1)List the B-cell developmental stages from pre-pro to immature B cells describing B-cell receptor (BCR or Ig) rearrangements occurring and/or key events occurring at each stage.

2)What is the role of Artemis in V(D)J recombination and why is it important?

3)During B-cell activation some activated B-cells undergo differentiation into antibody secreting plasma cells outside of the germinal center and therefore never go through the germinal center responses. Other activated B-cells will return to the follicle forming a germinal center and undergo processes that alter the antibody that will be produced.  Describe the germinal center responses. Why are these responses important (hint: what is different about the antibody produced)? Why are T cells important in germinal center responses?

Analyze its operations management activities of Coca Cola company

A written report must include the following

A i. Reasons choosing Coca cola company ( explain at least three reasons + supporting details)

A ii. Current financial status of the Coca Cola company

A iii. Number of workers

A iv. The competitors

A v. The suppliers

A vi. List of Coca Cola Company Product

A vii. Descriptions of Operations System – inputs, conversion process, output and the control   system (i.e. what are the actions taken if something happens unexpectedly?) of the company. Provide a sketch/diagram of the layout. From your viewpoint as a customer, what do you think of the layout? + supporting details (cite and quote references)

A viii. Suggestions

Provide any recommendations for the improvement + supporting details (cite and quote references).

Place the following list of scenarios in order from greatest energy required to least energy required, and explain using physics why you chose that order: i) A charge +q is brought in from ∞ to a distance r from a conducting sphere holding charge +Q; ii) A charge +q is brought in from ∞ to a distance r/2 from a conducting sphere holding charge +Q; iii) A charge +q is brought in from ∞ to a distance r from a conducting sphere holding charge +2Q; iv) A charge +q is brought in from ∞ to a distance r from a conducting sphere holding charge −Q; v) A charge +q is brought in from ∞ to an equidistance r from a conducting sphere of charge +Q and another sphere of charge −Q.

Holiday meals from different traditions include seafood, ham, beef, vegetarian, turkey, or other fowl and various side dishes. A survey of US families revealed that 58% of all families eat turkey at holiday meals ("T"), 42% eat vegetarian dishes ("V"), and 19% have both turkey and vegetarian dishes to eat at holiday meals. A family is selected at random. (Drawing shaded Venn diagrams may help determine the probabilities in the questions.)

a) What is the probability that the selected family had vegetarian dishes or a turkey?

b)What is the probability that the selected family had neither vegetarian dishes nor turkey?

c)What is the probability that the selected family had turkey but no vegetarian dishes?

d)"Families having turkey are disjoint from the families having vegetarian dishes." This statement is:

-True because P(T and V) ? -P(T)×P(V)
- False because P(T and V) ? P(T)×P(V)
-True because P(T and V) ? 0
-False because P(T and V) ? 0

A math department gives all college algebra students a test to test rather or not students taking college algebra on site perform better on Final than students that take class completely online. The Math department gathers random samples of 40 on-site students (Students who take class in the classroom) and 35 online students. The test score for each student in the random sample is determined. The mean score for the on-site students is 75, with a standard deviation of 12. The mean score for the online students is 72, with a standard deviation of 15.

Suppose a hypothesis test is conducted at the 5% significance level to determine if the mean score for all on-site students is higher than the mean score for all online students. Calculate the p-value associated with this hypothesis test. Round to 3 decimal places.

A math department gives all college algebra students a test to test rather or not students taking college algebra on site perform better on a test than students that take class completely online. The Math department gathers random samples of 40 on-site students (Students who take class in the classroom) and 35 online students. The test score for each student in the random sample is determined. The mean score for the on-site students is 75, with a standard deviation of 12. The mean score for the online students is 72, with a standard deviation of 15.

Suppose a hypothesis test is conducted at the 5% significance level to determine if the mean score for all on-site students is higher than the mean score for all online students. Based on the p-value, which of the following would be the best conclusion.

a. Since the p value is more than the level of significance, there is enough evidence to conclude that the average for ALL onsite students taking the test is equal to the average of all online students taking the test.

b. Since the p value is less than the level of significance, there is not enough evidence to conclude that the average for ALL onsite students taking the test is greater than the average of all online students taking the test.

c. Since the p value is more than the level of significance, there is not enough evidence to conclude that the average for ALL onsite students taking the test is greater than the average of all online students taking the test.

d. Since the p value is less than the level of significance, there is enough evidence to conclude that the average for ALL onsite students taking the test is greater than the average of all online students taking the test.

e. Since the p value is more than the level of significance, there is enough evidence to conclude that the average for ALL onsite students taking the test is greater than the average of all online students taking the test.

THREES ELECTRONICS COMPANY Threes Electronics is a mid-sized electronics manufacturer located in Santa Monica, California. The company president is Jack Tripper, who inherited the company. The company originally repaired radios and other household appliances when it was founded over 70 years ago. Over the years, the company has expanded, and it is now a reputable manufacturer of various specialty electronic items. One of the major revenue-producing items manufactured by Threes Electronic is a Personal Digital Assistant (PDA). Threes Electronics currently has one PDA model on the market and sales have been excellent. The PDA is a unique item in that it comes in a variety of tropical colors and is preprogrammed to play Jimmy Buffet music. However, as with any electronic item, technology changes rapidly, and the current PDA has limited features in comparison with newer models. Threes Electronic spent $750,000 to develop a prototype for a new PDA that has all the features of the existing one, but adds new features such as cell phone capability. The company has spent a further $200,000 for a marketing study to determine the expected sales figures for the new PDA. Threes Electronic can manufacture the new PDA for $86 each in variable costs. Fixed costs for the operation are estimated to run $3 million per year. The estimated sales volume is 70,000, 80,000, 100,000, 85,000, and 75,000 per each year for the next five years, respectively. The unit price of the new PDA will be $250. The necessary equipment can be purchased for $15 million and will be depreciated on a 7-year MACRS schedule. It is believed the value of the equipment in five years will be $3 million. Net working capital for the PDAs will be 20 percent of sales and will occur with the timing of the cash flows for the year (i.e., there is a no initial outlay for NWC). Changes in NWC will thus first occur in Year 1 with the first year’s sales. Threes Electronic has a 35 percent (federal & state) corporate tax rate. Threes Electronic plans to finance by a combination of 1/3 debt and 2/3 internal equity (i.e., retained earnings). The beta of the firm’s stock is 1.75. The firm uses a risk-free rate of 4% and the market risk premium of 7%. Threes has 15,000 9 percent semi-annual coupon bonds outstanding, $1,000 par value per bond, 15 years to maturity, selling for 108 percent of par. Threes Electronic can issue bonds for $5 ~ $6 million in the similar terms. Construct a project cash flow statement; estimate the cost of capital; and provide NPV, IRR, payback period (our target PB is 3 years) and profitability index of this project.

The mean number of students who went to examinations is 450 students with a standard deviation of 75 students. The distribution of the number of students is normal.

1. What number of students who correspond to the last 15%.
2. Fin the probability that less than 430 students want on campus examinations.
3. Calculate the probability that more than 400 students wanted on campus examinations
4. Determine the probability that between 452 and 463 students wanted on campus examinations

PUT DIAGRAMS PLEASE

Determine whether the given vectors are orthogonal, parallel, or neither.

32.

(a) u = (-5, 4, -2), v = (3, 4, -1)

(b) u = 9i-6j+3k, v = -6i+4j-2k

(c) u = (c, c, c), v = (c, 0, -c)

Use the Chain Rule to find the indicated partial derivatives. N = p + q p + r , p = u + vw, q = v + uw, r = w + uv; ∂N ∂u , ∂N ∂v , ∂N ∂w when u = 4, v = 2, w = 8

77 kW is to arrive at a town over two 0.140 ? lines. Estimate how much power is saved if the voltage is stepped up from 240 V to 2400 V and then down again, rather than simply transmitting at 240 V . Assume the transformers are each 99% efficient.