a) (i) What is it about a mutant phenotype that classifies the mutation as “temperature-sensitive”?
(ii) How is this type of phenotype explained by protein behaviour?
b) Would the following types of mutations most likely have: severe effects, mild effects, or no effect on protein function? Briefly explain your answers. Note that there may be more than one correct answer, but you need only to give one sensible answer and explain your reasoning.
(i) A nonsense mutation occurring in sequences encoding amino acids near the carboxy terminus of the protein
(ii) A missense mutation affecting the active site of the protein
(iii) A frameshift mutation near the 5’ end of the open reading frame
In: Biology
Different measures of disease are useful to evaluate and assess public health programs and needs in different situations. For each of the following questions, state which measure would best support your goal. (1 point each) Measures of disease:
I = incidence rate
P = prevalence
R = sex ratio (counts)
- Show increase of new cases of car-train crashes at a railroad crossing without warning signal.
- Show existing cases of children with asthma due to exposure to secondhand cigarette smoke.
- Show endemic rates of leukemia in towns near industries along the Mississippi River
- Compare number of boys and girls who experience near-death from drowning in a city.
In: Nursing
The American Airlines Flight 965 near Cali, Colombia, while approaching the airport, the pilot intended to lock the autopilot onto the beacon, called Rozo, that would lead the plane to the airport. The pilot typed "R," and the computer system displayed six beacons beginning with "R." Normally, the closest beacon is at the top of the list. The pilot selected it without checking carefully. The beacon at the top of the list was "Romeo" and was more than 100 miles away, near Bogota. The plane turned more than 90 degrees and headed for Romeo. In the dark, it crashed into a mountain, killing 159 people.
Evaluating the incident, identify the reasons for failure of the system and what actions could prevent such incident to take place?
In: Finance
The first step in the forecasting game plan is to project sales and other operating activities. Sales numbers are determined by both a volume component and price component. Projecting prices depends on factors specific to the firm and its industry that might affect demand and price elasticity. For the following types of firms discuss whether it would be likely that the firm would be able to raise future prices:
a. A firm in a capital-intensive industry that is expected to operate near capacity for the near future.
b. A firm in an industry that is expected to experience numerous technological improvements.
c. A firm with products which are transitioning from the growth to maturity phase of the product life cycle.
d. A firm that has established a well-known brand name and image.
In: Accounting
The first step in the forecasting game plan is to project sales and other operating activities. Sales numbers are determined by both a volume component and price component. Projecting prices depends on factors specific to the firm and its industry that might affect demand and price elasticity. For the following types of firms, discuss whether it would be likely that the firm would be able to raise future prices:
|
a. |
A firm in a capital-intensive industry that is expected to operate near capacity for the near future. |
|
b. |
A firm in an industry that is expected to experience numerous technological improvements. |
|
c. |
A firm with products that are transitioning from the growth to maturity phase of the product life cycle. |
|
d. |
A firm that has established a well-known brand name and image. |
In: Finance
Consider the following gas-phase reaction: C6H6(g) 3 C2H2(g) Using data from Appendix C of your textbook calculate the temperature, To, at which this reaction will be at equilibrium under standard conditions (Go = 0) and choose whether >Go will increase, decrease, or not change with increasing temperature from the pulldown menu.
T = ____K, and G will _______
For each of the temperatures listed below calculate G for the reaction above, and select from the pulldown menu whether the reaction under standard conditions will be spontaneous, nonspontaneous, or near equilibrium ("near equilibrium" means that T is within 5 K of To).
(a) At T = 896 K G=
(b) At T = 1792 K G=
(c) At T = 2688 K G=
In: Chemistry
-How many degrees of angle does the Sun’s position change per day due to Earth’s rotation?
-How about degrees of angle per day due to Earth’s revolution around the Sun?
-What is the Celestial Equator? What is the Ecliptic? What is the Ecliptic Plane?
-Remember that a circle has 360 degrees [deg], one degree equals 60 arcminutes [min], and one arcminute equals 60 arcseconds [sec]. Show your calculations.
(a) What is the average angular size of a zodiac constellation on the sky? ________________________________________________________________
(b) 20.25 degrees = how many arcminutes? ____________________________________
(c) 35deg 25min 45sec = how many arcseconds? ________________________________
-The sky is divided into zones of motion. Describe the typical paths of stars moving:
- near the North Celestial Pole
- near the eastern horizon
- near the southern horizon
- What are latitude and longitude on Earth? What are right ascension (RA) and declination (DEC) on the sky?
- What is the angle of the NCP over the horizon at a latitude of 60 degrees? How about at the equator?
- Two important great circles on the celestial sphere that are important are the ecliptic and the celestial equator. How are they defined with respect to the celestial sphere?
- What is the angle between the ecliptic and celestial equator? Why is that important?
In: Physics
New Startup Restaurant
Could you please prepare:
-Pro forma balance sheet at the end of first year
-Pro forma Income statement for first year
-pro forma statement of cash flow for first year
with the informaton below
The capital needs of my start-up business for the first year:
Facility (building & land): $500,000
Appliances (freezers, stoves, etc.): $150,000
Furnishings (chairs, tables, décor, etc.): $75,000
Plates, silverware, and glasses: $20,000
Subtotal: $745,000
Working capital finances for first year
Salaries: $400,000
Utilities: $25,000
Groceries/Supplies: $50,000
Advertising: $15,000
Subtotal: $490,000
Adding up both subtotals, my restaurant will need a grand total of $1,235,000 to cover the first year’s business.
Please Describe how the figures in the pro forma financial statements were derived and why you think that they are accurate.
Please wrap up by preparing an explanation discussing how you arrived at the various figures.
Thank you, I appreciate
In: Accounting
A 115 kg seal at an amusement park slides from rest down a ramp into the pool below. The top of the ramp is 2.00 m higher than the surface of the water and the ramp is inclined at an angle of 26.5 ∘ above the horizontal.
Part A
Part complete
If the seal reaches the water with a speed of 4.55 m/s, what is the work done by kinetic friction?
Express your answer using three significant figures.
Part B
What is the coefficient of kinetic friction between the seal and the ramp?
In: Physics
The health of the bear population in Yellowstone National Park is monitored by
periodic measurements taken from anesthetized bears. In a sample of 100 bears, the mean weight was found to be 185 lbs. Assume that ơ (population standard deviation) is known to be 125 lbs, use a 0.03 significance level to test the claim that the population mean weight of bears is equal to 210 lbs.
(a) µ £ .210 (b) µ ³ .185 (c) µ = 185 (d) µ = 210
(A) Ho: µ ³ 210 H1: µ < 210 (b) Ho: µ = 210 H1: µ ≠ 210
(c) Ho: µ ≠ 210 H1: µ = 210 (d) Ho: µ £ 185 H1: µ > 185
(a) 2.00 (b) 0.0228 (c) -2.00 (d) .0456
(a) 0.0228 (b) 0.456 (c) -2.00 (d) 0.0456
show work
In: Statistics and Probability