After watching the video Unions in America, answer the following:

Does anybody belong to a union?

What are your thoughts/perceptions about unions?

Do you believe that unions are necessary and ethical in the marketplace? Explain why or why not.

Define a subspace of a vector space V . Take the set of vectors in Rn such that th
coordinates add up to 0. I that a subspace. What about the set whose coordinates add
up to 1. Explain your answers.

Malaria is a disease that is caused by the eukaryotic parasite Plasmodium and is transmitted between individuals by the bite of infected mosquitoes. Different species of Plasmodium cause disease in different vertebrate species, but in all cases the parasite infects and destroys red blood cells. The repeated emergence of drug-resistant strains of Plasmodium parasites responsible for human infections has caused researchers to continually search for new drugs or combinations of drugs that can provide an effective treatment. A drug that has proven effective in recent years is artesunate, but now artesunate-resistant Plasmodium strains have also appeared.

Researchers investigated whether artesunate-resistant Plasmodium strains could be effectively treated by other drugs. In a mouse model of malaria, the researchers determined that a particular strain of artesunate-sensitive Plasmodium (ART-S) could be largely eliminated from the mice at a dose of 0.15 mg/kg. By repeated exposure of the artesunate-sensitive strain ART-S to increasing concentrations of artesunate, the researchers developed a Plasmodium strain that is highly resistant to artesunate (ART-R) and requires a minimum dose of 240 mg/kg to eliminate the parasites.

The researchers then compared how effectively several common antimalarial drugs eliminate the ART-S and ART-R strains in vitro. The researchers infected human red blood cells with the ART-S and ART-R Plasmodium strains and incubated the infected cells in tissue culture medium. They added serial dilutions of the drugs to replicate cultures and determined the IC50 for each drug, the concentration of the drug that reduced the parasite load in the red blood cells by 50% (Table 1).

Table 1. IC50 for common antimalarial drugs tested on artesunate-sensitive (ART-S) and artesunate-resistant (ART-R) Plasmodium strains

1. Plasmodium is an organism with both sexual and asexual life cycles. Describe the most likely cause of a heritable phenotypic change in some members of a population of asexually reproducing organisms. Explain how repeated exposure of the artesunate-sensitive Plasmodium strain to increasing concentrations of artesunate led to the development of the artesunate-resistant Plasmodium strain.

2. Based on the data, identify the drug that, from the ART-S strain to the ART-R strain, has the largest relative increase in the IC50. Based on the information provided about the mouse model, calculate how many times more sensitive the originalART-S Plasmodium strain is to artesunate than is the ART-R strain.

3. In the mouse model of malaria, the researchers injected Plasmodium-infected human red blood cells into the mice because the Plasmodium species had surface ligand proteins that bound only to cell membrane proteins of human red blood cells. Assume that the researchers noticed that some of the parasites no longer infected human red blood cells but instead infected mouse red blood cells. Predict the most likely cause of this change in the host specificity of the parasites. Plasmodiumreproduces both sexually in the host vertebrate and asexually in mosquitoes. The researchers claim that the Plasmodium organisms that infect the two different types of red blood cells are likely to evolve into two separate species of Plasmodium. Based on the biological species concept, provide reasoning that would support the researchers’ claim.

Racism, juries, and interactions: In a study of racism, Nail, Harton, and Decker (2003) had participants read a scenario in which a police officer assaulted a motorist. Half the participants read about an African American officer who assaulted a European American motorist, and half read about a European American officer who assaulted an African American motorist. Participants were categorized based on political orientation: liberal, moderate, or conservative. Participants were told that the officer was acquitted of assault charges in state court but was found guilty of violating the motorist’s rights in federal court. Double jeopardy occurs when an individual is tried twice for the same crime. Participants were asked to rate, on a scale of 1–7, the degree to which the officer had been placed in double jeopardy by the second trial. The researchers reported the interaction as F(2, 58) = 10.93, p < 0.0001. The means for the liberal participants were 3.18 for those who read about the African American officer and 1.91 for those who read about the European American officer. The means for the moderate participants were 3.50 for those who read about the African American officer and 3.33 for those who read about the European American officer. The means for the conservative participants were 1.25 for those who read about the African American officer and 4.62 for those who read about the European American officer. ***This prompt requires certain formatting so that you can draw tables and bar graphs. You can use Microsoft Excel or Microsoft Word, or any other word processing software to create your post/ post it as an attachment in the discussion. Draw a table of cell means that includes the actual means for this study. Do the reported statistics indicate that there is a significant interaction? If yes, describe the interaction in your own words. Draw a bar graph that depicts the interaction. Include lines that connect the tops of the bars and show the pattern of the interaction. Is this a quantitative or qualitative interaction? Explain. Change the cell mean for the conservative participants who read about an African American officer so that this is now a quantitative interaction. Draw a bar graph that depicts the pattern that includes the new cell means. Change the cell means for the moderate and conservative participants who read about an African American officer so that there is now no interaction. Draw a bar graph that depicts the pattern that includes the new cell mean

This discussion question will have you demonstrate your knowledge of the medical terms, understanding of the use of nouns, pronouns, and verbs, by creating a scenario of a patient. Research a medical disease and write 2-3 paragraphs to your classmates describing your patient’s condition using 20 of the words in Section 1, 2, and 3 of the textbook under “Medical Spelling.” You must highlight these words in yellow. You will also need to highlight at least ten nouns, ten pronouns, and ten verbs. Provide at least one reference to support your discussion of the disease.

There is plenty of information, choose a disease and go with it.

Suppose you are viewing some red light coming from a galaxy far, far away. The wavelength of the red light is expected to be 6300 nm if the relative speed of the galaxy with respect to your world is zero. That is, if the galaxy and you are not moving toward or away from each other. However, you observe a wavelength that is longer than expected. How would you interpret this observation?     Recall the frequency dependence of the Doppler shift: f’ = f (1 ⁺ u/c).

MERMED Inc. is a medical device manufacturer.

The company’s headquarters is located in Houston, Texas. It is a global leader in developing, manufacturing, selling and servicing diagnostic imaging and therapeutic medical devices used to diagnose and treat cardiovascular and other diseases. MERMED earned $300 million of revenue in 2015, while employing more than 10,000 people worldwide. One of it’s manufacturing plants is located in Dingle, Co. Kerry, Ireland. Tom Jones is the plant manager at the Dingle facility.

The Dingle site runs 12 hour shifts, 7 days a week. It has 1000 employees. It manufactures a variety of of medical devices (including Class III devices). A number of it's products are sold in the US and European markets. The facility has a Quality Management System in place. Their Quality Management System is in compliance with ISO 13485:2016 and 21 CFR 820. Their facility is frequently audited by Notified Bodies and the FDA.

The site was recently audited by corporate. The corporate auditing team were checking the site's compliance with ISO 13485:2016 and 21 CFR 820. The auditors found a number of potential non-conformances to  ISO 13485:2016 and 21 CFR 820.

You must complete 4 tasks (for each of the 5 incidents/questions):

1.   Review each of these potential non-conformances (5 incidents in total)

2. Determine if they are non-conformances against the requirements of the ISO13485:2016 AND 21 CFR 820.

3. If they are non-compliances, write down the specific clause numbers in ISO 13485:2016 AND specific section number of 21 CFR 820 which is applicable (write down the main clause/section in each regulation that the non-compliance is against).

Note:  ISO 13485:2016 and 21 CFR 820 are available in the "Additional Resources" section, under the section heading "Quality Systems Regulations (EU and US)" (contained within Section A Medical Device Regulatory Affairs).

4. Briefly EXPLAIN your decision in 100-170 words.

QUESTION 4

The operation of a weighing scale (equipments ID 186749) was reviewed by the inspector in the Box Packing section. The weighing scale was in use during the current shift. The operating procedure (SOP18654) for the scale states that it must be calibrated at the beginning and end of each shift. The operating procedure states that that the calibration of the scales is recorded in a log book(Calibration Log for ID 186749 ). The inspector asked to review this log book. The maintenance technician who was interviewed said that the log book was held by the maintenance technician on the night shift and he always kept it in his desk drawer which was locked.

MERMED Inc. is a medical device manufacturer.

The company’s headquarters is located in Houston, Texas. It is a global leader in developing, manufacturing, selling and servicing diagnostic imaging and therapeutic medical devices used to diagnose and treat cardiovascular and other diseases. MERMED earned $300 million of revenue in 2015, while employing more than 10,000 people worldwide. One of it’s manufacturing plants is located in Dingle, Co. Kerry, Ireland. Tom Jones is the plant manager at the Dingle facility.

The Dingle site runs 12 hour shifts, 7 days a week. It has 1000 employees. It manufactures a variety of of medical devices (including Class III devices). A number of it's products are sold in the US and European markets. The facility has a Quality Management System in place. Their Quality Management System is in compliance with ISO 13485:2016 and 21 CFR 820. Their facility is frequently audited by Notified Bodies and the FDA.

The site was recently audited by corporate. The corporate auditing team were checking the site's compliance with ISO 13485:2016 and 21 CFR 820. The auditors found a number of potential non-conformances to  ISO 13485:2016 and 21 CFR 820.

You must complete 4 tasks (for each of the 5 incidents/questions):

1.   Review each of these potential non-conformances (5 incidents in total)

2. Determine if they are non-conformances against the requirements of the ISO13485:2016 AND 21 CFR 820.

3. If they are non-compliances, write down the specific clause numbers in ISO 13485:2016 AND specific section number of 21 CFR 820 which is applicable (write down the main clause/section in each regulation that the non-compliance is against).

Note:  ISO 13485:2016 and 21 CFR 820 are available in the "Additional Resources" section, under the section heading "Quality Systems Regulations (EU and US)" (contained within Section A Medical Device Regulatory Affairs).

4. Briefly EXPLAIN your decision in 100-170 words.

QUESTION 4

The operation of a weighing scale (equipments ID 186749) was reviewed by the inspector in the Box Packing section. The weighing scale was in use during the current shift. The operating procedure (SOP18654) for the scale states that it must be calibrated at the beginning and end of each shift. The operating procedure states that that the calibration of the scales is recorded in a log book(Calibration Log for ID 186749 ). The inspector asked to review this log book. The maintenance technician who was interviewed said that the log book was held by the maintenance technician on the night shift and he always kept it in his desk drawer which was locked.

Objective: The objective of this assignment is to learn about how to use common concurrency mechanism.        

Task: In this assignment you will be doing the followings:

1. Write a program (either using Java, python, C, or your choice of programming language) to create three threads: one for deposit function and two for withdraw functions.

2. Compile and run the program without implementing any concurrency mechanism. Attach your output snapshot.

3. Now, modify your program to implement any concurrency mechanism. Compile and run. Attach your output snapshot.

Submission:

Submit your program with the output screenshots and explain your observations.

Write about the financial crisis in history. especially about the South Sea Bubble and the Latin American Crisis. Explain why the crisis happen? what were the causes of both crises? what were the results or effects? and After the crisis how the country recover from it?

Note: please write in your own words; do not copy and paste from online sources. the answer has to be in at least 250-300 words