Which of the following alterations would likely contribute to the formation of a cancerous somatic cell? Fill in all correct answers if there are more than one.

A.Mutations in cyclin-dependent kinase genes that made the catalytic activity of the kinases cyclin-independent.

B.A mutation that inactivated expression of the gene that encoded the protein that de-phosphorylated the RB protein

C.A mutation in the p53 transcription factor binding site near the Bax gene promoter that eliminated p53 binding.

D.A mutation in the Mdm2 gene that eliminated the ability of the MDM2 protein to bind to p53.

E.A mutation in the Retinoblastoma (Rb) gene that eliminated the phosphorylation site on the RB protein.

F.A mutation in the Ras gene that eliminated the GTPase activity of the RAS protein.

G.A mutation in the Ras gene that generated a RAS protein that would not release bound GDP.

H.Mutations in the p53 gene that eliminated the sites of phosphorylation and acetylation on the p53 protein.

Consider N massless non-interacting spin-s fermions in a three-dimensional box of volume V .
(a) Find the Fermi energy E_F as a function of N, V , and s.
(b) For zero temperature, find the pressure in terms of N, V , and E_F .
(c) Plot the occupation of states as a function of the energy at a temperature of T =E_F /(10k). Your graph can be a sketch by hand. However, the effect of the finite temperature should be indicated clearly.
(d) Suppose that you start with a gas of these particles in a box of volume V near T = 0.
Now suppose that a valve is opened such that the gas can undergo a free expansion, allowing it to come to equilibrium at a new volume that is twice as large as the initial volume. Assuming no work or heat transfer occurs during the expansion, does the temperature of the gas go up, down, or stay the same? Explain your reasoning.

---You are advising the small town of Blackrock regarding future plans for 1,000 acres of forest located near the town. The owner of the forest has offered to sell the land to the town for $2,000,000. The forest provides many recreational benefits for local residents, as well as being the home of much wildlife including an endangered species. After conducting several studies you estimate that the annual recreational and environmental benefits will be $100,000 per year.

Using a discount rate of 1% explain your answer for following questions a) and b), and support your answers with appropriate calculations either using a spreadsheet (e.g. Excel) or via formulas please. Thank you!

a) Considering only the next 50 years, is buying the forest a good idea for the town? Why or why not?

b) What is the maximum amount the town would be willing to pay the landowner to lease the land for 50 years? Explain why.

for the past three years, the financial sector of Ghana has experienced some form of reinventions. these forms were so comprehensive that , the insurance subsector was not ignored. leveraging on technology, the oversight agency has streamlined insurance premium for all insurance companies. this implies that, the costs of premium have been standardized to nib in the bud the idea of an entity charging below or above the approved rate. this move it is understood will give law enforcement agencies like the police an easy way to check on the validly of motor insurance using the platforms provided by TELCOS on a USSD code. experts have argued that the move is in the right direction and that the only way insurance companies can increase their customer base is by rendering a near impeccable service to the public. as a student of finance, discuss the key shortcomings that may render the desire to offer quality services to the public by these insurance companies an impossibility.

the answers should be in essay form

Accrued Product Warranty

Lachgar Industries disclosed estimated product warranty payable for comparative years as follows:

( in millions)
Year 2 Year 1
Current estimated product warranty payable $12,333 $11,824
Noncurrent estimated product warranty payable 7,501 6,611
Total $19,834 $18,435

Presume that Lachgar’s sales were $160,705 million in Year 2. Assume that the total paid on warranty claims during Year 2 was $12,714 million.

a. The distinction between short- and long-term liabilities is important to creditors in order to accurately evaluate the near-term cash demands  on the business relative to the quick current assets and other longer-term demands .

Feedback

Review the need for a classified balance sheet.

b. Provide the journal entry for the Year 2 product warranty expense.

Product Warranty Expense
Product Warranty Payable

The figure below shows an end view of a solenoid along its axis. The solenoid has a circular cross section with a radius of r = 3.00 cm. It consists of 110 turns of wire and is 25.0 cm long. Inside the solenoid, near its center and coaxial with it, is a single loop of wire in the shape of a square, with each side of length ℓ = 1.00 cm. (The plane of the square loop is perpendicular to the solenoid axis.) A square with sides of length ℓ is completely inside of and concentric with a circle of radius r.

(a) Initially, there is a steady current of 2.00 A through the solenoid. What is the magnitude of the magnetic flux (in T · m2) through the square loop?  T · m2

(b) The current in the solenoid is then reduced from its initial value to zero within 2.50 s. What is the magnitude of the average induced emf (in V) in the square loop during this time?

1. In 1995, Betty White received a star on the Hollywood Walk of Fame – and her star is right near the star of her late husband, Allen Ludden. There are many couples that both have stars on the Hollywood Walk of Fame. This led Betty to wonder – is there a difference in the age between the husband and wife when they get their Hollywood star? As a result, Betty took a random sample of heterosexual couples that both have stars on the Hollywood Walk of Fame and recorded the age at which they received their star, given below.

At the .05 level of significance, is there evidence that there is a difference in the ages when husbands and wives get their Hollywood Walk of Fame star?

Suppose you are the manager of a public utility that supplies electricity to a significant portion of your geographic region. You preside over electrical generation facilities that can produce electricity using either natural gas or oil, or some combination of both. In the past several years, you have been faced with skyrocketing, then plummeting, natural gas prices, and now think you face the possibility of more of the same, coupled with the probability of similar volatility in oil prices. Having been trained in Managerial Economics, you are familiar with production functions, isoquant and isocost analysis, and other tools of microeconomics. How can you use these tools to decide the best path for your company to pursue? What are the pros and cons of using these tools? Provide specific examples of how to go about making the difficult decisions you must make in the near future as well as an overall blueprint of action.

1. Assess the following claims as either “True”, “False” or “Uncertain” and briefly explain your response:

(a.) “Assuming that the expectations theory of the term structure is true, if the market believes that interest rates are likely to decrease in the near future borrowers would immediately increase their supply of shortterm securities.”

(b.) “Assume you have a collection of municipal bonds and corporate bonds of similar maturities and default risk (i.e. both sets of bonds carry a rating of “AA+” from Standard and Poor’s). Accordingly, a yield curve formed from municipal bonds will be higher than a yield curve formed from the corporate bonds because of their tax-advantaged status.”

2. explain: (i.) The primary difference between the expectations theory of the term structure and the liquidity theory of the term structure, and (ii.) Why forward rates are biased predictors of future short rates if the liquidity theory holds.

Schedule of Cash Receipts

Rosita Flores owns Rosita's Mexican Restaurant in Tempe, Arizona. Rosita's is an affordable restaurant near campus and several hotels. Rosita accepts cash and checks. Checks are deposited immediately. The bank charges $0.60 per check; the amount per check averages $90. “Bad” checks that Rosita cannot collect make up 2 percent of check revenue.

During a typical month, Rosita's has sales of $46,000. About 80 percent are cash sales. Estimated sales for the next three months are as follows:

Required:

Prepare a schedule of cash receipts for May and June. Round your intermediate computations and final answers to the nearest whole dollar.