Recent headlines have highlighted the spread of MRSA infection in the United States. Accoridng to the CDC, MRSA is responsible for over 90,000 serious infections and over 18,000 hospital stay-related deaths per year in the United States. These MRSA strains are responsible for many serious skin and soft tissue infections, as well as pneumonia. One major problem with MRSA is that occasionally the skin infection can spread to other organs of the body with more severe, life threatening symptoms, including necrotizing fasciitis and necrotizing pneumonia, followed by sepsis and toxic shock, and then death in up to 50% of cases. A striking finding about these infections is that they occur in young immunocompetent patients who were previously healthy. MRSA is resistant to several commonly prescribed antibiotics that are usually effective against gram-positive bacteria (methicillin, penicillin, and cephalosporins), and an infection with MRSA strain can be deadly if left untreated. MRSA is subcategorized as community aquired or hospital aquired, depending on how the infection is usually aquired. Most community aquired MRSA strains are still sensitive to many antibiotics, such as trimethoprim, tetracycline, and clindamycin, but hospital aquired MRSA strains are often resistant to these drugs will still sensitive to vancomycin and linezolid.

A) Provide common mechanism that accounts for the observed resistance of MRSA to methicillin, penicillin, and cephalosporin. Provide two different strategies that could be used to overcome this particular resistance.

B) For each of the antibiotics trimethoprim, tetracycline, and clindamycin, provide a possible mechanism to account for the observed resistance of HA-MrSA to the antibiotic. Provide a strategy that could be used to treat patients infected with HA-MRSA resistant to these antibiotics.

C) Why would HA-MRSA strains that are resistant to methicillin, penicillin, cephalosporins, trimethoprim, tetraculine and clindamysic still show sensitivity to vancomycin and linezolid?

D) Although CA-MRSA is resistant to clindamycin, treatment with clindamycin in combination with rifampin results in an increase in the 50% lethal dose (LD50) value from 10 without antibiotic treatment to 10^4 with rifampin to 10^8 for combined treatment with clindamycin and rifampin. In addtion, treatment with clindamycin enhanced opsonization of CA-MRSA by macrophages. What possible mechanism(s) could account for these observations (i.e., change in the LD50 value and enhanced opsonization)? Provide your rationale. Provide an experiment that could be performed to confirm your hypothesis.

1.Identify three macroeconomic variables in the United States that impact the supply and/or demand of the product or service produced by the company you selected for your microeconomic/macroeconomic analysis papers. ( Walmart's Neighborhood market is the service)

*I have identified Inflation, Unemployment and Interest rate but would like some insight on each element and sources to cite if possible.

2. Interpret the trends of the three selected macroeconomic variables for the past three years and evaluate how these trends will likely impact the supply and demand of your chosen product or service as well as the financial performance of your chosen company. (Walmart's Neighborhood market is the service)

I need some ideas here and some citation sources as well.

The international tax code affects the United States economy. In this discussion, you will comment on the complexity of the tax code and how the international tax code interacts with the U.S. tax code.

It was mentioned in our textbook that Pam Olson, former Treasury Assistant Secretary for Tax Policy, was quoted as saying, “It is difficult to predict the future of an economy in which it takes more brains to figure out the tax on our income than it does to earn it.” Read Testimony of Pamela Olson Before the Senate Committee on International Tax Policy and Competitiveness and comment on your experience with the complexity of the tax code. Why should it change to become more competitive with other countries? Why is international tax so important to the U.S. tax code? Cite specific code sections that you believe should change.

The probability that a person in the United States has type

B​+

blood is

10​%.

Five

unrelated people in the United States are selected at random. Complete parts​ (a) through​ (d).

​(a) Find the probability that all

five

have type

B​+

blood.The probability that all

five

have type

B​+

blood is

nothing.

​(Round to six decimal places as​ needed.)

​(b) Find the probability that none of the

five

have type

B​+

blood.The probability that none of the

five

have type

B​+

blood is

nothing.

​(Round to three decimal places as​ needed.)

​(c) Find the probability that at least one of the

five

has type

B​+

blood.The probability that at least one of the

five

has type

B​+

blood is

nothing.

​(Round to three decimal places as​ needed.)

​(d) Which of the events can be considered​ unusual? Explain. Select all that apply.

A.

The event in part​ (b) is unusual because its probability is less than or equal to 0.05.

B.

The event in part​ (c) is unusual because its probability is less than or equal to 0.05.

C.

None of these events are unusual None of these events are unusual.

D.

The event in part left parenthesis a right parenthesis is unusual because its probability is less than or equal to 0.05The event in part (a) is unusual because its probability is less than or equal to 0.05.

The mean cost of domestic airfares in the United States rose to an all-time high of $375 per ticket. Airfares were based on the total ticket value, which consisted of the price charged by the airlines plus any additional taxes and fees. Assume domestic airfares are normally distributed with a standard deviation of $115. Use Table 1 in Appendix B.

a. What is the probability that a domestic airfare is $540 or more (to 4 decimals)?

b. What is the probability that a domestic airfare is $255 or less (to 4 decimals)?

c. What if the probability that a domestic airfare is between $310 and $500 (to 4 decimals)?

d. What is the cost for the 5% highest domestic airfares? (rounded to nearest dollar) (X) $ or (more/less)

The SAT is a standardized college admissions test used in the United States. The following two multi-part questions will ask you some questions about SAT testing.

This is a 6-part question asking you to determine some probabilities of what happens when a student guessed for all of their answers on the SAT. Use the information below to inform your answers for the following questions.

An old version of the SAT college had a -0.25 point penalty for every incorrect answer and awarded 1 point for a correct answer. The quantitative test consisted of 44 multiple-choice questions each with 5 answer choices. Suppose a student chooses answers by guessing for all questions on the test.

1. What is the standard error of guessing on all 44 questions? Use the Central Limit Theorem to determine the probability that a guessing student scores 8 points or higher on the test.

Include Graphs

The United States' economy is growing at a faster rate than the economy of its trading partner, the United Kingdom. As a result, the rate of American inflation is increasing.

1. Draw correctly labeled graphs to show how the increase in inflation will affect the supply of the U.S. dollar and demand for the British pound in the foreign exchange market.
2. Based on the scenario, what will happen to the value of the U.S. dollar? Explain. (Make sure you use the costs of foreign and domestic goods in your explanation.)
3. Based on the changing value of the U.S. dollar in part (B), how will U.S. net exports be affected? Expla

1.If approximately one in every 2500 white individuals in the united states is affected by the autosomal recessive disease cystic fibrosis, what are the frequencies of both the dominant and recessive alleles in the populations ?

If 14% of individuals in a population have the reseccive phenotype (aa), what percentage of the population is heterozygous ?

I need this answered with a legibale explanation step by step in a simple manner

Fresh!Now! is a chain of grocery stores in the United States with 1921 grocery stores in total, some of which also sell bakery goods and freshly made food-to-go. Fresh!Now!’s goal is to provide good quality fresh vegetables at affordable prices. However, given the existing market of organic food supplies, Fresh!Now! is facing tremendous competition. They realize that Fresh!Now! has to make their stores more attractive to customers.

In 19 stores across Massachusetts and New York, they have implemented a new concept to present the vegetables in the stores and have collected information of the average daily profit of leafy vegetables (in dollar) per customer per store (see table below). Janine, the head of the analytics department at Fresh!Now!, has tasked you with developing an anlaysis to better understand if the new concept has any effect.

1. Your first task it to create a 95% confidence interval for the mean of the dataset using the sample collected from Massachusetts and New York.

What is the upper limit of this confidence interval?

Round your answer to three decimals places (e.g. if your calculation results in 12.9237 put in 12.924).

2. What is the lower limit of this confidence interval?

Round your answer to three decimals places (e.g. if your calculation results in 12.9237 put in 12.924)..

3. To understand if the new concept has taken effect, you want to conduct a hypothesis test. Average daily profit per customer per store for the leafy vegetables in all other Fresh!Now! grocery stores is 14.

You formulate the following hypothesis test:

H0: Average daily profit at Fresh!Now! in the New York/Massachusetts stores is not higher than the average daily profit of all other Fresh!Now! grocery stores at a confidence level of 95%.

H1: Average daily profit at Fresh!Now! in the New York/Massachusetts stores is higher than the average daily profit of all other Fresh!Now! grocery stores at a confidence level of 95%.

Calculate the test-statistic for the hypothesis test above.

Fresh!Now! is a chain of grocery stores in the United States with 1879 grocery stores in total, some of which also sell bakery goods and freshly made food-to-go. Fresh!Now!’s goal is to provide good quality fresh vegetables at affordable prices. However, given the existing market of organic food supplies, Fresh!Now! is facing tremendous competition. They realize that Fresh!Now! has to make their stores more attractive to customers.

In 19 stores across Massachusetts and New York, they have implemented a new concept to present the vegetables in the stores and have collected information of the average daily profit of leafy vegetables (in dollar) per customer per store (see table below). Janine, the head of the analytics department at Fresh!Now!, has tasked you with developing an anlaysis to better understand if the new concept has any effect.

Your first task it to create a 95% confidence interval for the mean of the dataset using the sample collected from Massachusetts and New York.

Question 1 What is the upper limit of this confidence interval?

Question 2 What is the lower limit of this confidence interval?

To understand if the new concept has taken effect, you want to conduct a hypothesis test. Average daily profit per customer per store for the leafy vegetables in all other Fresh!Now! grocery stores is 14.1.

You formulate the following hypothesis test:

H0: Average daily profit at Fresh!Now! in the New York/Massachusetts stores is not higher than the average daily profit of all other Fresh!Now! grocery stores at a confidence level of 95%.

H1: Average daily profit at Fresh!Now! in the New York/Massachusetts stores is higher than the average daily profit of all other Fresh!Now! grocery stores at a confidence level of 95%.

Question 3 Calculate the test-statistic for the hypothesis test above.

Question 4

Please select the result of your hypothesis test:

Choose the correct answer.

A: Fail to reject H0: You are not 95% confident that the mean profit in the Massachusetts/Boston stores is higher than the population mean.

B: Accept H0: Profit in the Massachusetts/Boston stores is lower than the population mean at the 95% confidence level.

C: Reject H0: You are 95% confident that the mean profit in the Massachusetts/Boston stores is higher than the population mean.

D: The result of your hypothesis test does not tell you if you can reject H0 or not.

Question 5 Calculate the p-value for the hypothesis test above.