AFR Manufacturing Company’s senior management asked the internal audit function to conduct an operational safety audit of the production facility’s metal drill press unit. More specifically, the internal audit function was asked to determine how well the metal drill press equipment and equipment operators comply with company safety policies. Five downtime injuries of drill press operators occurred in the last six months. The total downtime for the five injuries was 37 hours. Management estimated that the drill press downtime, and the resultant decrease in overall productivity, reduced revenue by approximately $265,000. In addition to the downtime injuries, two drill press operators experienced detectible hearing loss during the six-month period. The internal auditors learned that the company’s safety policies include the following: ■ Operators are required to wear safety glasses, ear plugs, and protective gloves. ■ The drill presses are required to have a clear, plastic safety shield and a protected channel to safely feed the metal through the press. ■ The drill is operated by a knee switch. The operator engages and disengages the drill by shifting his or her right knee. The internal auditors found the equipment to be in relatively poor condition with little evidence of any regular maintenance. Drill bits were not replaced as they became dull, and broken bits often were used because new bits were not kept in supply. Two of the 10 drill press machines were missing safety shields. Five of the 10 machine operators were using the protective ear plugs at the time the auditors visited the plant and six were wearing safety glasses. Four of the knee switches were found to be sticking occasionally in both the off and on positions. The auditors perceived a general sense of negligence—negligence by production management, drill press equipment operators, and maintenance employees. 1.State the internal audit engagement purpose and objective. 2. Documents 2 internal audit observations that include all 4 attributes - condition, criteria, consequence(s) and cause(s). 3.Indicates 2 areas where internal audit might provide consulting assistance in response to the audit findings.

Please provide R code along with explanations for the following exercise:

Mortality rates per 100,000 from male suicides for a number of age groups and a number of countries are given in the data suicides2 (R package “HSAUR2”). Use appropriate graphical methods to comment on what the graphic tells us about the data.

When would using an image be unnecessary? Give an example. answer should be in complete sentences and  200--500 words long.

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When would you use graphic organizers (such as maps, charts, lists, or graphs) in your writing? Give an example. answer should be in complete sentences and  200--500 words long.

Given a sample of 90 couples, each couple having two children

What is the probability of any couple having one girl and one boy?

(4) The sample space that describes all three-child families according to the genders of the children with respect to birth order is In the experiment of selecting a three-child family at random, compute each of the following probabilities, assuming all outcomes are equally likely.
S = {bbb, bbg, bgb, bgg, gbb, gbg, ggb, ggg}
a. The probability that the family has at least two boys.
b. The probability that the family has at least two boys, given that not all of the children are girls.
c. The probability that at least one child is a boy.
d. The probability that at least one child is a boy, given that the first born is a girl.

A 7-year-old boy with an infected wound on his leg is admitted to the emergency department. His mother states that a high fever with diarrhea occurred during the last 12 hours. Within the last 2 hours he had become very lethargic, was unable to stand, and was very disoriented. The doctor observes that his blood pressure is dangerously low and suspects that the boy is suffering from bacterial septic shock caused by the wound infection.

Discuss the role of cytokines in the pathogenesis of this disease. Speculate on future therapeutic strategies that might be employed by using monoclonal antibodies or other biologic agents to treat this disease.

-Use implicit differentiation to find dy/dx where x²y² + x cos(y) = 6

-Use logarithmic differentiation to find the derivative of o(x) = (cos(x))^ln(x)

-Find the first and second derivatives of p(x) = 6 ln(x²+3x)

-A balloon is rising vertically at a constant speed of 5 ft/sec. A boy is

cycling along a straight road at a speed of 15 ft/sec. When he passes

under the balloon, it is 45 ft above him.How fast is the distance between

the boy and the balloon increasing 3 seconds later?

A snooker club can be used by players of both sex i.e. male and female, but not both at the same time. If a boy is in the club, other boys may enter, but any girl wishing to play snooker should wait until all boys leave and club become empty. Similarly, if a girl is in the club, other girls may enter, but any boy wishing to play should wait till the club becomes empty. Implement a solution to this problem using SEMAPHORES. At maximum only 6 boys or 6 girls can enter the club and play snooker as there are only 3 tables available in the club.

NEEDS TO BE DONE IN EXCEL WITH CALCULATIONS.

MakeNu mortgage company is offering a new mortgage instrument called the stable mortgage. This mortgage is composed of both a fixed rate and an adjustable rate component. Mrs. Maria Perez is interested in in financing a property, which costs 100,000 and is to be financed by Stable Home Mortgages( SHM) on the following terms:
a. The SHM requires a 5 percent down payment, costs the borrower 2 discount points, and allows 75 percent of the mortgage to be fixed and 25 percent to be adjustable. The fixed portion of the loan is for 30 years at an annual interest rate of 10.5 percent. Having neither an interest rate nor payment cap, the adjustable portion is also for 30 years with the following terms.

Initial interest rate = 9 percent

Index= one year treasuries

Payments reset each year

Margin= 2 percent

Interest rate cap= none

Payment cap= none

The projected one year U.S. Treasury bill index to which the ARM is tied, is as follows:
(BOY) 2= 10 percent; (BOY) 3= 11 percent; (BOY) 4= 8 percent; (BOY) 5 = 12 Percent
Calculate Mrs. Perez's total monthly payments and end of year loan balances for the first five years. Calculate the lenders yield, assuming Mrs. Perez repays the loan after five years.
b. Repeat part (a) under the assumption that the initial interest rate is 9.5 percent and there is an annual interest rate cap of 1 percent.

A mother brings her three-year-old son into the emergency room of a local hospital. The boy is crying hysterically. The mother says that earlier that day the boy was playing in the back yard with his older sisters. He had gone over to pick a rose off of a rosebush when he suddenly started screaming and crying. There is a region of swelling and redness on his arm and the doctor who examines him says that it looks like the boy was stung by a bee. On physical examination, he is afebrile, with a heart rate of 102 bpm, blood pressure of 90/62 mm Hg, and respiratory rate of 24 breaths per minute and has difficulty breathing. The doctor says that the boy appears to be having a severe allergic reaction to the sting, and he treats him with SC Epinephrine. The mother asks why her son’s arm is swollen and the Dr. says it is because of fluid accumulation.

1. Describe the process of inflammation that might have led to swelling? 2. Enumerate the mediators of pain, edema, and redness? 3. Describe the vascular and cellular changes during inflammation? 4. Mention the type of shock the child is presented with and Why epinephrine is an ideal choice in this setting and elaborate its mechanism of action? 5. Plot the Drug response curve (DRC) of Epinephrine (Agonist) with and without the presence of Beta-blocker (antagonist). 6. What type of hypersensitivity reaction is seen in this child? This type of hypersensitivity reaction is due to the crosslinking of which immunoglobulin on mast cell surfaces? 7. Which cytokines promote class switching of B lymphocytes to IgE?