Suppose that a firm is considering moving from a batch process to an assembly-line process to better meet evolving market needs. What concerns might the following functions have about this proposed process change: Marketing, finance, human resources, accounting, and information systems?

            You are about to set up a new automobile repair business.

            Explain:

a.         What are all the essential functions of the human resource department of automobile repair business

            b.       What is a performance evaluation/appraisal?

c.         Explain the advantages and disadvantages of a performance appraisal/evaluation to the employee.

The bacterium Helicobacter pylori colonizes the stomachs of > 50% of the world's population. This species is what some call a "pathobiont," an organism that is a member of the human microbiome but can cause disease in some individuals. Of those infected with H. pylori, approximately 5% develop gastric ulcers and 1-3% develop gastric cancer. Interestingly, hosts that are colonized with H. pylori are also less likely to develop allergic diseases and active tuberculosis!

The high rate of gastric cancer and H. pylori recurrence after treatment in Tibet has led some administrators to propose treating the entire population of Tibet with antibiotics to eradicate the bacterium.

But is the proposed treatment a good idea from a public health perspective?

Discuss the benefits and problems that would result from such a country-wide treatment plan. Your discussion should take into account the functions and activities of the human microbiome that were presented in the reading."

A research associate working for Intragene Therapeutics prepares an investigative PCR reaction to screen human tissue samples for specific mutations. He uses 55 ng of genomic DNA from one tissue sample in a single PCR reaction, to amplify a 1,246 bp fragment. The PCR protocol requires a final concentration for two primers of 1.5 uM each, and a final concentration of 180 uM for dNTPs, in a total PCR reaction volume of 65 uL. During the PCR process, the fragment is amplified for 33 cycles. He quantifies the amount of PCR products to be 74 ng/uL.

3. How many copies of the fragment are produced in his PCR reaction? Assume that the target sequence is present in only one copy in the genome, as in a haploid human genome. Answer to the nearest whole number. Please show all work.

CORRECT ANSWER IS 16,667 COPIES OF TARGET SEQUENCE.

2. How many human genome equivalents are in 20 ng of cfDNA?

3. Investors have poured over 1 billion dollars into a company called “Grail” that promises ultra-sensitive early detection of cancer from one drop of blood. We routinely extract 20 ng/of cfDNA from 4 mLs of plasma. Assume one drop of blood has 40 ul of plasma. How many human genomes worth of cfDNA are in this one drop? Are claims they can detect one cancer genome among 10,000 normal cfDNA genomes well-founded?

4. Our qPCR standard is at 0.1 ng/uL. For the first qPCR standard dilution, we take 10uL of the qPCR standard and add it to 90uL TT buffer. How is this equivalent to 5000 GEs? (Note: the qPCR standard is a dilution of our LPA)

This is a metaphysics question: Sartre argues against supernatural or otherworldly religious beliefs. For Sartre, there are only two givens: nature, and radical human freedom. The categories of being are well-defined, and the problem of the human condition is clear.

      Lucretius, too, argues against traditional religious belief. For Lucretius, we are given nature, and we are given the abilities to observe and reason and feel. Here, again, the problem is clearly defined.

      Both Sartre and Lucretius argue for a truth that is grounded in something other than gods and spirits. What should we say about Plato, then? Is he a naturalist, or a supernaturalist, or something else altogether? What would Plato’s response to Lucretius or Sartre be?

You need to have a thesis (stake a claim)--the more interesting, the better.

     You need to argue in favor of that claim.

     You need to provide evidential support for that argument.

Let N be the number of requests to a web server per day and let N Poisson(). Each request

comes from a human with probability p or from a spam bot with probability 1 ? p. Assume that

the requests are independent of each other. Let X be the number of requests from humans per

day and Y be the number of requests from spam bots per day.

(a) State the conditional distribution of X given N = n, and state the conditional distribution of

Y given N = n.

(b) Calculate the probability of getting exactly x human requests and y spam requests.

(c) Find the joint probability mass function of X and Y , and show that X and Y are independent

of each other.

(d) Using your result in part (c), compute E[X + Y ] and Var[X + Y ].

What causes the welfare trap under traditional welfare arrangements?

a. Low income people cannot afford to acquire human capital

b. the break even income is too high to be reached

c. there are no jobs available in low income areas.

d. as earned market income increases, welfare benefits are withdrawn.

Which of the following statemets is true (correct)?

a. derived demand for labor depends on the demand for the prodct labor produces.

b. unions can either increase deamnd for, or decrease supply of labor.

c. Investment in human capital is expected to increase the demand for those workers

d. all of the above.

Which of the following statements is correct?

a. the distribution of wealth is not the best measure of true inequality

b. inequality using annual income overstates actual lifetime inequality

c. the inequality of annual incomes is less than the inequality of income

d. all the above are correct

Please paraphrase the following passages:

1. “The process of adapting to new technologies is reflected in the changing metaphors we use to explain ourselves to ourselves. When the mechanical clock arrived, people began thinking of their brains as operating ‘like clockwork’. Today, in the age of software, we have come to think of them as operating ‘like computers’. But the changes, neuroscience tells us, go much deeper than the metaphor. Thanks to our brain’s plasticity, the adaptation occurs also at a biological level” (Carr 128).
2. “The aim of this book is to argue that Huxley was right, that the most significant threat posed by contemporary biotechnology is the possibility that it will alter human nature and thereby move us into a “posthuman” stage of history. This is important, I will argue, because human nature exists, is a meaningful concept, and has provided a stable continuity to our experience as a species” (Fukuyama 259).

Below are three possible investments that follow a 5-year time horizon:

1. Invest in a basic human resource information system:

• Cost: $300K
• Cash Flows: $150K each year for 5 years

2. Invest in a high-end human resource information system:

• Cost: $1 Million
• Cash Flows: $500K each year for 5 years

3. Invest in a talent acquisition function

• Cost: $500K
• Cash Flows: $250 K each year for 5 years.

Assume that you will pay for one of these projects by withdrawing funds from an account earning 8%. 1. Build a spreadsheet (e.g., using Google Sheets) that models the cash flows appropriately.

2. Calculate the NPV and IRR for each project.

3. Pick the project that you would fund and explain why you picked it.