Questions
These are the three most prominent ways that therapeutic agents are found: (1) a completely new...

These are the three most prominent ways that therapeutic agents are found:
(1) a completely new agent (the actual chemical structure) that binds to a known receptor, but elicits a
different patient outcome due to more selective binding, reduced adverse effects, etc.
(2) a new use for a known drug or agent – sometimes this is already used “off-label” or has colloquial
usage for this indication, but the specific mechanism has not been identified or clinical trials not run
(3) a new mechanism is one that has not been previously approved for that disease state – usually from a
reported case study, novel presentation/response, or years of dedicated research
Your will need to:
Identify a disease state that you would like to “treat”
Identify which of the above three you will attempt
Develop a strategy and fill in rationale/background for your design

In: Nursing

In the end, all the characters in Everything I Never Told You survive-- except Lydia. James...

In the end, all the characters in Everything I Never Told You survive-- except Lydia. James and Marilyn reconcile, emotionally and physically. Hannah begins to receive love and appreciation from her mother especially. Nath gets to punch out Jack, go to Harvard, and eventually (as one line of the novel reveals) becomes an astronaut. But Lydia dies. Why was she the family's fulcrum for suffering in the years leading up to, and why did she drown in the lake that night? Why did the author choose to have this family suffer the loss of the "favored" daughter, and the daughter to become the eternal victim? This is a fiction, after all, and the author could have chosen to let the character live. But would Lydia's survival been unbelievable? Was her death necessary for the others to survive psychologically and spiritually?

In: Nursing

2. You're a beta fish breeder and have noticed that you have a few fish that...

2. You're a beta fish breeder and have noticed that you have a few fish that display a totally novel ruby red coloring pattern. This ruby red color has since become is very popular in your Etsy store, but you are STRUGGLING to develop a purebreeding strain. Like, every time two ruby red betas are crossed, you end up with a fair number of ruby reds, but still a significant number of betas featuring the standard-type coloration. In your most recent ruby red x ruby red mating attempt, you ended up with 57 ruby red betas and 28 standard betas. All other such matings gave similar phenotypic offspring ratios. Explain what's going on here. (<4 sentences)

In: Biology

GMO labeling A genetically modified food is a food product developed from a different genetically modified...

GMO labeling

A genetically modified food is a food product developed from a different genetically modified organism (GMO) such as a crop plant, animal or microorganisms. The general principle of producing a GMO is to add novel genetic material into an organism's genome resulting in both new and useful traits. Some governments (like the entire EU, China and Japan) have emphasized risks over benefits from GM foods and require mandatory labeling and traceability, while others, such as the U.S., have no such requirements. Some want to know whether what they are eating are genetically modified organisms (GMOs) or not, they may be worried about their own health or the environment’s. Some argue that GMO labeling isn’t an effective way to change the food system, or even that it could cause unnecessary panic.

Contribute to the discussion with your thoughts about the GMO labeling.

In: Biology

Crime Control Model Define the assigned theory of punishment. Identify and describe an example of a...

Crime Control Model

  1. Define the assigned theory of punishment. Identify and describe an example of a movie, television show or novel that depicts this theory of punishment.
  2. Describe the prison system that was established under the assigned theory of punishment. What was the philosophical basis for this style of punishment (i.e., religion, political changes, science, etc.)? Identify the goals for the prison system. What types of activities were inmates assigned under this prison system? Did prisons gain revenue because of inmate productivity? How was this accomplished?
  3. Compare the either prison system reviewed to the Auburn (New York) or Pennsylvania Prison System. Describe the similarities and differences between the two systems.
  4. Assess the strengths and weaknesses of your assigned theory of punishment. Provide two weaknesses and two strengths for the theory of punishment and its prison system.

In: Operations Management

Cigarette packages and advertisements have included warning labels for several years, but the Family Smoking Prevention...

Cigarette packages and advertisements have included warning labels for several years, but the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act) signed into law in 2009 required that stronger and more graphic health warnings appear on cigarette packages by 2012. In 2011, the Food and Drug Administration proposed nine new textual warning statements that were much stronger than previous warning statements. The new warning statements included words such as “Cigarettes are addictive,” “Cigarettes cause cancer,” and “Tobacco smoke may harm your children.” These statements were to be accompanied by color graphics depicting the negative health effects of smoking. Some of the proposed graphics included a picture of diseased lungs, a man smoking with smoke coming out of a hole in his throat, decaying teeth and mouth cancer, a mother blowing smoke into her baby’s face, and dying people. The Tobacco Control Act dictated the placement of these statements and graphics on packages and advertisements, taking up at least 50 percent of the front of the package and at least 20 percent of the advertisement. Research reveals that the best way to quit is to reduce the intake of tobacco in small increments over time rather than attempting to quit it altogether.

In the Warning Labels Scenario, a proposed graphic includes a picture of a set of diseased and distorted human lungs that makes it difficult for consumers to immediately identify that the package contains cigarettes. However, with a little effort, most consumers will be able to identify the product. Which of the following reactions is most likely responsible for the customers’ cognitive categorization of the new packaging?

In the Warning Labels Scenario, many smokers will read the labels on the packs and process the image in the warning, but this will not bring about a change in behavior as they don’t believe that this will happen to them personally. This is an example of _____.

In the Warning Labels Scenario, many smokers will read the labels on the packs and process the image in the warning, but this will not bring about a change in behavior as they don’t believe that this will happen to them personally. This is an example of _____.

In Warning Labels Scenario, research reveals that the best way to quit smoking is to reduce the intake of tobacco in small increments over time, rather than to attempt quitting it at one go. This is an example of achieving desired behavior through _____.

In: Economics

please asnwer the following questions Chapter 13 Questions 1. What is patient abuse? (LLO #1) 2....

please asnwer the following questions

Chapter 13 Questions

1. What is patient abuse? (LLO #1)

2. Discuss common signs of abuse for both children and seniors. (LLO #1)

3.Describe what should a caregiver do when he or she suspects another unrelated person, caregiver, or family member has been abusing a patient. (LLO #1)

4. Discuss the importance of accurate and complete documentation of suspected abuse. (LLO #1)

5. Describe what good-faith reporting means. (LLO #1)

6. Discuss why patients are often reluctant to complain about their abusers and caregivers. (LLO #1)

7. When a health care provider reports abuse, should the accuser’s identity be revealed to the accused? Explain your answer. (LLO #1)

8. Should caregivers be disciplined for reporting abuse if it proves to be false? Explain your answer. (LLO #1)

9. Discuss the patient poem “Look Closer, See Me.” (LLO #1)

In: Nursing

"Durable press" cotton fabrics are treated to improve their recovery from wrinkles after washing. "Wrinkle recovery...

"Durable press" cotton fabrics are treated to improve their recovery from wrinkles after washing. "Wrinkle recovery angle" measures how well a fabric recovers from wrinkles. Higher is better. Here are data on the wrinkle recovery angle (in degrees) for a random sample of fabric specimens. Assume the populations are approximately normally distributed with unequal variances. A manufacturer believes that the mean wrinkle recovery angle for Hylite is better. A random sample of 25 Permafresh (group 1) and 20 Hylite (group 2) were measured. Test the claim using a 1% level of significance.

EXPLAIN ALL STEPS ON THE TI-84

Permafresh Hylite
148 137
128 139
156 143
118 132
117 140
154 145
135 143
129 145
136 134
151 145
128 134
114 143
125 134
157 135
122 146
163 137
146 139
126 138
90 141
131 139
120
135
133
146
146

H0: Select an answer μ σ² s² x̄₁ μ₁ x̄₂ μ₂ p  = Select an answer x̄₂ μ₂ p x̄₁ μ₁ s² μ σ²  
H1: Select an answer σ² p μ₂ s² μ₁ μ x̄₁ x̄₂  Select an answer = ≠ ≤ < > ≥  Select an answer μ s² μ₂ x̄₂ μ₁ p σ² x̄₁  

Select the correct symbols.

Test Statistic= Give answer to 4 decimal places.

p-value=

Give answer to 4 decimal places.

In: Statistics and Probability

1. "Durable press" cotton fabrics are treated to improve their recovery from wrinkles after washing. "Wrinkle...

1. "Durable press" cotton fabrics are treated to improve their recovery from wrinkles after washing. "Wrinkle recovery angle" measures how well a fabric recovers from wrinkles. Higher is better. Here are data on the wrinkle recovery angle (in degrees) for the same fabric specimens discussed in the previous exercise:

Permafresh 138 135 132 134 132
Hylite 141 144 147 139 145

The mean (±0.01) and the standard deviation (±0.0001) for the Permafresh are:   
x x¯ = s = .


The mean (±0.01) and the standard deviation (±0.0001) for the Hylite are:   
x¯¯¯x¯ = s = .


The standard error and the value of the t statistic are (±0.001):   
    SE =     t =


The P-value for this two sided test is (±0.01): ⩽P⩽

2.

Do women and men differ in how they perceive their life expectancy? A researcher asked a sample of men and women to indicate their life expectancy. This was compared with values from actuarial tables, and the relative percent difference was computed (perceived life expectancy minus life expectancy from actuarial tables was divided by life expectancy from actuarial tables and converted to a percent). Here are the relative percent differences for all men and women over the age of 70 in the sample:

Men -26 -24 -19 -20 -14 -12
Women -23 -17 -15 -12 -11 -7 -8


Use technology to approximate the t distribution for this test. Do NOT use the conservative approach.

The t test statistic (±±0.001) is

The degrees of freedom (±±0.001) of the t test statistic is

In: Statistics and Probability

Governor Cuomo's press conference he just announced that from a sample of 7,500 New Yorker's, 14.3%...

Governor Cuomo's press conference he just announced that from a sample of 7,500 New Yorker's, 14.3% tested positive for the Covid antibodies. (Note the presence of the antibodies indicates you have been infected with the virus.) The sample was taken in public places, for example at grocery stores, where individuals were asked if they would voluntarily be tested. I believe that the 14.3% infection rate woefully biased. Provide the reason and defined in the text and class notes and an explanation as to the mechanism that has led me to this belief.

In: Statistics and Probability