This is a very simpllistic approach to protein folding, which ignores solvent and volume effects, but it allows us to practice what we have learned about thermodynamics and kinetics. Enzymes are long chains of amino acids that have to fold in the proper way so as to exhibit enzyme activity. They can catalyze certain reactions. Let us pick a reaction in the human body at 37 C, we will call it enzyme X.

Let's say that enzyme X is the catalyst responsible for breaking starch down to individual glucose molecules. What of the following things can happen to the starch and enzyme system if you rainse the temperature?

a-the rate of the reaction of starch going to glucose will increase

b-nothing should happen since a catalyst does not affect the equilibrium

c-the enzyme could stop working effectively becauset the folded form would stop being made and would start to unravel if the process is reversible

d-the equilibrium constant will get bigger to favor the glucose side more

QUESTION FOR ALL - MY MEDIUM IMPACT TRUMPS YOUR HIGH PROBABILITY!

So, we are evaluating our probabilities on an ordinal scale of Very High, High, Medium, Low, Very Low. And we are using the same scale for impacts. A little combinatorial math will tell you that gives us 25 combinations of individual combined ratings.

We know that a Very High probability with a Very High impact will be the top of our list. Likewise, we know a very low probability with a very low impact will be at the bottom. It’s the stuff in the middle that gives us so much problem.

Is a High Probability Medium impact risk a bigger problem than a Medium Probability High impact risk, for example?   We have many of these pairs to sort through if we are going to come up with a combined risk rating for each identified risk.

How do we do that, people? And once we do, how do we document it clearly?

Thoughts, ideas, examples?

help please

Please I need today answer for This question and it is very important and I need solution for this issue with all the details , and help me with all the details.Please write your answer to me by typning  not by hand writing, so that I can read and understand your answer clearly.thanks in advance/Ha

Q.1) Wages in the US have been steadily increasing since the 1980s. This question is about relating this increase in wages to changes in female labor supply over time. a) Using the basic static model of individual labor supply, discuss both graphically and explain in your own words how this increase in wages can have contributed to the increase in female labor force participation in the US over time.

b) What impact will the increase in the wage rate have on hours worked (of females already working in the 1980s)? Discuss all relevant effects. Which effect dominates if hours worked increase following an increase in the wage rate? You do not need to draw a graph for this answer.

It is believed by many experienced auditors that risk in payroll is an issue primarily at two locations – (1) when an individual enters the payroll system and (2) when the person leaves the payroll system. Once an individual is on the payroll, then routine occurrences such as annual raises are recorded routinely. The concern is with the possibility of “ghosts”; individuals who do not exist but get a paycheck. Obviously, someone is getting the paycheck and segregation of duties between human resources and payroll can mitigate this risk.

What additional internal controls can you suggest that you think might additionally reduce this risk of payroll ghosts? Please write an articulate, thoughtful response to the question above. This response should be 200-250 words in length

Assume that Carbondale Company expects to receive S$500,000 in one year. The existing spot rate of the Singapore dollar is US$0.70. The one-year forward rate of the Singapore dollar is US$0.72. Carbondale created a probability distribution for the future spot rate in one year as follows:

Assume that i) one-year put options on Singapore dollars are available, with an exercise price of US$0.73 and a premium of US$0.04 per unit and ii) one-year call options on Singapore dollars are available, with an exercise price of US$0.70 and a premium of US$0.03 per unit. Assume the following money market rates:

Given this information, evaluate the use of forward hedge, money market hedge, a currency options hedge. Which hedge is most appropriate and why? Consider the possibility of not hedging, what do you recommend?

Alligator, Inc.

Alligator, Inc. is a shoe designer, manufacturer, and distributor that launched its business in 2012. Although the company operates globally, its headquarters location is in Arteixo, Galicia, Spain, which coincidentally is the central location for Zara, the flagship chain store of the Inditex group, the world’s largest apparel retailer. The best-selling brand of Alligator, Inc. is its Gators™ model, which is a market leader in the funky, brightly-colored, lightweight shoe market that has enjoyed unexpectedly high demand in recent years. Made of a highly-resilient, space-age plastics material, Gators™ success is related also to the fact that each pair includes “one-size fits all” orthotics to meet the needs of individual consumers. Alligator, Inc. has patented the processes relating to the manufacture of the orthotics, and the overall value of this product innovation is similar to the way in which the super-secret formula for Coke is valuable to Coca-Cola, Inc.

The Alligator supply chain begins with retail consumers who are located in regions throughout the world. The Gators™ product is available for consumers at a wide variety of department stores, airport kiosks, Internet, and a select number of Alligator stores located primarily in developed countries. In addition to proprietary manufacturing facilities in Spain, Gators™ are produced by contract manufacturers in the Shenzhen area of China and in Brasilia, Brazil. Generally, the manufacturing costs per unit were lower in Shenzhen and Brasilia, and somewhat higher in Spain. Conversely, the quality of Gators™ manufactured in Spain was considerably better than that of the other locations. The markets served by the respective manufacturing facilities were those that were in greatest proximity.

The supply side of the Gators™ supply chain was a little more complicated, as most inputs to the finished product were available from suppliers in the regional markets, but the custom-fit orthotics were all produced in University Park, PA in the United States. This is because the developers of the orthotics technology were professors in the supply chain and information systems and footwear technology departments at Penn State University. Overall, Alligator’s relationships with its suppliers could have benefited from better coordination, and more timely and complete exchanges of information. At the time that this case study was published, Alligator was in the process of designing an IT capability that would capture point-of-sale information, for further use in streamlining and aligning supply chain operations. Also, the sales of Gators™ exhibited seasonal variation, but to some extent seasonal sales in the southern hemisphere complemented sales in the northern hemisphere.

To help address some of the supply chain issues facing Alligator, Bryson Wilde has recently been hired as the new SVP Supply Chain, and Molly Walters has been selected as the first chief information officer for Alligator. Collectively, and with the help of consultant Anna Walters, this group has taken time so far to visit the company’s global facilities and to become aware of the situation, problems, and concerns that are faced by Alligator, Inc. with regard to the Gators™ product. The following are some of the questions that will need to be addressed by this group.

2. What are the impacts of less-than-perfect demand forecasts for Alligator products, including Gators™, and of volatility in the length and cost the supply chain services needed to move components from suppliers to manufacturing sites, and the subsequent movement of finished products to market? What should be done to mitigate these problem areas?

Ratio of Liabilities to Stockholders' Equity and Times Interest Earned

Hasbro, Inc. and Mattel, Inc., are the two largest toy companies in North America. Condensed liabilities and stockholders' equity from a recent balance sheet are shown for each company as follows (in thousands):

The income from operations and interest expense from the income statement for both companies were as follows (in thousands):

a. Determine the ratio of liabilities to stockholders' equity for both companies. Round to one decimal place.

b. Determine the times interest earned ratio for both companies. Round to one decimal place.

Write a C++ program that will be an information system for Oregon State University using classes as well as demonstrating a basic understanding of inheritance and polymorphism.
You will create a representation of an Oregon State University information system that will contain information about the university. The university will contain a name of the university, n number of buildings, and m number of people. People can be either a student or an instructor. Every person will have a name and an age. Every student will have also have a GPA, but an instructor will NOT have a GPA. Every instructor will have an instructor rating, but a student will NOT have an instructor rating. Every building will have a name, the size in sqft (preferred the real value which you need to look up), and an address (stored as a string, also preferred to look this up).
People will contain a method called “do_work” that will take in a random integer as a parameter that represents how many hours they will do work for. If the person is a student, a message will be printed to the screen that says “PERSON_NAME did X hours of homework.” If the person is an instructor, a message will be printed to the screen that says “Instructor PERSON_NAME graded papers for X hours.” You will need to fill in the appropriate values.
The student GPA can either be an input from the user or randomized, but it must be between 0.0 and 4.0. It cannot be preset. The instructor rating can either be an input from the user or randomized, but it must be between 0.0 and 5.0. The ages of a person can be randomized or an input, but make it realistic. You can choose whether it is randomized or user input, or both.
The university will contain a method that will print the name and address of all the buildings in its information system and another method that will print the name of all the people. The name of the university MUST be “Oregon State University” (because we are the best).
You will manually instantiate at least 1 student, 1 instructor, and 2 buildings, then give them values and store them appropriately in the university object. You can do this in whatever fashion you wish.
You will have a menu that does at least the following:
1) Prints names of all the buildings
2) Prints names of everybody at the university
3) Choose a person to do work
4) Exit the program
Note that option 3 will require you to print another menu that gives options for each person.
You may create any other functions, methods, member variables, etc. to modularize your code and complete the lab.
You may use vectors for this assignment if you so choose.
(10 pts) Program Style/Comments
In your implementation, make sure that you include a program header in your program, in addition to proper indentation/spacing and other comments! Make sure you review the style guidelines for this class, and begin trying to follow them, i.e. don’t align everything on the left or put everything on one line! Also view the “Things not to do in the code” page and the “Things you need to do in your code” page as you will be held to these.

Add an option to save the information system to a file, and add an option to read a saved information system from a file so that you can close the program, but not lose information. This will also require you to be able to add people and/or buildings to the program during runtime. This is an all or nothing extra credit (you will not get partial points for partial completion).

Fanning Corporation’s balance sheet indicates that the company has $550,000 invested in operating assets. During 2018, Fanning earned operating income of $60,500 on $1,100,000 of sales.

Required

1. Compute Fanning’s profit margin for 2018.

2. Compute Fanning’s turnover for 2018.

3. Compute Fanning’s return on investment for 2018.

4. Recompute Fanning’s ROI under each of the following independent assumptions:
   (1) Sales increase from $1,100,000 to $1,320,000, thereby resulting in an increase in operating income from $60,500 to $67,320.
   (2) Sales remain constant, but Fanning reduces expenses, resulting in an increase in operating income from $60,500 to $62,700.
   (3) Fanning is able to reduce its invested capital from $550,000 to $440,000 without affecting operating income.

Fanning Corporation’s balance sheet indicates that the company has $550,000 invested in operating assets. During 2018, Fanning earned operating income of $60,500 on $1,100,000 of sales.

Required

1. Compute Fanning’s profit margin for 2018.

2. Compute Fanning’s turnover for 2018.

3. Compute Fanning’s return on investment for 2018.

4. Recompute Fanning’s ROI under each of the following independent assumptions:
   (1) Sales increase from $1,100,000 to $1,320,000, thereby resulting in an increase in operating income from $60,500 to $67,320.
   (2) Sales remain constant, but Fanning reduces expenses, resulting in an increase in operating income from $60,500 to $62,700.
   (3) Fanning is able to reduce its invested capital from $550,000 to $440,000 without affecting operating income.