Bushy syndrome (BuS), sometimes referred as Amsterdam dwarfism, is a a rare human disease caused by a dominant loss of function mutation in any one of at least five different genes, all of which encode components or regulators of the cohesin protein complex. People with BuS have a wide range of morphological abnormalities, including growth retardation, mental impairment and sterility. Analysis of BuS patients shows that in addition to chromosomal mis-segregation during cell division, their abnormal phenotype may be likely due to widespread Mia-regulation of gene expression during development. Cohesin May play a role in organizing the chromatin loops necessary for proper regulation of transcription.
A) in different families, BuS can show an autosomal dominant or x-linked dominant inheritance pattern. How is this possible? What is this an example of?
B) explain how a loss of function allele in a gene encoding the cohesin protein could be dominant to the wild type allele.
C) BuS is usually caused by new mutation in one parents genome. Why?
D) explain the general function of the cohesin complex in eukaryotic chromosomes.
E) what is the role of shugosin?

An archaeologist measures the concentration of nitrogen (g/100 g of bone) in 41 human skeletons that have been interred for varying numbers of years. He is interested in how nitrogen concentration varies depending on length of interment. The data are available in the file nitro.csv.

If you have access to Jupyter R Notebooks please show work there!

a. Give the equation of the fitted regression line.

b. Create a plot of nitrogen concentration vs. length of interment, including the fitted regression line.

c. Interpret the slope of the fitted regression line in the language of the problem.

d. State the R2 value and its interpretation (in the language of the problem).

e. The archaeologist finds an additional skeleton that was interred for 80 years. What is the best prediction of its nitrogen concentration?

file:

"Intern.Time","Nitrogen"

88.5,3.6
85.2,3.53
71.8,3.7
70.6,3.82
68,3.58
71.6,3.61
70.2,4.01
55.5,3.74
36.5,3.98
36.3,3.86
46.5,3.88
35.9,3.95
45.5,4.11
43,3.77
44.9,3.82
59.5,3.79
58.3,3.74
56.5,3.93
56.3,3.78
43,4.01
42.5,4.17
29,3.82
35.3,4.11
93.6,3.52
90,3.63
88,3.84
84.4,3.69
84,3.55
79.7,3.53
67.4,3.67
64.7,3.74
64.7,3.62
38.3,3.79
59.6,3.82
32,4.02
32.2,4.05
26.5,4.01
34.7,3.76
27.6,3.87
35.7,3.82
49.6,3.65

To keep the calculations fairly simple, but still reasonable, we shall model a human leg that is 92.0 cm long (measured from the hip joint) by assuming that the upper leg and the lower leg (which includes the foot) have equal lengths and that each of them is uniform. For a 70.0 kg person, the mass of the upper leg would be 8.60 kg , while that of the lower leg (including the foot) would be 5.30 kg . Take that x-axis is directed horizontally and the y-axis is directed vertically downward.

A) Find the x-coordinate of the center of mass of this leg, relative to the hip joint, if it is stretched out horizontally.

B) Find the y-coordinate of the center of mass of this leg, relative to the hip joint, if it is stretched out horizontally.

C) Find the x-coordinate of the center of mass of this leg, relative to the hip joint, if it is bent at the knee to form a right angle with the upper leg remaining horizontal.

D) Find the y-coordinate of the center of mass of this leg, relative to the hip joint, if it is bent at the knee to form a right angle with the upper leg remaining horizontal.

Sophie Ball, the Director of Human Resources of your Northern Expeditions company, has advised that the company will be opening an office in Nunavut this year. The office will offer guided northern trips to hunters and adventurers. It expects to mainly employ local guides (40 days over the summer period) but the company will also be periodically bringing in guides from its offices in Alberta, Saskatchewan and Québec. Some of the guides from outside Nunavut may work 10 days, others could work 15 days over the summer depending on the number of bookings; they normally work in their home province for 60 days every year. The average daily rate paid to these guides is $400.

Sophie is asking for information on the Nunavut Payroll Tax. Who pays the tax and how is it calculated? Are there any special considerations or challenges for the calculation of the payroll tax for the guides brought in from Alberta, Saskatchewan and Québec? What are the reporting and remitting requirements during the year? What are the reporting requirements at year-end? Provide examples based on the information provided in the assignment to clarify.

Q1. The Human Development Index ( HDI) ...

Group of answer choices

-All options are correct

-is a summary measure of life expectancy, education, and per capita income indicators.

-was created to emphasize that GDP per capita is a good proxy for wellbeing.

-is a summary measure of income and inequality.

Q2. Using the relative poverty line we can compare the evolution of poverty across countries over time.

Group of answer choices

True

False

Q3. Country X has a population of 22 million. The last estimates available indicate that 4 million people spend less than $ 1.9 (US dollars) per day and 9 million spend less than $ 5 (US dollars) per day.

What is the Poverty Headcount Ratio of country X? This is a number from 0 to 1 and you should use two decimal points.

Q4.

Low-income countries tend to have lower fertility rates than high-income countries because the cost of raising a child is higher in low-income countries.

Group of answer choices

True

False

Q5

When looking at the evolution of GDP per capita across countries over time we notice some interesting patterns. What is true in terms of global development after WWII?

Group of answer choices

-There is a divergence of income among all countries

-Convergence of income among high-income countries

-Convergence of income among all countries

-Convergence of income among low and middle-income countries

Q6.

Health product subsidies (such as subsidized bed nets) are a type of household intervention.

Group of answer choices

True

False

Please help.

A Deloitte employment survey asked a sample of human resource executives how their company planned to change its workforce over the next 12 months. A categorical response variable showed three options: the company plans to hire and add to the number of employees, the company plans no change in the number of employees, or the company plans to lay off and reduce the number of employees. Another categorical variable indicated if the company was private or public. Sample data for 180 companies are summarized as follows.

1) Conduct a test of independence to determine if the employment plan for the next 12 months is independent of the type of company.

-State the null and alternative hypotheses.

-Find the value of the test statistic.

-Find the p-value.

2) At a 0.05 level of significance, what is your conclusion?

A)Reject H₀. We conclude that the employment plan is independent of the type of company.

b)Do not reject H₀. We cannot conclude that the employment plan and the type of company are not independent.   

c) Reject H₀. We conclude that the employment plan is not independent of the type of company.

d)Do not reject H₀. We cannot conclude that the employment plan and the type of company are independent.

3)Discuss any differences in the employment plans for private and public companies over the next 12 months. (Round your numeric answers to two decimal places.

A)Employment opportunities look to be about the same for both public and private companies, with high proportions of "no change" and "lay off employees" planned for both.

b)Employment opportunities look to be about the same for both public and private companies, with high proportions of "add employees" planned for both.    

c)Employment opportunities look to be much better for private companies, while public companies have the greater proportions of "no change" and "lay off employees" planned.

d)Employment opportunities look to be much better for public companies, while private companies have the greater proportions of "no change" and "lay off employees" planned.

You studied a small, isolated human population and identified a new gene A. You found these numbers of individuals with these genotypes (capital letter represents dominance): 250 individuals of AA genotype, 500 individuals of Aa phenotypes and only 1 aa genotype, who is a 3 years old boy. Is gene A in Hardy-Weinberg equilibrium? Describe the possible reasons why gene A is (or isn’t) at HardWeinberg equilibrium. What can you conclude from the collected data?

Human Resources department at a manufacturing company is concerned about unauthorized absences of its employees. As a part of their research, they decided to investigate the relationship between the number of unauthorized days that employees are absent per year and the distance (miles) between home and work for the employees. A sample of 10 employees was chosen, and the following data were collected. Perform an appropriate analysis on the data at a 0.01 level of significance. Answer the following questions in the boxes below. Problem 1a) State clearly what the independent and dependent variables are in the problem. Problem 1b) Develop a scatter diagram. Based on the scatter diagram developed, do you expect a relationship between the variables? Indicate the expected relationship type if any. Problem 1c) Write down the estimated regression equation (use variable names along with coefficients and not just x and y).

The human body contains about 10^(14) cells, and the diameter of a typical cell is about 10 micrometers. Like all ordinary matter, cells are made of atoms; a typical atomic diameter is 0.1 nanometers. I have all of the correct answers, but I do not know how to get to these answers or solve them on my own. I would like to get explanations (why?) and see how it should be done (math being done). a) How does the number of atoms in a cell compare with the number of cells in the body? The answer is "should be the same". b) The volume of the cell is about The answer is 10^(-15) m^3. c) The mass of the cell is about The answer is 10^(-12) kg. d) The number of atoms in the body is closest to The answer is 10^(30). Thanks.

In 1783, the French physicist Jacques Charles supervised and took part in the first human flight in a hydrogen balloon. Such balloons rely on the low density of hydrogen relative to air for their buoyancy. In Charles’s balloon ascent, the hydrogen was produced (together with iron(II) sulfate) from the reaction of aqueous sulfuric acid on iron filings. (a) Write a balanced chemical equation for this reaction. (b) What volume of hydrogen is produced at 300 K and a pressure of 1.0 atm when 300 kg sulfuric acid is consumed in this reaction? (c) What would be the radius of a spherical balloon filled by the gas in part (b)?