r*? (Express your answer as a percent and round your answer to two decimal places)

Carla earns $100,000 per year now and pays $20,000 per year on her fixed-rate mortgage. Her income is subject to a COLA clause. If the risk-free rate of interest is 3%, and the expected inflation rate is 2% per year, what is the spending power of her net income in 10 years, expressed in today's dollars? And how would you find the present value of 10 years of Carla's income without being given an inflation rate or interest rate? HINT: Use market data to determine your answer.