How does the Near Attack Conformation (NAC) contribute to enzyme function? How can an enzyme put a substrate into an energetically unfavorable conformation? How does modern drug design utilize NAC? Please go into detail, provide examples, and use diagrams to help illustrate your explanation. Especially use diagrams please.  

NAC means "Near Attack Conformation". I am struggling to understand how all of these relate. Thank you so much for the help!

1. In 2017, GREEN CORPORATION acquired a silver mine in Benguet. Because the mine is located deep in the Benguet mountains, Green was able to acquire the mine for the low price of P50,000.

In 2018, Green constructed a road to the silver mine costing P5,000,000. Improvements to the mine made in 2018 cost P750,000. Because of the improvements to the mine and the surrounding land, it is estimated that the mine can be sold for P600,000 when the mining activities are complete.

During 2019, five buildings were constructed near the mine site to house the mine workers and their families. The total cost of the five buildings was P1,500,000. Estimated residual value is P250,000. In 2017, geologists estimated 4 million tons of silver ore could be removed from the mine for refining.

During 2020, the first year of operations, only 5,000 tons of silver ore were removed from the mine. However, in 2021, workers mined 1 million tons of silver. During that same year, geologists discovered that the mine contained 3 million tons of silver ore in addition to the original 4 million tons. Improvements of P275,000 were made to the mine early in 2021 to facilitate the removal of the additional silver.

Early in 2022, an additional building was constructed at a cost of P225,000 to house the additional workers needed to excavate the added silver. This building is not expected to have any residual value.

In 2022, 2.5 million tons of silver were mined and costs of P1,100,000 were incurred at the beginning of the year for improvements to the mine.

Requirements:

1. Depletion from 2020 to 2022.
2. Depreciation from 2020 to 2022.

Water will be pumped from a reservoir free surface of which is at an elevation of “z1” to reservoir the free water surface of which is at “z2”. Both of the reservoirs’ free surfaces at atmospheric pressures.Design a piping system that transmits water from the lower reservoir to the upper reservoir at a volumetric flow rate of Q (m3 /h).

Q = 200 (m3/h) Za = 10(m) Zb= 60 (m) Zc = 75 (m) L1=200 (m) L2=125 (m) "Pipe material is "Commercial Stainless Steel" "

1) Consider necesssary fittings( valves, elbows….)

2) Given data and cost elements, determine the optimum pipe diameter of the system . In order to do this:

3) Write the energy equation between z1 and z2 by taking the major losses associated with the pipe, minor losses associated with the fittings, sudden contraction, and expansion regions inside the system and the pump total head rise ”hp” into account .

4) The average velocity of the water inside your piping system should be between 0.1 and 5 m/s. 5) Calculate the head rise “hp” that must be provided by the pump.

6) Choose a pump that provides a head rise of ”hp” (that you calculated) near its most efficient working flow rate at your given flowrate Q from the local manufacturer’s catalogues.

7) Find the cost of the pipe per one meter (TL/m) and unit electricity price ( TL/kWh). Neglect cost of the pump or pumps.

Lavage Rapide is a Canadian company that owns and operates a large automatic car wash facility near Montreal. The following table provides data concerning the company’s costs:

For example, electricity costs are $1,100 per month plus $0.06 per car washed. The company expects to wash 8,500 cars in August and to collect an average of $6.10 per car washed.

The actual operating results for August appear below.

Required:

Prepare a flexible budget performance report that shows the company’s revenue and spending variances and activity variances for August. (Indicate the effect of each variance by selecting "F" for favorable, "U" for unfavorable, and "None" for no effect (i.e., zero variance). Input all amounts as positive values.)

Lavage Rapide is a Canadian company that owns and operates a large automatic car wash facility near Montreal. The following table provides data concerning the company’s costs:

For example, electricity costs are $1,200 per month plus $0.06 per car washed. The company expects to wash 8,000 cars in August and to collect an average of $6.20 per car washed.

The actual operating results for August appear below.

Required:

Prepare a flexible budget performance report that shows the company’s revenue and spending variances and activity variances for August. (Indicate the effect of each variance by selecting "F" for favorable, "U" for unfavorable, and "None" for no effect (i.e., zero variance). Input all amounts as positive values.)

ch8 exer #3

Lavage Rapide is a Canadian company that owns and operates a large automatic car wash facility near Montreal. The following table provides data concerning the company’s costs:

For example, electricity costs are $1,300 per month plus $0.06 per car washed. The company expects to wash 8,400 cars in August and to collect an average of $6.80 per car washed.

The actual operating results for August appear below.

Required:

Prepare a flexible budget performance report that shows the company’s revenue and spending variances and activity variances for August. (Indicate the effect of each variance by selecting "F" for favorable, "U" for unfavorable, and "None" for no effect (i.e., zero variance). Input all amounts as positive values.)

Lavage Rapide is a Canadian company that owns and operates a large automatic car wash facility near Montreal. The following table provides data concerning the company’s costs:

For example, electricity costs are $1,300 per month plus $0.06 per car washed. The company expects to wash 8,400 cars in August and to collect an average of $6.80 per car washed.

The actual operating results for August appear below.

Required:

Prepare a flexible budget performance report that shows the company’s revenue and spending variances and activity variances for August. (Indicate the effect of each variance by selecting "F" for favorable, "U" for unfavorable, and "None" for no effect (i.e., zero variance). Input all amounts as positive values.)

Movie Theater Attendance The data shown are the weekly admissions, in millions, of people attending movie theaters over three different time periods. At α = 0.05, is there a difference in the means for the weekly attendance for these time periods?

Use the traditional method of hypothesis testing unless otherwise specified.

a. State the hypotheses and identify the claim.

b. Find the critical value.

c. Compute the test value.

d. Make the decision.

e. Summarize the results.

H₀: μ₁ = μ₂ = μ₃. H₁: At least one mean is different from the others (claim); C.V. = 3.89; d.f.N. = 2; d.f.D. = 12; α = 0.05; F = 1.89; do not reject. There is not enough evidence to support the claim that at least one mean is different from the others.