A researcher designs an experiment to measure the effectiveness of the new ointment in treating shingles. Singles is a very serious, painful disease. A medical doctor examines the sixteen voluntary subjects. She finds four of subjects each with a moderate case of shingles and of these two are females and two are males. The other twelve subjects each have a severe case of shingles and of these eight are females and 4 are males. All subjects are aged 50 to 60, and except for shingles are in good health. For the standard ointment treatment, the doctor knows that females tend to respond better to the treatment than males do.

The statistician in charge of designing the experiment decides to conduct a double blind experiment using two treatment groups of subjects. Neither the doctor nor any of the subjects will know who receives which ointment. The control group will receive the standard ointment treatment for which the effectiveness is well known. The experimental group will receive new ointment. The two ointments are in identical tubes and both ointments appear identical. The subjects will receive detailed instructions on the application of the ointment. Each subject will apply the same amount of ointment three times a day, which is the recommended dosage of the standard ointment. They will have weekly follow up visits over two months after which the experiment will end. During weekly follow-up visits the doctor will assess if patients are correctly applying the ointment and use a Likert scale from 0, 1, 2, 3, to 4 to judge the severity of the rash with 0 indicating no rash and 4 a very severe rash.

Because males and females tend to respond differently to the standard treatment, the researcher must block males and females into a block of all males and another block of all females. For the male block, he randomly assigns one male with moderate case of shingles to new ointment treatment and the other male to the standard ointment treatment. Likewise, he randomly randomly assigns two of males with a severe case to new ointment treatment and the other two to the standard ointment treatment. Similarly, for the female block, he randomly assigns one moderate case to each of the two treatments. In addition, he randomly assigns four of females with a severe case to new ointment treatment and the other four to the standard ointment treatment. He runs the experiment for two months. For both males and females within each block and between each block, he compares how well and how fast the new ointment and the standard ointment work.

A.Why did the design not include a placebo?

B. Does the lack of a placebo put the results into question?

C. Do you see any design flaws in the original design?

Assume individuals with other serious health problems like cancer have a much harder time curing shingles than otherwise healthy individuals and that generally people older than 70 are also harder to cure.

4) When the experiment is replicated, should this additional information be taken into account? Describe how this would affect the design of the experiment.

Assume you are a vice-president in charge of a new business-to-business e-commerce division of a well-known major international auto parts manufacturer.

A) A cyber squatter has registered the company name as a domain Web name. What are your options to secure the domain name for your company?

B) Discuss the steps you should take to ensure worldwide protection of your domain name.

The streamlines of the velocity field

v(x,y,z)=xlnzi+ylnzj+xk

have equations:

how to calculate External Quantum Efficiency from I-V-L graph? Explain in details.

Ignoring extinction effects, does a star's "color"

(B-V) depend on its distance? Explain.

prepare 200mL of a 6% w/v NaOH solution from stock NaOH (FW 40)

Explain why reducing the size of U, V , and ? may not have significant effect on the quality of an image.