13. DNA methyltransferase:

A) Recognizes hemimethylated 5’-CpG-3’ sites on double stranded DNA

B) Adds a methyl group to select cytosine bases in the DNA

C) Is inhibited by decitabine

D) All of the above

E)   None of the above

13. Angelman Syndrome and Prader Willi Syndrome revealed that a similar chromosomal deletion could manifest as two very different (phenotypically distinct) syndromes. The genetic basis for the difference:
    1. Arises from changes in transcription due to promoter swapping at the deletion site.
    2. Depended on whether the deletion occurred on the maternally or the paternally inherited chromosome.
    3. Involves select, differentiated haploid cells inheriting the chromosome with the deletion after reductional cell division.
    4. Involved the generation of miRNA at the deletion site that silenced the wild type transcript on the other chromosome.
    5. Depended on the nurturing environment of the children, well-nurtured children developed Angelman Syndrome, while poorly-nurtured children developed Prader Willi Syndrome.

13. What epigenetic changes would lead to increased transcription?

1. Demethylation of the DNA
2. Acetylation of the histone N-terminal tails
3. Removal of histones from the DNA by remodeling factors
4. All of the above
5. None of the above

7. The costs of carrying inventory include all of the following except: *

a- Ordering costs.

b- Cost of warehouse space.

c- Insurance and handling costs.

d- Interest on funds tied up in inventory.

e- None of the above.

8. Once the break-even point is reached: *

a- The contribution margin ratio begins to decrease.

b- The variable expenses will remain constant in total.

c- The total contribution margin changes from negative to positive.

d- The net operating income will increase by the unit contribution margin for each additional item sold.

e- None of the above.

9. Allocated common fixed costs: *

a- Are always incremental costs.

b- Can make a product line appear to be unprofitable.

c- Are always relevant in decisions involving dropping a product line.

d- All of the above.

e- None of the above.

10. If Company C has a higher degree of operating leverage than Company D, then: *

a- Company C is less risky.

b- Company C is more profitable.

c- Company C has higher variable expenses.

d- Company C’s profits are more sensitive to percentage changes in sales.

e- None of the above.

QUESTION 33

1. The level of frictional unemployment is determined by

   		the flows of people into and out of employment.
   		the duration of the spells of unemployment.
   		the level of excess demand.
   		technological changes

2 points   

QUESTION 34

1. Employment contracts for the majority of American workers take the form of

   		formal documents precisely specifying in advance the obligations of each party
   		oral agreements that can be legally enforced when necessary.
   		a broad set of informal understandings between each party.
   		collective bargaining agreements made between an employer and a union.

2 points   

QUESTION 35

1. Suppose that the compensating differential associated with working in a noisy workplace is

   $500 per year. This $500 payment can be interpreted as

   		the amount sufficient to attract any worker to the noisy environment.
   		the amount that the marginal worker is willing to pay for a quiet environment.
   		the minimum amount necessary to attract a worker to the noisy environment
   		the most that any worker would pay for a quiet work environment.

2 points   

QUESTION 36

1. Demand deficient unemployment results from

   		a general slowdown in business activity.
   		real wages being inflexible downward
   		changes in the skills required of workers.
   		Both a and b

We are evaluating a project that costs $864,000, has an eight-year life, and has no salvage value. Assume that depreciation is straight-line to zero over the life of the project. Sales are projected at 7,000 units per year. Price per unit is $49, variable cost per unit is $33, and fixed costs are $765,000 per year. The tax rate is 35 percent and we require a return of 10 percent on this project.

1-Calculate the accounting break-even point. And the financial break even . 2 points

2-Calculate the base-case cash flow arid NP\/. What is the sensitivity of NP\/ to changes in the sales figure? Explain what your answer tells you about a 500-unit decrease in projected sales.

3-What is the sensitivity of OCF to changes in the variable cost figure? Explain what your answer tells you about a $1decrease in estimated variable costs.

4- Scenario Analysis In the above problem, suppose the projections given for price, quantity, variable costs, and fixed costs are all accurate to within a+-10 per-cent. Calculate the best-case arid worst-case NPV figures

Suppose Malaysia's production possibilities include a maximum of 70 units of rice or 280 units of lumber, and Canada's production possibilities include a maximum of 140 units of rice or 140 units of lumber. Then suppose each country initially allocates 50% of its labor to producing each product. a) Total production by the two countries equals 105 105 Correct tons of rice and 210 210 Correct ft3 of lumber. b) Now suppose that Malaysia increases the labor it allocates to lumber by 10%. Its lumber production rises by 28 28 Correct and its rice production falls by 7 7 Correct . c) If Canada reallocates its labor to increase its rice production by exactly the amount that Malaysia's rice production fell, by how much must its lumber production fall? 5 5 Incorrect ft3 d) State the combined effects on total production of the reallocations in part b and c. Total production of rice changes by 105 105 Incorrect tons. (include a negative sign, if needed) Total production of lumber changes by 231 231 Incorrect ft3. (include a negative sign, if needed)

Present and Future Values of Single Cash Flows for Different Periods Find the following values, using the equations, and then work the problems using a financial calculator to check your answers. Disregard rounding differences. (Hint: If you are using a financial calculator, you can enter the known values and then press the appropriate key to find the unknown variable. Then, without clearing the TVM register, you can "override" the variable that changes by simply entering a new value for it and then pressing the key for the unknown variable to obtain the second answer. This procedure can be used in parts b and d, and in many other situations, to see how changes in input variables affect the output variable.) An initial $300 compounded for 1 year at 4%. Round your answers to the nearest cent. $ 678.51 An initial $300 compounded for 2 years at 4%. Round your answers to the nearest cent. $ 912.46 The present value of $300 due in 1 year at a discount rate of 4%. Round your answers to the nearest cent. $ 368.45 The present value of $300 due in 2 years at a discount rate of 4%. Round your answers to the nearest cent. $ 273.98

The shape of the distribution of the time required to get an oil change at a 15​-minute ​oil-change facility is unknown.​ However, records indicate that the mean time is 16.8 minutes​, and the standard deviation is 4.3 minutes. Complete parts​ (a) through​ (c) below.

To compute probabilities regarding the sample mean using the normal​ model, what size sample would be​ required? Choose the required sample size below.

A. Any sample size could be used.

B. The normal model cannot be used if the shape of the distribution is unknown.

C. The sample size needs to be greater than 30.

D. The sample size needs to be less than 30. ​

(b) What is the probability that a random sample of n=35 oil changes results in a sample mean time less than 15 ​minutes?

(c) Suppose the manager agrees to pay each employee a​ $50 bonus if they meet a certain goal. On a typical​ Saturday, the​ oil-change facility will perform

35 oil changes between 10 A.M. and 12 P.M. Treating this as a random​ sample, at what mean​ oil-change time would there be a​ 10% chance of being at or​ below? This will be the goal established by the manager.