You are a researcher at a small biotech company and your company has just obtained the license for use of a human GENOMIC DNA fragment putatively encoding a potentially novel protein, which is thought to regulate p53, the known tumor supressor protein. The scientists who originally cloned this GENE fragment HDM5 "claim" that HDM5 shares 90% DNA sequence homology with one of the HDM2 genes (refer to the review Levine & Oren, 2009). They propose that HDM5 may have HDM2-like properties and may be involved in regulating cell proliferation, and thus a good target to potentially develop as a cancer therapy. Your company has asked you to characterize the gene and gene products, as well as to provide an opinion as to its potential human therapeutic uses.

1. Before proceeding, you wish to know whether this gene is actually expressed in humans ?Describe, in detail, 2 efficient experimental approaches to answer this question. ?Discuss whether your proposed methods measure synthesis or accumulation of the product

1. In the article “The human Vomeronasal Organ. Part II: Prenatal Development” (Journal of Anatomy, Vol.197, Issue 3, pp 421 -436), T. Smith and K. Bhatnagar examined the controversial issue of the human vomeronasal organ, regarding its structure, function, and identity. The following table shows the age of fetuses (x) in weeks and the length of crown-rump (y), in millimeters.

   x	10	10	13	13	18	19	19	23	25	28
   y	66	66	108	106	161	166	177	228	235	280

2. Give a point estimate of length of crown-rump in millimeter of an 18 weeks old fetus. Is this value the same as the observe value? What is the difference?

3. Find the 95% confidence interval for y when x = 18 (t.95= 2.05)

3. Calculate a 99% confidence interval of the slope of the actual population regression line (x-variable coefficient

Edit: Forgot to mark X and Y, apologies

True/false/ambiguous. For each of the following, indicate whether the statement is true, false, or ambiguous, and briefly explain your answer. If your answer depends on any assumptions, state them clearly. Use graphs or equations to illustrate your answer whenever it is helpful.

11. In efficiency wage models, employers take the market wage as given, and then choose the level of effort at which employees are required to work.

12. Mandatory retirement only makes sense in a delayed compensation (or underpayment-overpayment) model of earnings

13. In negotiating a salary with your employer, you should always try to get the highest salary possible – that is, the salary just below the level at which the employer would choose not to hire you. Otherwise you are leaving money on the table.

14. Workers are willing to invest in increasing their specific human capital as long as they capture all the economic returns to that investment.

15. If the economic return to school is due to signaling rather than human capital investment, then the private return to schooling is higher than the social return.

Which of the following terms best describes large patterns of normal cultural or social behavior, as well as laws and policy, that reinforce a given behavior within individuals?

Antonio is in the habit of eating chips and cookies and other snacks after dinner while watching TV. Recently he has begun to try to change this habit by instead either going for a walk or a run after dinner, or lifting simple hand weights and using exercise bands for strength building in front of the TV at night. Which process of change is Antonio engaging in?

What is NOT true of Ecological Models of Health Behavior?

The question can be answered in a variety of ways. You are encouraged (and in some case required) to use graphs and diagrams as part of your answer, to illustrate your argument or particular concept. This question requires a discussion of vertebrate cardiovascular system other than human.

The vertebrate cardiovascular (CV) system has a job of delivering a variety of molecules, entrained in plasma, to all the cells in your body. How does it achieve this function effectively (at sufficient rate) and efficiently (with minimal energetic cost)? How does the transport & transfer function differ in extant endotherms and ectotherms? Among vertebrates there's a wealth of circulatory designs, each of which must perform the transport/transfer function. Human CV system is similar only to that of other mammals (and birds, to some extent), but why would you leave out other vertebrates? How do their CV systems work? How good are they at transport? What are the constraints in different CV systems? So much to write about... This discussion should involve different cardiovascular systems.

You are a wireless communication specialist working with an ambitious exploratory firm named PROJECT-SPACE. The firm is embarking on a huge project to build a human habitat in planet Mars. In 25 years, PROJECT-SPACE projected that the human habitat will gradually evolved into a small space city with the population of 1000 occupants. The initial habitat should be able to accommodate 15 Martians with consistent, stable and reliable communication from Mars to the planet Earth command center back in the capital of the country.

1) How Internet, data rate, noise and bandwidth be sufficient to achieve stable and reliable communication from Mars to S.I. for 10 people and able to scale up to 1000 people in the future?
2) How Martian atmospheric effect reacts to wireless signals?
3) How do you panned to power up your wireless access-points and communication device?
4) What would be the time difference, latency (delay) in communication based on your proposed data rate and bandwidth?

Current position of the organisation: Provide an outline of goals and the philosophy of the organisation. Present the current target market and performance of the organisation.
2. Analysis of the business environment: Effectively assess the Micro-Environment, Market / Task environment and Macro-Environment of your organisation.
3. Roles and skills of managers: To discuss the overlapping roles of managers and the skills required of them in order to take the organisation. The management style of the management team and its relevance to the achievement of the organisational goals.   
4. Human Resources: An assessment of the organisations human resources in terms of skills, motivation and retention.   
5. Change Management: Ways in which management can react to the changing business environment. Discuss the inter-related approaches which the organisation can adopt in reacting to the environment.   
6. Organisation Design: The fundamental principles underlying organisation design should be discussed. Evaluate the organisational structure of the organisation and its suitability for the growth and expansion of the organisation
7. Recommendations: Present possible recommendations and critical success factors that the organisation should implement to achieve the desired goals.   

International Codes:

•The best starting point in the further development of standards for international business is self-regulation by business within the guidelines and standards that already exist.

•The UN Global Compact with business was proposed by the UN secretary-general in January 1999.

•The Compact challenges business to work with other companies, UN agencies, and nongovernmental organizations (NGOs) to support and implement ten basic principles stated in the Compact.

• The basic principles deal with respecting human rights, labor standards, protecting the environment, and eliminating corruption.

•

•The ILO is a specialized agency of the UN that has set up principles governing labor standards.

•The Caux Principles were launched in 1995.

•These principles emerged from a series of dialogues among a group of European, Japanese, and American firms.

•The principles are rooted in two basic principles:

–the Japanese principle of kyosei (working together for the common good); and

–the Western notion of the dignity and value of each human person as an end and not simply as a means to be used by others.

THE QUESTION IS : Talk more about it and the role of multinational corporations with giving examples .

1) Anatomically modern humans first reached North and South America by crossing _____________.

1. Northwest passage

2. Beringia

3. The Pacific

4. The Atlantic

2) According to the multi-regional model of human evolution, humans most likely evolved from

1. whatever species of hominid was found in each region; gene flow kept the populations linked

2. Neandertal populations in Europe and Asia.

3. a single population of Homo heidelbergensis somewhere in East Africa

4. populations of Homo erectus spread all across the old world with gene flow between them

3) How are Mousterian tools different from Acheulean and Oldowan tools?

1. Mousterian tools are larger than Acheulean and Oldowan tools

2. Acheulean and Oldowan tools are unifaced (one-sided) while Mousterian tools are bifaced

3. Mousterian tools were made by anatomically modern humans while Acheulean and Oldowan tools were made by Neandertals

4. Mousterian tools have only been found in North America, while Acheulean and Oldowan tools have only been found in Europe, Asia, and Africa

5. To make a Mousterian tool, one must strike the tool from the stone core

4) Neandertal skulls can be differentiated from Homo sapiens skulls

1. by the larger supraorbital torus of Homo sapiens

2. by the presence of an occipital bun and lack of a chin.

3. by the smaller brains of Neandertals.

4. because only Homo sapiens are found in Europe.

5) The Out-of-Africa Model of human origins:

1. Argues for replacement of existing populations by modern humans

2. Claims that Neandertals did not contribute genetic material to the human lineage

3. All of these

4. Suggests that humans had a single, localized origin