Part I – Infertility Issues
Jane sat nervously in the examination room. She had no idea what to expect. Her husband, Brian, gave her a

reassuring smile and squeezed her hand. There was a knock on the door and then it opened to admit the physician.

“Hello, Jane. I’m Dr. Klein and I’ll be doing your fertility assessment today.”

“It’s nice to finally meet you Dr. Klein. This is my husband, Brian.” The two men smiled at each other and shook hands.

Dr. Klein sat down on the stool and opened up a thick file. “Jane, I’ve looked over the medical files that you had sent over to our office and I’ve examined the preliminary blood tests you had done at our office last week. I just need to ask you a few questions, and then we’ll do a quick examination to help me try to get to the cause of your fertility issues.”

“Sure, I’ll answer the best I can. Was anything missing from my medical records?” Jane asked, concerned that she had forgotten to send something the doctor would need. “We’ve been trying to get pregnant for two years and nothing has worked. We both want kids so badly, and a friend recommended you, so I hope you can help us.”

Dr. Klein smiled kindly at Jane and Brian. They were young, and there was no obvious explanation in Jane’s file for her infertility. Dr. Klein’s initial notes about Jane’s medical history and recent blood tests included the following:

• 28-year-old Caucasian female.

• Diagnosed at 14 with Irritable Bowel Syndrome (IBS).

• Diagnosed with anemia in her early 20s; current hemoglobin levels at 7 gm/dl.

• Active lifestyle until past year; used to exercise daily and run half marathons until recent joint pain hindered her.

• Broken wrist last year after a minor fall.

• No history or abnormal pelvic exams or PAP smears.

• Hormone levels (estrogen, progesterone, LH, and FSH) in normal ranges.

• Patient reports her menstrual cycles are not very regular.

• Positive for several classes of autoantibodies.

  Looking up from his notes, Dr. Klein asked, “Jane, have you been able to control your IBS symptoms? Do you still have bouts of diarrhea or constipation despite a healthy diet?”

  “I’ve never really been able to control the symptoms as much as I’d like,” Jane said. “It’s something I’ve just learned
  to live with. I’ve tried all sorts of different diets and nothing seems to help. I felt a little better on the new low carbohydrate diet that people have been talking about, but it was really hard to stick to.” She looked questioningly at her husband, silently wondering what her stomach problems could have to do with her fertility issues.

“When Good Antibodies Go Bad” by Cozine and Gripka Page 1

“One of the things we test your blood for are the presence of autoantibodies. Recent studies indicate that women with infertility problems may have higher levels of autoantibodies in their blood. Your test results show that you are positive for several autoantibodies at levels higher than we would expect in a healthy female.” Dr. Klein could see the obvious confusion on Jane and Brian’s faces. “Do either of you know what antibodies or autoantibodies are?”

Questions

1. Pretend you are Dr. Klein and first explain what an antibody is to Jane and Brian.

2. Relate the basic definition of an antibody to explain an autoantibody in terms Jane and Brian will be able to understand.

3. What are three examples of autoantibodies that can be detected and the diseases they are associated with?

4. Given her digestive problems and the presence of autoantibodies (indicating that her condition is autoimmune), what are some possible diseases (besides IBS) that Jane might have?

Consider the following three market price data.

(a) Enter the following sales data using Excel.

(b) Use LINEST to find a linear price function for the above data for three markets. (Note: You will be using the format (Price = b + m1*x1 + m2*x2 + m3*x3) where Price = P(x1, x2, x3) and the values for b, m1, m2, and m3 are all numerical values. Enter all values correct to 2 decimal places.)
P(x1, x2, x3) =  +  *x1 +  *x2 +  *x3

(c) Use the values for b and the three slopes to predict the price when the sales are x1 = 15, x2 = 20, and x3 = 15.
P(15, 20, 15) = $  

(d) Repeat (a) - (c) when one additional price data is used where x1 = 14, x2 = 12, x3 = 12 and Price A = $89. (Note: Add this new information into your spreadsheet by adding an extra row at the bottom.)

New linear price function
P(x1, x2, x3) =  +  *x1 +  *x2 +  *x3

New price prediction
P(15, 20, 15) = $

Phonesmart is having a sale on Bananas. If you buy one Banana at full price, you get a second at half price. When couples come in to buy a pair of phones, sales of Apricots and Bananas are equally likely. Moreover, given that the first phone sold is a Banana, the second phone is twice as likely to be a Banana rather than an Apricot. What is the probabilty that a couple buys a pair of Bananas?

Please I need a thorough detailed explaination of the answer. Thank you !

You have owned the following two stocks over the past 5 years

a. What is the standard deviation of a portfolio's return in which 50% of your portfolio is in each stock? ( Hint: Calculate the holding period return first)

Please show all work and finance formulas.

Given below are the room price (in $) paid by U.S. travellers in six British cities in 2009:

185 160 126 116 112 105

1. Compute the mean, median, and mode.

2. Compute the range, variance, and standard deviation.
3. Based on the results of (a) and (b), what conclusions can you reach concerning the room price (in $) paid by U.S. travellers in 2009?
4. Suppose that the first value was 85 instead of 185. Repeat (a) through (c), using this value. Comment on the difference in the results.

For a price-searcher, assume the demand curve is Q = 10 - P.

a.)        Construct a four-column table of P and Q with P ranging from 10 to 0. Calculate TR and MR and add them to your table.

b.)       Graph D and MR. (Plot points—with $ on the vertical axis and Q on the horizontal axis.

c.)        Why is P > MR (after the first unit)—or in other words, what is the good news and bad news for the price searcher as Q increases?

1. The first bitcoin transaction was conducted on January 12th 2009. In its early days, the value of bitcoins were practically zero (In March 2010, a user auctioned 10,000 bitcoins for a total of $50 but no buyer was found.) By December 17th, 2017, the price of bitcoin has reached an all-time high of $19,783. As of today (March 12, 2019), its price is $3,858.

a. In what ways is bitcoin similar to a Ponzi scheme?

b. In what ways is bitcoin different?

This is a two-part question: We have a firm that needs $1000 to obtain a new machine for its business. It can either issue stock or bonds, or some combination of both. If it issues bonds it will have to pay $8.00 in interest for every $100 borrowed. Finally, assume the company will earn $150 in good years and $75 in bad years, with equal probability. The first part of the question is to (a) determine the payment to the equity holders under the following three scenarios: (i) the first is the firm uses 0% debt financing; (ii) the second is the firm uses 50% debt financing, and (iii) the third finds the firm using 80% debt financing. The second part of the question is to (b) determine the expected equity return (%) under each scenario.

An Italian company, New Century Corp, enters into a 2-year interest rate swap with Northern European Bank. The notional principle of the swap is €100 million. Payments will be made semiannually on the basis of 180/360 (180 days in the settlement period and 360 days per year). New Century will pay a fixed rate of 5% and receive floating rate Euribor plus 2%. The realization of the 180-day Euribor rates are as below:

Current: 3%             

In 6 months: 2.8%         

In 12 months: 3.4%    

In 18 months: 3.7%

A. Determine the initial exchange of cash that occurs at the start of the swap.

B. Determine the semiannual payments for the first year (first half, second half)    

C. Determine the final exchange of cash that occurs at the end of the swap.

A municipal water authority is considering the installation of a new water system. Two options are being considered. The first option is a steel pipeline with an installation cost of $225 million. Annual maintenance and pumping costs begin at $15 million and increase by $1.0 million per year. The second option is a gravity fed concrete canal with an installation cost of $400 million. Annual maintenance costs begin at $0.5 million and increase by $0.4 million per year. The water system is expected to last 100 years and the interest rate is 5% per year compounded yearly. What is the present worth of the first option and second option? Report your answer in millions of dollars.

Please answer full question, and include cashflow diagram if possible.