SARS-CoV2 is a coronavirus that infects the cells of the mammalian respiratory epithelium. To replicate it needs to take over the host cells secretory pathway to generate essential viral proteins. You are working to try and find a treatment for this virus. Answer all the following questions related to the virus and the secretory system:

a) You discover that the virus needs to insert a protein called ‘Spike’ into the plasma membrane for newly formed viral particles to be infectious. The RNA for Spike is in the cytosol. Describe briefly SIX key steps for how the Spike protein gets into the plasma membrane.

b) You determine the sequence of the Spike protein and identify the following amino acid sequence motifs. What is the function of each sequence (i) Asn–X–Ser/Thr (ii) A long stretch of hydrophobic residues near the centre of the sequence. (iii) Asp-X-Glu (Di-acidic sequence)

c) The Spike protein also contains a sequence you recognise as a cleavage site for an enzyme called Furin. You know Furin cleavages can activate other pro-proteins. What does this tell you about Spike?

d) To infect epithelial cells the SARS-CoV Spike protein binds to a receptor on the plasma membrane and is endocytosed. Describe THREE key steps that are essential in this process.

e) Reading back over Questions a-d, name a protein you could target in a treatment for COVID-19 and explain why you chose it.

PLEASE READ: This is one question with 3 parts to it, please answer the full question.

Mark M. Upp has just been fired as the university bookstore manager for setting prices too low (only 20 percent above suggest retail). He is considering opening a competing bookstore near the campus, and he has begun an analysis of the situation. There are two possible sites under consideration. One is relatively small, while the other is large. If he opens at Site 1 and demand is good, he will generate a profit of $ 200,000. If demand is low, he will lose $180,000. If he opens at Site 2 and demand is high, he will generate a profit of $100,000, but he will lose $20,000 if demand is low. He also has the option of not opening either. He believes that there is a 50 percent chance that demand will be high. Mark can purchase a market research study from Brooklyn College. The survey costs $10,000. The probability of a good demand given a favorable study is 0.8. The probability of a good demand given an unfavorable study is 0.3. There is a 45 percent chance that the study will be favorable. Draw a decision tree to determine the following:

a)What should Mark’s decisions be?

b)What is the maximum amount Mark should be willing to pay for this study?

c)What is the efficiency of the study?

Hint: The revised probabilities have already been calculated for you.

A 48-year-old woman comes to the clinic for a routine wellness checkup. In speaking with the nurse, the patient reports she has an intermittent aching feeling in her left lower abdomen and feels sluggish at times. She describes herself as a “couch potato” and says she gets a lot of exercise at her job and driving her sons to various activities. When the nurse palpates the abdominal area, the patient denies pain at the time but expresses that she is getting tired of feeling this ache and cannot explain why it is there. The patient is a busy mother of three boys and works from 7 am to 3 pm daily in a day care center near her home.

1. Identify the clinical problem(s) in the case study.
2. In speaking further with the patient, the nurse discovers that the patient does not eat breakfast because of her early work schedule and that she routinely eats a lunch consisting of a banana, diet soda, and pizza. The patient also reports her last bowel movement was 3 days ago, which is a change in her bowel habits. Based on all the information so far, what problem(s) should the nurse consider the patient may have?
3. After a thorough examination and testing, it is determined that the patient’s symptoms are due to constipation. Explain what education the nurse can provide to the patient to assist her in dealing with this problem.

A transparent cylindrical tube with radius r = 1.50 cm has a flat circular bottom and a top that is convex as seen from above, with radius of curvature of magnitude 2.60 cm. The cylinder is filled with quinoline, a colorless highly refractive liquid with index of refraction n = 1.627. Near the bottom of the tube, immersed in the liquid, is a luminescent LED display mounted on a platform whose height may be varied. The display is the letter A inside a circle that has a diameter of 1.05 cm. A real image of this display is formed at a height s′ above the top of the tube

The object in part B is moved sinusoidally according to s = Asin(ωt), where A is the amplitude and ω is the angular frequency. The frequency of the motion is 1.00 Hz. What is the velocity of the image when the object is at its midpoint and traveling upward? Express your answer with the appropriate units. Enter positive value if the deflection is upward and negative value if the deflection is downward.

( Part B question was

The luminescent object is moved up and down periodically so that the real image moves up and down in the air above the tube. A mist in the air renders this display visible and dramatic. If we want the image to move from 60.0 cmcm above the top of the cylinder to 1.00 mm above the top of the cylinder during this motion, what is the corresponding range of motion for the object distance ss? Find the minimum value of ss.

Express your answer with the appropriate units.)

1. If a CRT is designed so that the spot traverse the indicator face in 900µsec, what range could be indicated by a spot deflection half-way across the indicator?

2. Increasing the transmit power of a radar by a factor of 5 will increase the maximum range by what percent?

3. An observer at rest near the source of the sound of frequency 684Hz. Another source of sound 676Hz is moving toward the observer at 2m/s. If the speed of the sound waves in air is 340m/s, what is the beat frequency heard by the observer?

4. An ambulance moves at 72KPH while sounding a siren with a frequency of 1500Hz. Motorcyclists move at speed of 20m/s in opposite directions with ambulance. If the speed of sound in air is 340m/s, what is the ratio of frequencies heard by motorcyclists when approaching and away from the ambulance?

5. A fire truck emits an 880Hz siren. As the truck approaches an observer on the sidewalk, he perceives the pitch to be 950Hz. What pitch does he hear after the truck passes and moving away? Assume the truck’s velocity remains constant and the velocity of sound in air is 340m/s.

6. Two cars approach each other at 50m/s when one car starts to beep its horn at a frequency of 475Hz. What is the wavelength of the horn as heard by the other driver? Assume the speed of sound in air to be 343m/s.

Imagine you are a researcher for the Turonis Pizza Company interested in learning the effects of student population on quarterly sales. You collect sales data from a sample of 10 Turonis Pizza Parlor restaurants located near college campuses with known student populations. For the ith observation or restaurant in the sample, x is the size of the student population (in thousands) and y is the quarterly sales (in thousands of dollars). The values for x and y for the ten restaurants in the sample are summarized in the table located below:

Table: Student Population and Quarterly Sales Data for 10 Turonis Pizza Parlors

1. Create a scatter diagram of the data in the table above. Place student population on the horizontal axis and quarterly sales data on the vertical axis. What preliminary conclusions can be drawn from this scatter diagram?

2. BY HAND, calculate the simple regression equation that represents the relationship between quarterly sales and the student population. Then, predict the quarterly sales of a restaurant with a student population of 16,000.

Quarterly Sales (y) = b0 ± b1x (Student Population)

CORPORATE VALUATION

Brandtly Industries invests a large sum of money in R&D; as a result, it retains and reinvests all of its earnings. In other words, Brandtly does not pay any dividends, and it has no plans to pay dividends in the near future. A major pension fund is interested in purchasing Brandtly's stock. The pension fund manager has estimated Brandtly's free cash flows for the next 4 years as follows: $2 million, $5 million, $9 million, and $16 million. After the fourth year, free cash flow is projected to grow at a constant 3%. Brandtly's WACC is 12%, the market value of its debt and preferred stock totals $62 million; and it has 14 million shares of common stock outstanding.

Write out your answers completely. For example, 13 million should be entered as 13,000,000.

1. What is the present value of the free cash flows projected during the next 4 years? Round your answer to the nearest cent. Do not round your intermediate calculations.
   
   $
2. 
   
3. What is the firm's horizon, or continuing, value? Round your answer to the nearest cent.
   
   $
4. 
   
5. What is the firm's total value today? Round your answer to the nearest cent. Do not round your intermediate calculations.
   
   $
6. 
   
7. What is an estimate of Brandtly's price per share? Round your answer to the nearest cent. Do not round your intermediate calculations.

An Excel spreadsheet using formulas and cell referencing is required for this assignment.

Careen owns a condominium near Hershey, PA that she rents out part of the year. This year, she incurs the following expenses in connection with her rental condo:

  
During the year, Careen rented the condo for 112 days, receiving $17,600 of gross income. She personally used the condo for 49 days. Assuming Careen uses the court method of allocating expenses to rental use of the property.

She files single and in addition to expenses listed above, she paid the following amounts:

Remember that for itemized deductions (from AGI) the deduction for state taxes is limited to $10,000.

Determine how much depreciation she is allowed to deduct. Then determine her net rental income (loss), her total amount of “for AGI” deductions, and her total amount of itemized deductions (from AGI). Include and fill in the following table within your Excel worksheet:

1. Scenario analysis

1. You are leading a role of Chief Financial Officer of a Cement Company in Oman. Your company has huge current profit of RO 10 million and presently having a plan to capital investment of RO 8 million in the next financial year. The company is willing to continue capital structure of debt 25% and Equity 75% in the future. How much of the RO 10 million should your company pay out as dividends? And what would be the dividend payout ratio of your company?
2. In case you retain huge amount of profit of your company for long term investment, what financial decision do you take – to pay high cash dividend? Or to issue bonus share (stock dividend)? And explain why?
3. Presently, your company’s Face Value of Equity Share RO 10 and Market Value of your Share in MSM is RO 25 per share. In order to increase the trading volume and market liquidity of your company stock, will you suggest the management to go for stock split? Explain your management about concept of stock slip with the advantage of splitting the stock of your company with the current scenario.
4. Given the current scenario COVID 19 and its impact on Cement sector in the near future, what are the factors that you consider affecting the dividend policy of your company? Critically evaluate and justify.  

A. BNSF Railway operates dual-track intermodal routes between major ports and cities, like two lanes on a highway.

B. Designing a bluetooth system for a phone that is too fast for the latest model.

C. Despite thousands of designs and materials, eyeglasses are basically a frame with two folding arms that go over each ear, and a pair of lenses.

D. The car dealer has 100 cars on the lot. 3000 more are in teh distribution center near the ship channel, and a virtually limitless capacity is available from the factory in Europe.

E. UPS Readies Freezer Farms to Store Virus Vaccine When Approved

F. My phone has a battery but I carry an external rechargeable one for long trips.  

G. If you assume people vote loyally to their chosen political party, then straight ticket voting allows you to select your party's candidate for every office in an election with a single click.

H. A car at stage 12 at the assembly plant is having its tires installed while the seats are placed in another vehicle in stage 11.

match with 8 great ideas in computer architecture

• 1. Design for Moore's law
• 2. Use abstraction to simplify design
• 3. Make the common case fast
• 4. Performance via parallelism
• 5. Performance via pipelining
• 6. Performance via prediction
• 7. Hierarchy of memories
• 8. Dependability via redundancy