Mention at least 3 significant changes that came about with the discovery or manipulation of fire.

Changes - what was the change "cooking"

Description - explain how it was manifested, "how it was done"

Reflection - how do you think this changed humanity in general

List and describe the changes that emerged after the discovery and mastery of the use of fire.

Q1.

(a) What should molecular properties of a small molecule drug be such that its ADME parameters
transports it efficiently across the blood brain barrier? Give examples of the drugs that have these
structural properties (e.g. active transporters)

(b) Use principles of molecular modeling and drug
design to explain the mechanisms of how enzymes evolve new functions.

(c) How is the Buckingham
potential a more realistic one compared to the Lennard Jones potential in modeling VDW interactions
in proteins and nucleic acids? Write out the potential energy expression using the Buckingham
potential. Define and explain its adjustable parameters.

(d) How would you combine a MC and a MD
algorithm to perform a molecular simulation on a biological system.

Q2.

(a) What are the differences between an energy based ligand design method such as GRID and a
knowledge based one like LUDI? What are the requirements of a knowledge based ligand design
method?

(b) Interpret the following QSAR equation: log (1/C)=k 1 ?-k 2 ? 2 + k 3 ?. How are factorial design
methods using in QSAR compound selection? Briefly outline how multiple linear regression analysis is
used in the derivation of a QSAR equation. How is cross-validation used for checking the quality of a
regression based QSAR model?

Q3.

(a) Use the example of molecular docking of the antibiotic netropsin to DNA to distinguish
quantitatively the differences between steepest descent and conjugate gradient methods for initial
refinement and stringent minimization. What qualitative conclusions can be drawn about the efficacy
of these two minimization techniques with respect to this docking experiment?

(b) Using two
examples, explain the thermodynamic differences between the Molecular Dynamics and Monte Carlo
methods. What are the advantages to choosing periodic boundary conditions in ANY molecular
simulation of a macromolecule? Use a diagram to plot 4 such periodic cell shapes. What important
class of applied molecular simulations have benefitted from the usage of periodic boundary
conditions?

Sharpe Middle School is applying for a grant that will be used to add fitness equipment to the gym. The principal surveyed 16 anonymous students to determine how many minutes a day the students spend exercising. The results from the 16 anonymous students are shown.

0 minutes; 40 minutes; 60 minutes; 30 minutes; 60 minutes; 10 minutes; 45 minutes; 30 minutes; 300 minutes; 90 minutes; 30 minutes; 120 minutes; 60 minutes; 60 minutes; 0 minutes; 20 minutes

** Lp = (p/100) (n + 1) (the p-th percentile formula to get the location).

Determine the following five values.

Min =

Q1 =

Med =

Q3 =

Max =

If you were the principal, would you be justified in purchasing new fitness equipment?  

ANSWER:

Is/are there any potential outlier (s)?

IQR=Q3-Q1=………………………………

Lower Limit: Q1 - 1.5(IQR) =……-…………..

Upper Limit: Q3 + 1.5(IQR)=……………..

Calculating the Arithmetic Mean of Grouped Frequency Tables

When only grouped data is available, you do not know the individual data values (we only know intervals and interval frequencies); therefore, you cannot compute an exact mean for the data set. What we must do is estimate the actual mean by calculating the mean of a frequency table. A frequency table is a data representation in which grouped data is displayed along with the corresponding frequencies. To calculate the mean from a grouped frequency table we can apply the basic definition of mean: mean = data sum/number of data values.

We simply need to modify the definition to fit within the restrictions of a frequency table.

Since we do not know the individual data values we can instead find the midpoint of each interval.  

The midpoint is = (lower boundary + upper boundary)/2.

We can now modify the mean definition to be  

                   Mean of Frequency Table = Σ f m/Σ f

where f = the frequency of the interval and m = the midpoint of the interval.

Karlene is the new managerial accountant at the Bay Beach House Restaurant. Karlene complies with principles and standards that help accountants deal with ethical challenges that she can encounter in the workplace. The principles and standards ensure that management accountants exhibit the highest level of ethical behavior. The four ethical standards include​ competence, confidentiality,​ integrity, and credibility. Which of the following requires management accountants comply with the four ethical​ standards?

A. Certified Management Accountant​ (CMA)

B. The Federal Reserve Board

C. ​IMA's Statement on Ethical Professional Practice

D. Certified Public Accountant​ (CPA)

E. Sarbanesminus−Oxley Act of 2002

Over a 17-year period researchers studied a sample of 707 individuals from a single community. They recorded the number of hours each individual spent watching television during adolescence and early adulthood. in later years, they recorded the number of aggressive acts by individuals in the study. Science magazine published the results in 2002 in an article titled "Television Viewing and Aggressive Behavior during Adolescence and Adulthood."

Pick the best description of this study:

A. an observational study to make an estimate or a claim about a population

B. an experiment to establish a cause-and-effect relationship between two variables

C. an observational study of an association between two variables

Pizza and the Subway The “pizza connection” is the principle that that the price of a slice of pizza in New York City is always about the same as the subway fare. Use the data listed below to determine whether there is a significant linear correlation between the cost of a slice of pizza and the subway fare.

Special purpose entities (SPE) were a factor in Enron’s accounting scandal. Read “The Rise and Fall of Enron” for more background information. Consider that FASB rules at that time only required 3% of the SPE to be held by investors outside of the company. Consider the pros and cons of following the FASB rules. Was Enron in violation of these rules? If not, what was the concern for SPE in Enron’s consolidated financial statements. Be sure to cite ASC codification if utilized in your discussion. USE YOUR OWN WORDS

see like below to find FASB rules

http://www.fasb.org/news/nr070102.shtml

THE RISE AND FALL OF ERON

https://www.journalofaccountancy.com/issues/2002/apr/theriseandfallofenron.html

Suppose that a typical urban consumer purchases a consumption bundle (CPI Basket) which includes 50 units of books, 100 units of clothes, 200 units of apples, and 300 units of pizza. The following table shows the unit price of each item in various years.

Please answer the following questions;

1. Calculate the cost of CPI basket.
2. Choose a base year
3. Calculate Consumer Price Index (CPI)
4. Calculate inflation rate.

The riskless rate for this period is 3.5%, and the covariance between returns on IBM stock and the S&P500 over this period is 0.02276.

1E. What is the variance of the S&P500 over this period?

1F. What is IBM’s CAPM beta according to this data?

1G. What is IBM’s CAPM cost of equity according to this data?

1H. If IBM’s debt to equity ratio is 0.57, what is their unlevered cost of equity according to this model?

Please show work for each.