Clinical Trial Between 2004 and 2007, the National Institutes of Health conducted a STEP vaccine clinical trial—Phase IIB "test-ofconcept" study. The STEP study is the name of a clinical trial to test an experimental human immunodeficiency virus (HIV) vaccine. The STEP study enrolled 3,000 participants at sites in Australia, Brazil, Canada, the Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, and the United States. The study was designed to test an HIV vaccine, which aimed to stimulate production of immune system T-cells that can kill HIV-infected cells. Based on its first evaluation of vaccine efficacy, the findings showed there were 24 cases of HIV infection among the 741 volunteers who received at least one dose of the investigational vaccine compared with 21 cases of HIV infection among the 762 volunteers who were vaccinated with the placebo. In volunteers who received at least two vaccinations, there were 19 cases of HIV infection among the 672 volunteers who received the investigational vaccine and 11 instances of HIV infection among the 691 volunteers who received placebo. The study investigators of the vaccine trials have decided to cease immunizations and are contacting study volunteers to inform them of the developments.

Reference: National Institutes of Health (2007). National Institute of Allergy and Infectious Diseases: Immunizations are discontinued in two HIV vaccine trials. Retrieved from National Institute of Allergy and Infectious Diseases Pages/step_statement.aspx.

Using the South University Online Library or the Internet, research further on the STEP study, the STEP vaccine clinical trials, and their parameters. Based on your research, understanding, and above information, answer the following questions:

Prior to beginning this study, how would you have described the risks and benefits of the study to participants?

What are the ethical issues surrounding this study at the beginning and when the decision was made to terminate the study?

The age x and resting heart rate y were measured for ten men, with the results shown in the table.

Test, at 10% level of significance, whether age is useful for predicting resting heart rate.

H₀:

H_a:

t-Test Statistic (round to three decimal places) =

Critical t-score (t αt α or t α / 2t α / 2, round to three decimal places) =  

Conclusion (write "R" for reject H₀, and "F" for fail to reject H₀):

A manager of a ski-station restaurant collected $90,000 of revenue in April, serving 9000 customers. For May she predicts a decrease in guests of 40%. What will be the amount of revenue she will collect, if she is planning to reduce her fixed costs, by reducing number of staff by 20%.

What role do customers play in a business? What is sales revenue and how does it relate back to customers? What does “Accounts Receivable” mean? What benefit does the A/R report provide? What are credit memos and are they a good thing? What is a Trial Balance? What does an account reconciliation provide?

The third worksheet ("Ex. 3") contains 2 4x4 matrices, plus space for a third. Write a program that will read the first 2 matrices into array "B" and "C" . Create a 3rd array, "A" that is the result of matrix B + matrix C (i.e |A| = |B| + |C|). Output that array in the indicated cells (upper left = cell K1) To do this, use the rule for array addition for each matrix element: aij = bij + cij where i and j indicate the location (row, column) of the matrix element. NOTE: You must use arrays to get credit for this exercise. Keep close track of which loop is representing which index.

(a) use the data n the table to construct a standardized p-chart,

(b) interpret your chart, and

(c) give reasons for out-of-control conditions

Distinguish between the Concepts of Social Responsibility Accounting (SRA) and Corporate Governance (CG), Discuss how best the SRA and CG will contribute in increasing the wealth of the shareholders?

Describe how the motility and secretions of the stomach contribute to the digestive process in a healthy human, making sure that you describe difference between the functional regions of the stomach.

How would you address systemic educational inequality between private and public school districts? Identify South Carolina and/or national policies that contribute to the inequalities.