I have an issue understanding maternally and paternally imprinted gene questions.

Here are some examples:

1. A phenotypically normal man named John is heterozygous for a deletion on chromosome 15 that contains the maternally imprinted gene SNPRN gene. Absence of SNPRN gene function results in Prader-Willi syndrome. The man marries a normal woman named Jane who does not carry the deletion. They have 2 children. Which of the following statements is FALSE?

A. John inherited the chromosome with the deletion from his mother

B. There is a 25% chance that both children will have Prader-Willi syndrome

C. Half of John's sperm contain a version of the SNPRN gene that would be expressed in his children

D. All of Jane's eggs contain a version of the SNRPN gene that would be expressed in her children

E. in Jane's somatic cells, there is one active copy of the SNRPN gene.

The answer is D, but how are choices B and E true? I'm in a genetics course at a university so being detailed would be helpful please.

2. The Igf2 gene in mice encodes a growth factor gene whose expression is necessary for normal size. The absence of the Igf2 gene products results in small mice. The Igf2 gene is a maternally imprinted gene, meaning it gets inactivated during oogenesis in females. A normal-sized female mouse heterozygous for a deletion of the Igf2 gene gives birth to a normal-sized male. This male is then crossed to a normal female (no deletion). Assuming that this male inherits the Igf2 deletion from his mother, what fraction of the progeny from this male will be small?

A. 1/4 B.0 C.1/2 D.1/3 E.1

The answer is C, but again I don't understand why.

Quintiles Transnational: Dennis Gillings founded Quntiles Transnational in 1982 when he realized that drug companies were great at inventing new medicines but not particularly good at analyzing the vast amounts of data that came out of clinical trials. He thought drug testing should be broken down into a series of standardized steps and he signed up a network of doctors interesting in enrolling patients in clinical trials. In the ten years leading up to 2010, Quintiles had conducted 4,700 trials on 2.7 million patients.

Quintiles also established a large contract sales organization (CSO) to support its pharmaceutical company clients. Large pharmaceutical companies, faced with cost pressures as well as the costs of maintaining their own sales forces, have increasingly turned to CSOs like the Innovex division of Quintiles, PDI Inc., or inVentive Health to provide variable cost “flex reps” as an alternative to adding the fixed cost they would incur if they added to their own sales forces. CSOs are widely used in therapeutic areas that require somewhat less scientific knowledge, like respiratory, dermatology, and lifestyle. The growth rate in contract sales and marketing was projected at 35% to 2015.

Question:  What are the risks of using or not using the CSO arm of Quintiles. 150 words or more.

Kathy Lee Gifford is very popular in America.She decided to launch a clothesline for low-income families in America. Like other clothing businesses, she decided to seek an oversees business where she can get the garment made, while at the same time give jobs to citizens of a poor county.In her research, she discovered that she could have the clothes made the less costly in Thailand.She contacted her attorney who then entered into an agreement with a Thailand manufacturing company, who then negotiated with a local Thai garment employer to make the clothes. The employer then opened 10 sewing shops in various cities within Thailand to accommodate her monthly supply orders.

The agreement was faxed to the company and neither she, nor her attorney ever made a visit to the shops within the four years that they were in business.One day a reporter was tipped off that one of the sewing centers was a well-known sweatshop in the garment area where the workers were forced to work under unhealthy conditions (no air condition and leaky roofs) and had to work 14 long hours with only two breaks?As a matter of fact, it was later discovered that all of the shops were considered “sweatshops”.

1. Who are the affected stakeholders?

2. What should Kathy Lee do with this new revelation?(Remember that she

is under a contractual duty at this time).

3. Would you continue to wear clothes if you knew that they came from a sweatshop?

4. Why wasn’t this a “win-win” situation like Mrs. Lee thought it would be? ( Low costs clothes for low income people)

Suppose these are the following Demand/MV and Supply/MC equations for higher education, where Q is the number of students and P is tuition.
The marginal value equation is: MV=17.80-1.40*Q
The marginal cost equation is: MC=1.00+0.59*Q


13.What is the equilibrium tuition(price)?  

=5.98

Students receive a per-unit $2.00 scholarship if they attend university.

14. What is the new tuition?  

=6.57

15. What is the total amount spent on scholarships?  

Now, in addition to the scholarships received by students, the university receives a $1 per student subsidy.




16. What will the new tuition be?  


17. What is the total revenue (including subsidy) to universities?  

In a conversation with the dean of technology for the university, you have discovered that the university does not have a current disaster recovery and business continuity plan. Provide a 1-2-page document for the dean of technology that describes the elements to be considered for business continuity and disaster recovery. In your document, include the following: Why the business continuity and disaster recovery plan is necessary What should be considered and covered in a business continuity plan and disaster recovery plan Explanation of the major elements of disaster recovery and business continuity Discussion of different options for disaster recovery Describe how disaster recovery and business continuity are impacted by tools and best practices surrounding assurance of data accuracy and consistency

This financial option is offered by a university for its degree course that lasts exactly three years.

The students will repay in instalments after the end of the course. The instalments are determined as follows:

• No payments are made until three years after the end of the course.

• Over the following 15 years, students pay the university RM325 at the beginning of each quarter.

• After 15 years of payments, the quarterly instalments are increased to RM375 at the beginning of each quarter.

• After a further 15 years of payments, the quarterly instalments are increased to RM450 at the beginning of each quarter for a further 15-year period after which there are no more payments.

The rate of interest is at 3% per annum effective.

Calculate the present value.

The construction cost of a parking facility on a local university campus is $200,000. Assume that

maintenance will begin on the facility at the end of the third year of operation, and will increase by

$500/year until the end of the useful life of the facility. Maintenance costs are expected to accrue to

$2,000 during the third year of operation. If the interest rate is 7%, and the facility is expected to last

25 years, find the following (5 points):

a) The present worth of the maintenance costs of the facility (2 points)

b) The facility’s annual maintenance costs. (2 points)

c)

The university wants to charge an annual decal rate of $200/year. Is this a good economic

decision if there are 50 spaces in the parking facility? (1 point)

As part of its twenty-fifth reunion celebration, the Class of 1980 of State University mailed a questionnaire to its members. One of the questions asked the respondent to give his or her total income last year. Of the 820 members of the class of 1980, the university alumni office had addresses for 583. Of these, 421 returned the questionnaire. The reunion committee computed the mean income given in the responses and announced, ”The members of the class of 1980 have enjoyed resounding success. The average income of class members is $120,000!”. Identify two distinct sources of misleading information in this result, being explicit about the direction of the mistake you expect. Explain how you might fix each of these problems.

In C#

Start to develop a registration program for Continental University. At this stage of development, the program only needs to keep track of some basic information about a student, including first name, last name, and number of credits taking. You will gradually enhance the program in subsequent assignments. You need to implement a class named Student that represents a student, and a testing program. The testing program should prompt the user to enter the data about a student and then display a summary.

Sample Dialog

Welcome to the Continental University Registration System!

Enter data about a student

First Name: Tom

Last Name: Evans

Credits Taking: 12

Evans, Tom Credits Taking: 12

Bass Ltd, a leading producer of construction, mining and electrical equipment, suffered a significant drop in the demand of the company’s products due to COVID-19 in 2020 that significantly threatens the financial stability of the company. Bass in order to survive in this critical situation decides to restructure its strategy for forthcoming years. Changes in company strategies and accounting policies have a significant impact on reported profit. The basic earnings per share and diluted earnings per share presented in the company’s current year financial statements in accordance with “AASB 133 Earnings per Share” were comparatively higher than that of the last year. In contrast, company share prices have dropped by 20% at the reporting date, according to Yahoo finance.

While most shareholders seem unhappy to own company shares for the meagre dividend attached to them the question of whether Bass Ltd are fully valued at their current share prices continues to linger.

The directors of Bass Ltd are not sure how to calculate and include basic and diluted earnings per share in the company’s financial statements in accordance with AASB 133, and called for a report from the Finance Manager of the company.

On 30 June 2020, Bass Ltd had the following equity:

During the year ended 30 June 2020, the company earned after tax profit of $1 240 000 from ordinary activities.

The additional information is available.

1. On 20 November 2019, the company made a one-for-five bonus issue, and on 30 March 2020, the company made a rights issue of 400 000 ordinary shares.
2. On 20 July 2017, the company issued $ 750 000 of 8% convertible notes. Each $ 100 note was convertible into 50 ordinary shares. There was no conversion during the year ended 30 June 2020.
3. On 28 February 2019, the company issued options to purchase 10 000 shares at $ 3.50 each. No options were exercised during the year ended 30 June 2020.
4. The company income tax rate is $ 0.30 in the dollar and the company’s ordinary shares are trading at $ 5 per share on 30 June 2020.
5. The company paid preference dividends of $ 40 000.

Required

1. Briefly describe the requirements of AASB 133 ‘earnings per share’ for the calculation of earnings per share.