These are the three most prominent ways that therapeutic agents
are found:
(1) a completely new agent (the actual chemical structure) that
binds to a known receptor, but elicits a
different patient outcome due to more selective binding, reduced
adverse effects, etc.
(2) a new use for a known drug or agent – sometimes this is already
used “off-label” or has colloquial
usage for this indication, but the specific mechanism has not been
identified or clinical trials not run
(3) a new mechanism is one that has not been previously approved
for that disease state – usually from a
reported case study, novel presentation/response, or years of
dedicated research
Your will need to:
Identify a disease state that you would like to “treat”
Identify which of the above three you will attempt
Develop a strategy and fill in rationale/background for your
design
In: Nursing
In: Nursing
2. You're a beta fish breeder and have noticed that you have a few fish that display a totally novel ruby red coloring pattern. This ruby red color has since become is very popular in your Etsy store, but you are STRUGGLING to develop a purebreeding strain. Like, every time two ruby red betas are crossed, you end up with a fair number of ruby reds, but still a significant number of betas featuring the standard-type coloration. In your most recent ruby red x ruby red mating attempt, you ended up with 57 ruby red betas and 28 standard betas. All other such matings gave similar phenotypic offspring ratios. Explain what's going on here. (<4 sentences)
In: Biology
GMO labeling
A genetically modified food is a food product developed from a different genetically modified organism (GMO) such as a crop plant, animal or microorganisms. The general principle of producing a GMO is to add novel genetic material into an organism's genome resulting in both new and useful traits. Some governments (like the entire EU, China and Japan) have emphasized risks over benefits from GM foods and require mandatory labeling and traceability, while others, such as the U.S., have no such requirements. Some want to know whether what they are eating are genetically modified organisms (GMOs) or not, they may be worried about their own health or the environment’s. Some argue that GMO labeling isn’t an effective way to change the food system, or even that it could cause unnecessary panic.
Contribute to the discussion with your thoughts about the GMO labeling.
In: Biology
Crime Control Model
In: Operations Management
Cigarette packages and advertisements have included warning labels for several years, but the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act) signed into law in 2009 required that stronger and more graphic health warnings appear on cigarette packages by 2012. In 2011, the Food and Drug Administration proposed nine new textual warning statements that were much stronger than previous warning statements. The new warning statements included words such as “Cigarettes are addictive,” “Cigarettes cause cancer,” and “Tobacco smoke may harm your children.” These statements were to be accompanied by color graphics depicting the negative health effects of smoking. Some of the proposed graphics included a picture of diseased lungs, a man smoking with smoke coming out of a hole in his throat, decaying teeth and mouth cancer, a mother blowing smoke into her baby’s face, and dying people. The Tobacco Control Act dictated the placement of these statements and graphics on packages and advertisements, taking up at least 50 percent of the front of the package and at least 20 percent of the advertisement. Research reveals that the best way to quit is to reduce the intake of tobacco in small increments over time rather than attempting to quit it altogether.
In the Warning Labels Scenario, a proposed graphic includes a picture of a set of diseased and distorted human lungs that makes it difficult for consumers to immediately identify that the package contains cigarettes. However, with a little effort, most consumers will be able to identify the product. Which of the following reactions is most likely responsible for the customers’ cognitive categorization of the new packaging?
In the Warning Labels Scenario, many smokers will read the labels on the packs and process the image in the warning, but this will not bring about a change in behavior as they don’t believe that this will happen to them personally. This is an example of _____.
In the Warning Labels Scenario, many smokers will read the labels on the packs and process the image in the warning, but this will not bring about a change in behavior as they don’t believe that this will happen to them personally. This is an example of _____.
In Warning Labels Scenario, research reveals that the best way to quit smoking is to reduce the intake of tobacco in small increments over time, rather than to attempt quitting it at one go. This is an example of achieving desired behavior through _____.
In: Economics
please asnwer the following questions
Chapter 13 Questions
1. What is patient abuse? (LLO #1)
2. Discuss common signs of abuse for both children and seniors. (LLO #1)
3.Describe what should a caregiver do when he or she suspects another unrelated person, caregiver, or family member has been abusing a patient. (LLO #1)
4. Discuss the importance of accurate and complete documentation of suspected abuse. (LLO #1)
5. Describe what good-faith reporting means. (LLO #1)
6. Discuss why patients are often reluctant to complain about their abusers and caregivers. (LLO #1)
7. When a health care provider reports abuse, should the accuser’s identity be revealed to the accused? Explain your answer. (LLO #1)
8. Should caregivers be disciplined for reporting abuse if it proves to be false? Explain your answer. (LLO #1)
9. Discuss the patient poem “Look Closer, See Me.” (LLO #1)
In: Nursing
"Durable press" cotton fabrics are treated to improve their recovery from wrinkles after washing. "Wrinkle recovery angle" measures how well a fabric recovers from wrinkles. Higher is better. Here are data on the wrinkle recovery angle (in degrees) for a random sample of fabric specimens. Assume the populations are approximately normally distributed with unequal variances. A manufacturer believes that the mean wrinkle recovery angle for Hylite is better. A random sample of 25 Permafresh (group 1) and 20 Hylite (group 2) were measured. Test the claim using a 1% level of significance.
EXPLAIN ALL STEPS ON THE TI-84
| Permafresh | Hylite |
|---|---|
| 148 | 137 |
| 128 | 139 |
| 156 | 143 |
| 118 | 132 |
| 117 | 140 |
| 154 | 145 |
| 135 | 143 |
| 129 | 145 |
| 136 | 134 |
| 151 | 145 |
| 128 | 134 |
| 114 | 143 |
| 125 | 134 |
| 157 | 135 |
| 122 | 146 |
| 163 | 137 |
| 146 | 139 |
| 126 | 138 |
| 90 | 141 |
| 131 | 139 |
| 120 | |
| 135 | |
| 133 | |
| 146 | |
| 146 |
H0: Select an answer μ σ² s² x̄₁ μ₁ x̄₂ μ₂
p = Select an answer x̄₂ μ₂ p x̄₁ μ₁ s² μ
σ²
H1: Select an answer σ² p μ₂ s² μ₁ μ x̄₁
x̄₂ Select an answer = ≠ ≤ < > ≥ Select
an answer μ s² μ₂ x̄₂ μ₁ p σ² x̄₁
Select the correct symbols.
Test Statistic= Give answer to 4 decimal places.
p-value=
Give answer to 4 decimal places.
In: Statistics and Probability
1. "Durable press" cotton fabrics are treated to improve their recovery from wrinkles after washing. "Wrinkle recovery angle" measures how well a fabric recovers from wrinkles. Higher is better. Here are data on the wrinkle recovery angle (in degrees) for the same fabric specimens discussed in the previous exercise:
| Permafresh | 138 | 135 | 132 | 134 | 132 |
| Hylite | 141 | 144 | 147 | 139 | 145 |
The mean (±0.01) and the standard deviation (±0.0001) for the
Permafresh are:
x x¯ = s = .
The mean (±0.01) and the standard deviation (±0.0001) for the
Hylite are:
x¯¯¯x¯ = s = .
The standard error and the value of the t statistic are
(±0.001):
SE =
t =
The P-value for this two sided test is (±0.01): ⩽P⩽
2.
Do women and men differ in how they perceive their life expectancy? A researcher asked a sample of men and women to indicate their life expectancy. This was compared with values from actuarial tables, and the relative percent difference was computed (perceived life expectancy minus life expectancy from actuarial tables was divided by life expectancy from actuarial tables and converted to a percent). Here are the relative percent differences for all men and women over the age of 70 in the sample:
| Men | -26 | -24 | -19 | -20 | -14 | -12 | |
| Women | -23 | -17 | -15 | -12 | -11 | -7 | -8 |
Use technology to approximate the t distribution for this
test. Do NOT use the conservative approach.
The t test statistic (±±0.001) is
The degrees of freedom (±±0.001) of the t test statistic is
In: Statistics and Probability
In: Statistics and Probability